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Synapses between Leukaemia and its Neighbouring Cells

Project description

The bone marrow niche in health and disease

Haematopoietic stem cells reside in a specific microenvironment of the bone marrow known as a niche. The niche encompasses different types of cells, the extracellular matrix, and paracrine factors that collectively support the undifferentiated state and self-renewal capacity of stem cells. The EU-funded SyLeNCe project is interested in dissecting the interaction between niche components during homeostasis and disease. Emphasis will be given to the detailed characterisation of cell relationships during malignant transformation in leukaemia as well as disease development and progression. The SyLeNCe work will offer a more holistic view of the stem cell niche and may unveil new candidates for the treatment of leukaemia.

Coordinator

FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Net EU contribution
€ 160 932,48
Address
Avenida De Pio Xii 55
31008 Pamplona
Spain

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Region
Noreste Comunidad Foral de Navarra Navarra
Activity type
Research Organisations
Non-EU contribution
€ 0,00