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Study of tau strains to understand the phenotypic diversity of Alzheimer’s disease: A step toward personalized therapies

Project description

Role of tau strain diversity in the phenotypes of Alzheimer’s disease

Dementia is a global challenge in our ageing world. Alzheimer’s disease (AD) is responsible for most dementia cases, yet no treatment is available. The EU-funded DIVE into AD project is searching for the determinants of AD clinical phenotypes via the analysis of pathological variants of the tau protein. It has been confirmed that tau deposition in the brain correlates with the hallmarks of AD neurodegeneration. Tau protein behaves like a prion and can spread from one neuron to another, and discrete tau strains generate distinct aggregates morphology and patterns of neuronal vulnerability. Therefore, the project's objective is to develop the technologies to identify tau strain fingerprints in different AD phenotypes.

Call for proposal

H2020-MSCA-IF-2018
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Coordinator

UNIVERSITE DE GENEVE
Address
Rue Du General Dufour 24
1211 Geneve
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 190 207,68

Partners (1)

THE GENERAL HOSPITAL CORPORATION
United States
Address
Fruit Street 55
02114 Boston Ma
Activity type
Other