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Endosome positioning in tumour-stroma interactions

Project description

Role of the recycling endosomes in tumour interaction with the stroma

Endocytosis of cell surface receptors regulates signalling during differentiation, proliferation, and migration of cells. Invasive cancer cells accumulate recycling endosomes at protrusions, delivering receptors for extracellular matrix, regulating tumour cells interactions with microenvironment, and coordinating actin polymerisation through Rho family GTPases. The Rab11 GTPase family is implicated in determining the aggressiveness of high-grade serous ovarian carcinoma (HGSOC). The EU-funded EndoPos project aims to determine recycling endosomes positioning within HGSOC cells invading the extracellular matrix. A combination of innovative approaches will help to elucidate how localised endocytic trafficking controls tumour-stroma interactions and contributes to HGSOC progression.

Coordinator

THE UNIVERSITY OF MANCHESTER
Net EU contribution
€ 224 933,76
Address
Oxford Road
M13 9PL Manchester
United Kingdom

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Region
North West (England) Greater Manchester Manchester
Activity type
Higher or Secondary Education Establishments
Other funding
€ 224 933,76