In this project, we have achieved several scientifically and industrially interesting results. For instance, we have built a collection of portable genetic modules (ChloroBricks) that has been applied during the construction of bacterial platforms for the production of high added-value chlorinated chemicals (including chlorinated sugars, nucleotides, and carboxylic acids). We have also made significant progress in the rational reprogramming of modular polyketide synthases to produce chlorinated polyketides (e.g. chlorinated triketide lactones) in both in vivo and in vitro assays. In a society that seeks more selective, ecological, and sustainable solutions for the manufacture of halogenated molecules, the biotechnological alternatives developed in this project could have some commercial relevance. Although no patent has been filed, for the time being, the receiving laboratory will continue to work on optimizing the results of the project and the subsequent exploitation of those results with exceptional commercial potential.
During the implementation of the project, we have carried out multiple activities aimed at communicating and disseminating the results of the research. One research article has been published and two additional articles are expected to be published in the coming months. All articles will be published in high-quality peer-reviewed journals under the Open Access framework and will include a reference to EU funding. The vision and results of the project have also been disseminated among scientific colleagues and collaborators at regular meetings and seminars, and among experts in the field at an international scientific conference. To bring research closer to non-specialized groups, we have collaborated in "Science is wonderful!", an outreach event organized by the European Commission aimed at European secondary school students
