Role of the recycling endosomes in tumour interaction with the stroma
Endocytosis of cell surface receptors regulates signalling during differentiation, proliferation, and migration of cells. Invasive cancer cells accumulate recycling endosomes at protrusions, delivering receptors for extracellular matrix, regulating tumour cells interactions with microenvironment, and coordinating actin polymerisation through Rho family GTPases. The Rab11 GTPase family is implicated in determining the aggressiveness of high-grade serous ovarian carcinoma (HGSOC). The EU-funded EndoPos project aims to determine recycling endosomes positioning within HGSOC cells invading the extracellular matrix. A combination of innovative approaches will help to elucidate how localised endocytic trafficking controls tumour-stroma interactions and contributes to HGSOC progression.