Electrical Discharge Machining for enhanced osseointegration and antibacterial capabilities of β-phase Titanium Implant

Description du projet

Des implants osseux aux caractéristiques améliorées

Les implants orthopédiques sont utilisés pour remplacer un os ou une articulation, ou pour soutenir la partie endommagée d’un os. Dans l’idéal, ces implants doivent être performants tout au long de leur vie, ce qui se traduit par des implants présentant une ostéo‑intégration fonctionnelle et des caractéristiques antibactériennes. À cette fin, le projet EDiMplant, financé par l’UE, propose de développer une technique de modification de la surface des implants orthopédiques. Les chercheurs souhaitent fabriquer des couches superficielles combinant des caractéristiques ostéogéniques et antibactériennes améliorées. Les résultats du projet contribueront à réduire l’incidence des défaillances des implants orthopédiques et à améliorer la qualité de vie des personnes atteintes, dont le nombre augmente en raison du vieillissement de la population.

Objectif

Recently, the demand for orthopaedic implants and devices has undertaken rapid growth due to the aging population and its global market is anticipated to reach $66.2B in 2023. To ensure the long-term survival of orthopaedic implants, it is urgent to tailor a multifunctional surface which would simultaneously have enhanced osteogenic and antibacterial properties. Therefore, the aim is to develop a competent surface modification technique which will promote improved osseointegration whilst retaining antimicrobial activity, thus ensuring the life-long performance of implants. A novel surface modification approach will be demonstrated using the specially designed tool electrodes in powder mixed electric discharge machining process for fabrication of modified surface layers exhibiting anti-bacterial and osteogenic characteristics. Exploiting world class facilities at University of Sheffield and a unique multidisciplinary framework; EDiMplant will reach the aim and strengthen the pillars of Horizon 2020.
Supervisor(s) with world-leading experience, Dr Gwendolen Reilly, Dr Frederik Claeyssens, Dr Russell Goodall, and Dr Joanna Shepherd, will provide expert training and support to the Fellow in the essential skills inmaterial science, tissue engineering and infection biology, while, Dr Deepak Unune, leading Indian researcher, will bring expertise and novel application of electric discharge machining in surface modifications of implants to the host(s). The high-quality two-way transfer of knowledge required for this project will ensure the research goals of the highest quality are achieved, whilst also presenting a great opportunity to accelerate the academic career of the Fellow. Success would also lead to significant economic and societal impacts for the EU and worldwide, by aiding in the reduced incidence of orthopaedic implant failures.