Project description DEENESFRITPL Multistate modeling to predict risk markers for AF Atrial fibrillation (AF) is a severe medical condition often associated with increased mortality risk. The most common available diagnostical tool is Electrocardiogram (ECG). Numerous P wave indices (PWI) are associated with increased risk for adverse cardiovascular outcomes and mortality. The non-invasive signal-averaged electrocardiogram (SAECG) is more reliable for the detection of P wave prolongation as a risk marker for AF. However, available data analysing this issue are limited. The EU-funded SAECG project will perform P wave SAECGs in Framingham Heart Study (Boston, US) and LIFE Health Care Study (Leipzig, Germany) to investigate their role in AF incidence. The project will use multistate modeling phenomapping of AF to predict the corresponding lifetime risk. Show the project objective Hide the project objective Objective Atrial fibrillation (AF) may be categorized as an epidemic disease associated with an increased risk for heart failure, thromboembolism, dementia and mortality. The underlying mechanisms behind AF describe multiple pathological states leading to various remodeling processes. One of the easiest available diagnostical tools is an electrocardiogram (ECG). Numerous P wave indices have been identified, demonstrating associations with increased risk for adverse cardiovascular outcomes and mortality. Prolonged signal-averaged P wave duration (SAPWD) measured from the non-invasive signal averaged electrocardiogram (SAECG) using a vector composite of filtered orthogonal leads accurately measures cardiac activation times. In comparison with analysis of a standard 12-lead ECG, the SAECG is superior in detection of P wave prolongation as a risk marker for AF. However, there are only limited data analyzing this issue.Current project is aimed to perform P wave SAECGs in Framingham Heart Study (Boston, US) and LIFE Health Care Study (Leipzig, Germany) and to investigate their role in AF incidence. Furthermore, estimation of corresponding lifetime risk will be performed using multistate modeling phenomapping of AF, e.g. classification of AF patients based on a broad range of data (clinical, laboratory, ECG, echocardiography, biomarkers) predicting adverse clinical outcomes.The current project represents an innovative and authentic multidisciplinary research in AF and includes different future perspectives. It paves the way for fruitful international cooperation with Framingham cohort - the one the most renowned epidemiological studies, intensive exchange of experience and researcher mobility as well as academical and practical implementation of cardiovascular epidemiology and prevention at European institution. Fields of science social sciencessociologydemographymortalityengineering and technologymaterials engineeringcompositesmedical and health scienceshealth sciencespublic healthepidemiologymedical and health sciencesbasic medicineneurologydementiamedical and health sciencesclinical medicinecardiology Keywords atrial fibrillation electrocardiography (ECG) PR interval P wave indices risk stratification endophenotype epidemiology prevention biomarkers Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2018 - Individual Fellowships Call for proposal H2020-MSCA-IF-2018 See other projects for this call Funding Scheme MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinator UNIVERSITAET LEIPZIG Net EU contribution € 264 669,12 Address Ritterstrasse 26 04109 Leipzig Germany See on map Region Sachsen Leipzig Leipzig Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. THE TRUSTEES OF BOSTON UNIVERSITY United States Net EU contribution € 0,00 Address Commonwealth avenue 881 02215 Boston ma See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 177 265,92
