New biology of oncogenic PI 3-kinase

Projektinformationen

Oncogenic PI3-kinase

ID Finanzhilfevereinbarung: 838559

DOI

10.3030/838559

Projekt abgeschlossen

EK-Unterschriftsdatum 19 März 2019

Startdatum 1 Mai 2019

Enddatum 30 April 2021

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten

€ 212 933,76

EU-Beitrag

€ 212 933,76

Koordiniert durch

UNIVERSITY COLLEGE LONDON
United Kingdom

Periodic Reporting for period 1 - Oncogenic PI3-kinase (New biology of oncogenic PI 3-kinase)

Berichtszeitraum: 2019-05-01 bis 2021-04-30

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

This project studied PI 3-kinases (PI3Ks in short) that regulate fundamental processes in cells. Inhibitors against PI3K family members are now approved for the treatment of leukaemia and breast cancer. We focused on a PI3K family member which has been implicated in disease, including in cancer. Despite extensive research, key elements of PI3K biology are poorly understood, in part because we believe PI3K function has not been investigated in the appropriate conditions and models.
The primary cilium is a much-overlooked structure in a cell. This is a small antenna-like structure that projects out of each cell to sense the environment and is important for development and normal adult cell function. Here we have studied a new function for PI3K in controlling the primary cilium biology and identified novel signalling downstream of PI3K signalling.
We believe our findings have the potential to uncover insights into long-standing questions the in cilia biology field and help to understand how increased activity of PI3K contributes to disease. Understanding the mechanistic basis of disease informs and is essential for the process of drug development.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

We have established multiple techniques in the laboratory to increase and reduce PI3K activity in mice and cells. We have characterised the effects of increased PI3K activity in the developing mouse embryo. Furthermore, we have performed a comprehensive characterisation of the effects of altered PI3K activity on cilia biology in cells using both targeted and unbiased approaches.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

This project has identified a new role for PI3K in regulation of primary cilia biology. Primary cilia dysfunction is an important cause of human disease. Understanding how PI3K controls primary cilia will provide critical insight into diseases caused by both mutations in PI3K and abnormal cilia function and may inform future drug development efforts.

cilia phosphoinositides