Whispering Gallery Modes (WGM) for label free bioanalytics

Projektinformationen

WhisperSense

ID Finanzhilfevereinbarung: 837028

DOI

10.3030/837028

Projekt abgeschlossen

EK-Unterschriftsdatum 20 Dezember 2018

Startdatum 1 Januar 2019

Enddatum 30 Juni 2019

Finanziert unter

• INDUSTRIAL LEADERSHIP - Innovation In SMEs

Gesamtkosten

€ 71 429,00

EU-Beitrag

€ 50 000,00

Koordiniert durch

Surflay Nanotec GmbH
Germany

Periodic Reporting for period 1 - WhisperSense (Whispering Gallery Modes (WGM) for label free bioanalytics)

Berichtszeitraum: 2019-01-01 bis 2019-06-30

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

“According to the latest industry research, about 90 percent of drugs that reach clinical stage development never make it to FDA approval and commercialisation; the same applies to diagnostic markers.” One crucial point is that usually, in the early stage of drug development and biomarker identification, reliable data can only be obtained in artificial, extremely well-defined environments (purified binding partners, no complex biological matrices). However, the data obtained in this way did not take the native environment into account delivering false positive or false negative results. For that reason, the development and identification of new drugs and biomarkers takes a long time, and patients cannot be helped. Thanks to an innovative, proprietary particle-based approach using the physical effect of Whispering Gallery Modes (WGM), Surflay Nanotec GmbH is able to overcome most of these limitations. Our WGM system “WhisperSense” will allow a direct, real-time and spatially well-resolved interaction and concentration determination in cell cultures. Furthermore, direct full kinetic characterisation in the natural environment will be possible for cell culture microfluidic chips (organ-on-a-chip).

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

In the course of the SME I action, Surflay Nanotec GmbH improves the business plan and gets further information of the performance by a benchmark study. It could be demonstrated that kinetic measurements of antigen and antibody interactions perform by the WGM-instrument as good as by the SPR-measurement (Biacore T200 instrument).
The SME I tool made it possible to conduct a survey among manufacturers and users of organ-on-a-chip systems to find out what technology we would be offering in the future. It turned out that there is a massive lack of online analytics for cell culture and organ-on-a-chip experiments.
Another important result of the SME I tool was the detailed further development of the financial plan for the next 5 years. All the information and results obtained led to the finalisation of the existing business plan.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

The WGM measurement method based on fluorescent microparticles will greatly improve the information depth of cell culture experiments and organ-on-a-chip systems.
In the future, it will be possible to detect the expression level of individual proteins and track it online.
In particular, this will accelerate and improve the identification, testing and development of new drugs for the pharmaceutical industry.

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