Decrypting Mycobacterium cytochrome P450 (CYP) physiological functions by testing hypotheses emitted form large-scale comparative genomics analysis

Project description

Novel molecular targets against Mycobacteria

Antimicrobial resistance is increasing in prevalence affecting various bacteria, including Mycobacterium tuberculosis. Profoundly, this necessitates the development of novel effective drugs. The project deCrYPtion, funded by the EU, proposes to target the cytochrome P450 (CYP) family of proteins as a treatment strategy. The main goal is to provide physiological information on a number of CYPs that have yet to be functionally characterised. Scientists will analyse the CYPs encoded by Mycobacterium species and link their function to specific biological pathways. deCrYPtion results will lead to the identification of novel drug targets against the Mycobacterium genus.

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• medical and health sciences › clinical medicine › pneumology › tuberculosis
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › antibiotics
• agricultural sciences › animal and dairy science › domestic animals › animal husbandry
• medical and health sciences › basic medicine › pharmacology and pharmacy › drug resistance › antibiotic resistance

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

See other projects for this call

Funding Scheme

MSCA-IF-EF-RI - RI – Reintegration panel

Coordinator

SWANSEA UNIVERSITY

Net EU contribution

€ 212 933,76

Address

Singleton Park
SA2 8PP Swansea
United Kingdom

Region

Wales › West Wales and The Valleys › Swansea

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 212 933,76