Treatment for oncogene addiction could be on the horizon
Cancer is the second leading cause of death globally and incidence and mortality are increasing. Within the last decade, scientists have discovered what may be the target for a silver bullet in many cases of cancer. While most cancers are characterised by multiple oncogenic mutations, a growing body of evidence demonstrates that many cancers are sensitive to inhibition of a single one of these. The term 'oncogene addiction' was coined to express a cancer's dependency on this single carcinogenic protein or pathway to maintain malignancy. The EU-funded Genetic Vaccine project is exploiting advanced technology to induce targeted mutations in select oncogenes. Effectiveness will be tested in an animal model of cancer.
Field of science
- /natural sciences/biological sciences/genetics and heredity/genome
- /natural sciences/biological sciences/genetics and heredity/mutation
- /medical and health sciences/clinical medicine/cancer
Call for proposal
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