Impact of tissue injury induced by diagnostic biopsies and surgery on cancer metastasis

Informacje na temat projektu

INJURMET

Identyfikator umowy o grant: 834974

DOI

10.3030/834974

Projekt został zamknięty

Data podpisania przez KE 23 Lipca 2019

Data rozpoczęcia 1 Sierpnia 2019

Data zakończenia 31 Lipca 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 499 985,00

Wkład UE

€ 2 499 985,00

Koordynowany przez

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (32)

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

Autorzy: Giannou AD, Kempski J, Shiri AM, Lücke J, Zhang T, Zhao L, Zazara DE, Cortesi F, Riecken K, Amezcua Vesely MC, Low JS, Xu H, Kaffe E, Garcia-Perez L, Agalioti T, Yamada Y, Jungraithmayr W, Zigmond E, Karstens KF, Steglich B, Wagner J, Konczalla L, Carambia A, Schulze K, von Felden J, May P, Briukhovetska D, Bedke T, Brockmann L, Starzonek S, Lange T, Koch C, Riethdorf S, Pelczar P, Böttcher M, S
Opublikowane w: Immunity, 2023, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2022.12.014

Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity

Autorzy: Claudia Koch, Andra Kuske, Simon A Joosse, Gökhan Yigit, George Sflomos, Sonja Thaler, Daniel J Smit, Stefan Werner, Kerstin Borgmann, Sebastian Gärtner, Parinaz Mossahebi Mohammadi, Laura Battista, Laure Cayrefourcq, Janine Altmüller, Gabriela Salinas‐Riester, Kaamini Raithatha, Arne Zibat, Yvonne Goy, Leonie Ott, Kai Bartkowiak, Tuan Zea Tan, Qing Zhou, Michael R Speicher, Volkmar Müller,
Opublikowane w: EMBO Molecular Medicine, Numer 12/9, 2020, ISSN 1757-4676
Wydawca: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201911908

Circulating tumor cells and extracellular vesicles as liquid biopsy markers in neuro-oncology: prospects and limitations.

Autorzy: Westphal M, Pantel K, Ricklefs FL, Maire C, Riethdorf S, Mohme M, Wikman H, Lamszus K
Opublikowane w: Neurooncol Adv., 2022, ISSN 2632-2498
Wydawca: EANO
DOI: 10.1093/noajnl/vdac015

Metastatic Breast Cancer Recurrence after Bone Fractures

Autorzy: Nadia Obi; Stefan Werner; Frank Thelen; Heiko Becher; Klaus Pantel
Opublikowane w: Cancers, Numer 5, 2022, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030601

Possible Role of Circulating Tumour Cells for Prediction of Salvage Lymph Node Dissection Outcome in Patients with Early Prostate Cancer Recurrence

Autorzy: Sophie Knipper, Sabine Riethdorf, Stefan Werner, Derya Tilki, Markus Graefen, Klaus Pantel, Tobias Maurer
Opublikowane w: Eur Urol Open Sci, Numer 34, 2021, Strona(/y) 55-58
Wydawca: Elsevier
DOI: 10.1016/j.euros.2021.09.017

Liquid biopsy: blood-based analyses of circulating cell-free DNA in xenografts.

Autorzy: Heidrich I, Pantel K
Opublikowane w: EMBO Mol Med, 2022, ISSN 1757-4684
Wydawca: EMBOpress
DOI: 10.15252/emmm.202216326

Clinical applications of circulating tumor cells in patients with solid tumors

Autorzy: Smit DJ, Schneegans S, Pantel K.
Opublikowane w: Clin Exp Metastasis, 2024, ISSN 0262-0898
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10585-024-10267-5

Detection of Hypomethylation in Long-ctDNA

Autorzy: Joosse SA, Pantel K
Opublikowane w: Clin Chem, 2022, ISSN 0009-9147
Wydawca: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvac108

Tumor-Associated Release of Prostatic Cells into the Blood after Transrectal Ultrasound-Guided Biopsy in Patients with Histologically Confirmed Prostate Cancer

Autorzy: Simon A Joosse, Burkhard Beyer, Christin Gasch, Paulina Nastały, Andra Kuske, Hendrik Isbarn, Ludwig J Horst, Claudia Hille, Tobias M Gorges, Laure Cayrefourcq, Catherine Alix-Panabières, Pierre Tennstedt, Sabine Riethdorf, Thorsten Schlomm, Klaus Pantel
Opublikowane w: Clinical Chemistry, Numer 66/1, 2019, Strona(/y) 161-168, ISSN 0009-9147
Wydawca: American Association for Clinical Chemistry, Inc.
DOI: 10.1373/clinchem.2019.310912

Detection and Characterization of Estrogen Receptor α Expression of Circulating Tumor Cells as a Prognostic Marker

Autorzy: Retno Ningsi; Maha Elazezy; Luisa Stegat; Elena Laakmann; Sven Peine; Sabine Riethdorf; Volkmar Müller; Klaus Pantel; Simon A. Joosse
Opublikowane w: Cancers, Numer 1, 2022, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14112621

Functional Characterization of Circulating Tumor Cells (CTCs) from Metastatic ER+/HER2- Breast Cancer Reveals Dependence on HER2 and FOXM1 for Endocrine Therapy Resistance and Tumor Cell Survival: Implications for Treatment of ER+/HER2- Breast Cancer.

Autorzy: Sven Roßwag; Cristina L. Cotarelo; Klaus Pantel; Sabine Riethdorf; Jonathan P. Sleeman; Jonathan P. Sleeman; Marcus Schmidt; Sonja Thaler
Opublikowane w: Cancers, Numer 4, 2021, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13081810

Multibiomarker panels in liquid biopsy for early detection of pancreatic cancer – a comprehensive review

Autorzy: Kim-Lea Reese, Klaus Pantel, Daniel J. Smit
Opublikowane w: Journal of Experimental & Clinical Cancer Research, Numer 43, 2024, ISSN 1756-9966
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/s13046-024-03166-w

Circulating Tumor Cells: From Basic to Translational Research

Autorzy: Cortés-Hernández LE, Eslami-S Z, Pantel K, Alix-Panabières C
Opublikowane w: Clin Chem, 2024, ISSN 0009-9147
Wydawca: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvad142

Circulating tumor cells as liquid biopsy markers in cancer patients

Autorzy: Daniel J. Smit, Klaus Pantel
Opublikowane w: Molecular Aspects of Medicine, Numer 96, 2025, Strona(/y) 101258, ISSN 0098-2997
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2024.101258

Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond

Autorzy: Laura Keller, Yassine Belloum, Harriet Wikman, Klaus Pantel
Opublikowane w: British Journal of Cancer, Numer 124/2, 2021, Strona(/y) 345-358, ISSN 0007-0920
Wydawca: Nature Publishing Group
DOI: 10.1038/s41416-020-01047-5

Expression Patterns and Corepressor Function of Retinoic Acid-induced 2 in Prostate Cancer

Autorzy: Besler K, Węglarz A, Keller L, von Amsberg G, Bednarz-Knoll N, Offermann A, Stoupiec S, Eltze E, Semjonow A, Boettcher L, Schneegans S, Perner S, Hauch S, Todenhöfer T, Peine S, Pantel K, Wikman H, Werner S
Opublikowane w: Clin Chem, 2022, ISSN 0009-9147
Wydawca: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvac073

PSMA-heterogeneity in metastatic castration-resistant prostate cancer: Circulating tumor cells, metastatic tumor burden, and response to targeted radioligand therapy

Autorzy: Derlin T, Riethdorf S, Schumacher U, Lafos M, Peine S, Coith C, Ross TL, Pantel K, Bengel FM
Opublikowane w: Prostate, 2023, ISSN 0270-4137
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/pros.24549

Crucial roles of circulating tumor cells in the metastatic cascade and tumor immune escape: biology and clinical translation

Autorzy: Pantel K, Alix-Panabières C
Opublikowane w: Immunother Cancer, 2022, ISSN 2051-1426
Wydawca: BMJ
DOI: 10.1136/jitc-2022-005615

Circulating Cellular Communication Network Factor 1 Protein as a Sensitive Liquid Biopsy Marker for Early Detection of Breast Cancer

Autorzy: Kai Bartkowiak, Isabel Heidrich, Marcel Kwiatkowski, Maggie Banys-Paluchowski, Antje Andreas, Marcus Wurlitzer, Maria Geffken, Hannah Voß, Tanja Zeller, Stefan Blankenberg, Sven Peine, Simon A Joosse, Volkmar Müller, Hartmut Schlüter, Leticia Oliveira-Ferrer, Klaus Pantel
Opublikowane w: Clin Chem, Numer 68/2, 2021, Strona(/y) 344–353, ISSN 1530-8561
Wydawca: Oxfor Academic
DOI: 10.1093/clinchem/hvab153

Discovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients

Autorzy: Kai Bartkowiak, Parinaz Mossahebi Mohammadi, Paula Nissen, Stefan Werner, David Agorku, Antje Andreas, Maria Geffken, Sven Peine, Karl Verpoort, Thomas M. Deutsch, Laura L. Michel, Andreas Schneeweiss, Verena Thewes, Andreas Trumpp, Olaf Hardt, Volkmar Müller, Sabine Riethdorf, Hartmut Schlüter, Klaus Pantel
Opublikowane w: Scientific Reports, Numer 15, 2025, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-025-87122-4

Liquid biopsies: Potential and challenges

Autorzy: Isabel Heidrich, Lucija Ačkar, Parinaz Mossahebi Mohammadi, Klaus Pantel
Opublikowane w: International Journal of Cancer, Numer 148/3, 2021, Strona(/y) 528-545, ISSN 0020-7136
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/ijc.33217

Cysteine-Rich Angiogenic Inducer 61: Pro-Survival Function and Role as a Biomarker for Disseminating Breast Cancer Cells

Autorzy: Kai Bartkowiak, Isabel Heidrich, Marcel Kwiatkowski, Tobias M. Gorges, Antje Andreas, Maria Geffken, Karl Verpoort, Volkmar Müller, Hartmut Schlüter, Klaus Pantel
Opublikowane w: Cancers, Numer 13/3, 2021, Strona(/y) 563, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030563

Circulating tumour cells for early detection of clinically relevant cancer

Autorzy: Lawrence R, Watters M, Davies CR, Pantel K, Lu YJ
Opublikowane w: Nat Rev Clin Oncol, 2023, ISSN 1759-4774
Wydawca: Nature Publishing Group
DOI: 10.1038/s41571-023-00781-y

Minimal residual disease as a target for liquid biopsy in patients with solid tumours

Autorzy: Klaus Pantel, Catherine Alix-Panabières
Opublikowane w: Nature Reviews Clinical Oncology, Numer 22, 2024, Strona(/y) 65-77, ISSN 1759-4774
Wydawca: Nature Publishing Group
DOI: 10.1038/s41571-024-00967-y

Pre-Analytical and Analytical Variables of Label-Independent Enrichment and Automated Detection of Circulating Tumor Cells in Cancer Patients

Autorzy: Claudia Koch, Simon A. Joosse, Svenja Schneegans, Okka J. W. Wilken, Melanie Janning, Desiree Loreth, Volkmar Müller, Katharina Prieske, Malgorzata Banys-Paluchowski, Ludwig J. Horst, Sonja Loges, Sven Peine, Harriet Wikman, Tobias M. Gorges, Klaus Pantel
Opublikowane w: Cancers, Numer 12/2, 2020, Strona(/y) 442, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12020442

Neoadjuvant Chemotherapy of Patients with Early Breast Cancer Is Associated with Increased Detection of Disseminated Tumor Cells in the Bone Marrow.

Autorzy: Léa Volmer; André Koch; Sabine Matovina; Dominik Dannehl; Martin Weiss; Ganna Welker; Markus Hahn; Tobias Engler; Markus Wallwiener; Christina Barbara Walter; Ernst Oberlechner; Sara Yvonne Brucker; Klaus Pantel; Andreas Hartkopf
Opublikowane w: Cancers, Numer 3, 2022, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030635

Functional analysis of circulating tumour cells: the KEY to understand thebiology of the metastatic cascade

Autorzy: Eslami-S Z, Cortés-Hernández LE, Thomas F, Pantel K, Alix-Panabières C.
Opublikowane w: Br J Cancer, 2022, ISSN 0007-0920
Wydawca: Nature Publishing Group
DOI: 10.1038/s41416-022-01819-1

Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels

Autorzy: Leong SP, Naxerova K, Keller L, Pantel K, Witte M.
Opublikowane w: Clin Exp Metastasis, 2022, ISSN 0262-0898
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10585-021-10120-z

Molecular profiling of an osseous metastasis in glioblastoma during checkpoint inhibition: potential mechanisms of immune escape

Autorzy: Malte Mohme, Cecile L. Maire, Simon Schliffke, Simon A. Joosse, Malik Alawi, Jakob Matschke, Ulrich Schüller, Judith Dierlamm, Tobias Martens, Klaus Pantel, Sabine Riethdorf, Katrin Lamszus, Manfred Westphal
Opublikowane w: Acta Neuropathologica Communications, Numer 8/1, 2020, ISSN 2051-5960
Wydawca: BioMed Central
DOI: 10.1186/s40478-020-00906-9

Mutation analysis in individual circulating tumor cells depicts intratumor heterogeneity in melanoma

Autorzy: Mark Sementsov, Leonie Ott, Julian Kött, Alexander Sartori, Amelie Lusque, Sarah Degenhardt, Bertille Segier, Isabel Heidrich, Beate Volkmer, Rüdiger Greinert, Peter Mohr, Ronald Simon, Julia-Christina Stadler, Darryl Irwin, Claudia Koch, Antje Andreas, Benjamin Deitert, Verena Thewes, Andreas Trumpp, Andreas Schneeweiss, Yassine Belloum, Sven Peine, Harriett Wikman, Sabine Riethdorf, Stefan W S
Opublikowane w: EMBO Molecular Medicine, Numer 16, 2024, Strona(/y) 1560-1578, ISSN 1757-4684
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s44321-024-00082-6

Comparative analysis of circulating tumor cells in prostatic plexus and peripheral blood of patients undergoing prostatectomy

Autorzy: Gresa Emurlai, Randi M. Pose, Nikhil Kalra, Cornelia Coith, Sandra Lenz, Pierre Tennstedt, Markus Graefen, Stefan Werner, Sabine Riethdorf, Derya Tilki, Simon A. Joosse, Klaus Pantel
Opublikowane w: Journal of Experimental & Clinical Cancer Research, Numer 44, 2025, ISSN 1756-9966
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/s13046-025-03397-5

MicroRNAs from Liquid Biopsy Derived Extracellular Vesicles: Recent Advances in Detection and Characterization Methods

Autorzy: Rares Drula, Leonie Florence Ott, Ioana Berindan-Neagoe, Klaus Pantel, George A. Calin
Opublikowane w: Cancers, Numer 12/8, 2020, Strona(/y) 2009, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082009

Prawa własności intelektualnej

Patent (2)

METHOD OF DETECTING CANCER OR CANCER CELLS

Numer wniosku/publikacji: 17 157020
Data: 2017-02-20
Wnioskodawca/wnioskodawcy: UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

METHOD OF DETECTING CANCER OR CANCER CELLS

Numer wniosku/publikacji: 20 18054052
Data: 2018-02-19
Wnioskodawca/wnioskodawcy: UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF