Cooperative Lewis base / Metal-Catalyzed Enantioselective Annulations

Información del proyecto

COOPCAT

Identificador del acuerdo de subvención: 839739

DOI

10.3030/839739

Proyecto cerrado

Fecha de la firma de la CE 10 Abril 2019

Fecha de inicio 1 Junio 2019

Fecha de finalización 31 Mayo 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 224 933,76

Aportación de la UE

€ 224 933,76

Coordinado por

UNIVERSITY OF BRISTOL
United Kingdom

Periodic Reporting for period 1 - COOPCAT (Cooperative Lewis base / Metal-Catalyzed Enantioselective Annulations)

Período documentado: 2019-06-01 hasta 2021-05-31

Resumen del contexto y de los objetivos generales del proyecto

Five to seven-membered heterocycles are of immense use biologically and industrially. Heterocycles are present in all types of organic compounds of interest in electronics, optics, biology, pharmacology, material sciences, etc. Five to seven-membered heterocycles impart an important function in medicinal chemistry and serve as key templates for the development of many therapeutic agents. There are many common therapeutic uses of synthetic heterocycles such as antibacterial, trypanocidal, antimycobacterial, genotoxic, anti-HIV activity, herbicidal, anti-inflammatory, analgesic, antileishmanial agents, muscle relaxants, anticonvulsant, anticancer, antifungal antimalarial, antitubercular, hypnotics, anthelmintic, antidepressant, antitumoral, and insecticidal agents. The exploration of new bioactive heterocyclic analogs continues to be an area of intensive research in pharmaceutical chemistry. The project set out to devise new efficient ways to make such molecules.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

The initial approach to the target molecules turned out to be unsuccessful, but an alternative method based on organolithium photochemistry did deliver useful products, and two publications are in the process of being edited ready for dissemination.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

The alternative methods developed have shown that mild photochemical methods using LED irradiation can push forward the state of the art in synthetic photochemistry - this was not part of the original proposal, that was discovered while attempting to solve the problems that were encountered during the project. This aspect of the work has a significant future potential impact in synthesis as it will allow low energy bulbs to be used for heterocyclic synthesis in routes that employ reactive intermediates as chromophores.

Further project proposals will be developed in which such a reaction is employed as a key step.

photochemistry using LED