The bone marrow niche in health and disease
Haematopoietic stem cells reside in a specific microenvironment of the bone marrow known as a niche. The niche encompasses different types of cells, the extracellular matrix, and paracrine factors that collectively support the undifferentiated state and self-renewal capacity of stem cells. The EU-funded SyLeNCe project is interested in dissecting the interaction between niche components during homeostasis and disease. Emphasis will be given to the detailed characterisation of cell relationships during malignant transformation in leukaemia as well as disease development and progression. The SyLeNCe work will offer a more holistic view of the stem cell niche and may unveil new candidates for the treatment of leukaemia.