Descrizione del progetto
Vescicole sensibili artificiali ispirate alla natura per applicazioni nanotecnologiche
Le cellule sono fabbriche complesse che producono, trasportano ed esportano o importano «prodotti» in cascate di elaborazione del segnale e comunicazione virtualmente illimitate. Data la compartimentazione tramite membrane sia all’interno che tra le cellule, molti di questi percorsi si basano anche sul movimento di sostanze attraverso le membrane in vari modi, comprendenti l’apertura di pori, il trasporto attivo contro gradienti di concentrazione tramite macchine transmembrana in miniatura o anche fusione di membrane di vescicole con altre membrane per espellere o iniettare il carico vescicolare verso l’altro lato. Il progetto CoVes, finanziato dall’UE, sta sviluppando una piattaforma sperimentale per studiare tali processi, consentendo la creazione di vescicole in grado di memorizzare e trasferire informazioni utilizzando stimoli e portando a una nanotecnologia di ispirazione biologica.
Obiettivo
Networks constituted from single components able to communicate with each other in a controlled manner are at the basis of every phenomenon occurring in the world around us. Understanding and controlling information transmission processes represents one of the greatest challenges for modern scientists. I propose to develop an understanding of the working principles of complex information processing networks by using an artificial system that resembles Nature’s cell-based communication systems. Inspired by the cascade processes occurring in Nature such as the second messenger system and extracellular messenger release, “CoVes” will be based on responsive Vesicles able to Communicate in a specific and targeted manner due to different input signals. Vesicles will be equipped with a series of synthetic transducers that respond to orthogonal external chemical stimuli. Transmembrane signalling will be coupled with internal chemical messenger release leading to communication between vesicles in an information network. The working principles of the novel multi-component ensembles will be investigated leading to systems capable of transmitting information under different diffusion conditions and paving the way for novel communication mechanisms. The accurate and reliable prediction of communication processes will lead to vesicle ensembles able to store and transfer information using orthogonal stimuli which will be crucial for the development of bio-inspired nanotechnology, such as interfaces for communication with cellular systems. The accomplishments achieved through CoVes will make chemistry not only the science of matter transformation, but also the science of information storage, elaboration and transfer.
Campo scientifico
Parole chiave
Programma(i)
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Meccanismo di finanziamento
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinatore
CB2 1TN Cambridge
Regno Unito