Synapses between Leukaemia and its Neighbouring Cells

Project description

The bone marrow niche in health and disease

Haematopoietic stem cells reside in a specific microenvironment of the bone marrow known as a niche. The niche encompasses different types of cells, the extracellular matrix, and paracrine factors that collectively support the undifferentiated state and self-renewal capacity of stem cells. The EU-funded SyLeNCe project is interested in dissecting the interaction between niche components during homeostasis and disease. Emphasis will be given to the detailed characterisation of cell relationships during malignant transformation in leukaemia as well as disease development and progression. The SyLeNCe work will offer a more holistic view of the stem cell niche and may unveil new candidates for the treatment of leukaemia.

Fields of science

• medical and health sciences › medical biotechnology › cells technologies › stem cells
• natural sciences › biological sciences › ecology › ecosystems
• natural sciences › biological sciences › genetics › RNA
• medical and health sciences › clinical medicine › oncology › leukemia
• medical and health sciences › basic medicine › physiology › homeostasis

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

See other projects for this call

Funding Scheme

MSCA-IF-EF-RI - RI – Reintegration panel

Coordinator

FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA

Net EU contribution

€ 160 932,48

Address

Avenida De Pio Xii 55
31008 Pamplona
Spain

Region

Noreste › Comunidad Foral de Navarra › Navarra

Activity type

Research Organisations

Links

Non-EU contribution

€ 0,00