Cooperative Lewis base / Metal-Catalyzed Enantioselective Annulations

Projektinformationen

COOPCAT

ID Finanzhilfevereinbarung: 839739

DOI

10.3030/839739

Projekt abgeschlossen

EK-Unterschriftsdatum 10 April 2019

Startdatum 1 Juni 2019

Enddatum 31 Mai 2021

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten

€ 224 933,76

EU-Beitrag

€ 224 933,76

Koordiniert durch

UNIVERSITY OF BRISTOL
United Kingdom

Periodic Reporting for period 1 - COOPCAT (Cooperative Lewis base / Metal-Catalyzed Enantioselective Annulations)

Berichtszeitraum: 2019-06-01 bis 2021-05-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Five to seven-membered heterocycles are of immense use biologically and industrially. Heterocycles are present in all types of organic compounds of interest in electronics, optics, biology, pharmacology, material sciences, etc. Five to seven-membered heterocycles impart an important function in medicinal chemistry and serve as key templates for the development of many therapeutic agents. There are many common therapeutic uses of synthetic heterocycles such as antibacterial, trypanocidal, antimycobacterial, genotoxic, anti-HIV activity, herbicidal, anti-inflammatory, analgesic, antileishmanial agents, muscle relaxants, anticonvulsant, anticancer, antifungal antimalarial, antitubercular, hypnotics, anthelmintic, antidepressant, antitumoral, and insecticidal agents. The exploration of new bioactive heterocyclic analogs continues to be an area of intensive research in pharmaceutical chemistry. The project set out to devise new efficient ways to make such molecules.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

The initial approach to the target molecules turned out to be unsuccessful, but an alternative method based on organolithium photochemistry did deliver useful products, and two publications are in the process of being edited ready for dissemination.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

The alternative methods developed have shown that mild photochemical methods using LED irradiation can push forward the state of the art in synthetic photochemistry - this was not part of the original proposal, that was discovered while attempting to solve the problems that were encountered during the project. This aspect of the work has a significant future potential impact in synthesis as it will allow low energy bulbs to be used for heterocyclic synthesis in routes that employ reactive intermediates as chromophores.

Further project proposals will be developed in which such a reaction is employed as a key step.

photochemistry using LED