Study of tau strains to understand the phenotypic diversity of Alzheimer’s disease: A step toward personalized therapies

Project description

Role of tau strain diversity in the phenotypes of Alzheimer’s disease

Dementia is a global challenge in our ageing world. Alzheimer’s disease (AD) is responsible for most dementia cases, yet no treatment is available. The EU-funded DIVE into AD project is searching for the determinants of AD clinical phenotypes via the analysis of pathological variants of the tau protein. It has been confirmed that tau deposition in the brain correlates with the hallmarks of AD neurodegeneration. Tau protein behaves like a prion and can spread from one neuron to another, and discrete tau strains generate distinct aggregates morphology and patterns of neuronal vulnerability. Therefore, the project's objective is to develop the technologies to identify tau strain fingerprints in different AD phenotypes.

Fields of science

• medical and health sciences › basic medicine › neurology › alzheimer

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018
See other projects for this call

Funding Scheme

MSCA-IF-GF - Global Fellowships

Coordinator

UNIVERSITE DE GENEVE

Address

Rue Du General Dufour 24
1211 Geneve
Switzerland

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 190 207,68

Partners (1)

THE GENERAL HOSPITAL CORPORATION

United States

Address

Fruit Street 55
02114 Boston Ma

Activity type

Other