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The Role of Antibodies (Ig) and the Respiratory Epithelium in the Prevention of Invasive Meningococcal Infections in Different Age Groups

Project description

Dissecting the invasiveness of meningococcal infections

Recent years have witnessed a re-emergence of the meningococcal serogroup W type-11 strain which demonstrates increased invasiveness. To address this medical challenge, the EU-funded EpIg Men project will investigate the virulence factors responsible for the invasiveness of this strain and whether antibodies can still clear the pathogen. In particular, researchers will study the mechanisms underlying the interaction of meningococcal bacteria with epithelial cells and evaluate the ability of antibodies from different age groups to protect against infection. Results will help formulate novel public protection measures and potentially identify novel targets for therapies as well as vaccine design.

Coordinator

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Net EU contribution
€ 187 572,48
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Netherlands

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Region
West-Nederland Utrecht Utrecht
Activity type
Research Organisations
Other funding
€ 187 572,48