Neural regulation of the immune system in the Gut

Project description

Towards a better understanding of the complex brain–gut connection

Some neuronal and immune cells in the intestine share anatomical features and influence each other's function, forming neuronal–immune cell units. However, whether brain-derived signals might control enteric immune functions and intestinal homeostasis has not been adequately studied. Curiously, the neurological dysfunction induced by stroke is associated with intestinal problems, including infections, inflammation and colorectal cancer. The promising preliminary data has demonstrated that stroke disrupts intestinal lymphocyte homeostasis, promoting their release from the gut to other organs. The EU-funded Neu-i-Gut project will investigate how the central nervous system affects intestinal immune homeostasis and whether brain-derived signals induce gastrointestinal disease. To that end, researchers will employ stroke and gastrointestinal disease models, together with genetic technology.

Fields of science

• natural sciences › biological sciences › neurobiology
• medical and health sciences › basic medicine › immunology
• medical and health sciences › basic medicine › neurology › stroke
• medical and health sciences › basic medicine › physiology › homeostasis
• medical and health sciences › clinical medicine › gastroenterology

Programme(s)

• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018
See other projects for this call

Funding Scheme

MSCA-IF-EF-RI - RI – Reintegration panel

Coordinator

FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD

Address

Avenida Brasilia, Centro De Investigacao Da Fundacao Champalimaud
1400-038 Lisboa
Portugal

Activity type

Research Organisations

Links

EU contribution

€ 159 815,04