Skip to main content

PAINTing the architecture of the totipotency gene network during early mammalian development

Project description

Genomic architecture in the embryo

Chromatin organisation is central for correct transcriptional activity and other key aspects of cell biology. However, the genomic architecture of totipotent cells in the early embryo remains uncharacterised. The aim of the EU-funded EmbryoPAINT project is to understand if precise genomic rearrangements drive cell fate decisions or if this is a stochastic process. Using 3D super-resolution microscopy and DNA paints, researchers will study the physical structure and architecture of totipotency and pluripotency genes in single stem cells in the whole embryo. Project results will provide important insight into the process of mammalian development.

Coordinator

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Net EU contribution
€ 162 806,40
Address
Meyerhofstrasse 1
69117 Heidelberg
Germany

See on map

Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Research Organisations
Other funding
€ 162 806,40