Role of tau strain diversity in the phenotypes of Alzheimer’s disease
Dementia is a global challenge in our ageing world. Alzheimer’s disease (AD) is responsible for most dementia cases, yet no treatment is available. The EU-funded DIVE into AD project is searching for the determinants of AD clinical phenotypes via the analysis of pathological variants of the tau protein. It has been confirmed that tau deposition in the brain correlates with the hallmarks of AD neurodegeneration. Tau protein behaves like a prion and can spread from one neuron to another, and discrete tau strains generate distinct aggregates morphology and patterns of neuronal vulnerability. Therefore, the project's objective is to develop the technologies to identify tau strain fingerprints in different AD phenotypes.
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