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Innovative Statistical modelling for a better Understanding of Longitudinal multivariate responses in relation to Omic datasets

Project description

Statistical tools help reveal relationships between omics data and traits

Scientists collect groups of -omic data to better understand the evolution of traits over time. Genomics, for example, is the study of the entire genome or all the genes of an organism, and transcriptomics is the study of the transcriptome, the complete set of RNA transcripts produced by the genome. Researchers then analyse both these datasets with traits of interest measured over time in long-term studies. The EU-funded ISULO project is developing advanced statistical methods to simultaneously analyse these two types of data as well as explore the interrelationships among -omic data sets for important new insights into evolution.

Objective

In medicine and agronomy, there is a growing interest in identifying biological mechanisms involved in the evolution of traits along time. Nowadays, this challenging objective is achieved through the acquisition of high-dimensional –omic datasets from various biological levels, and with the collection of phenotype measures along time on the same individuals, so-called longitudinal data. A new research focus is emerging with the objective to analyze jointly these two types of data. In this project, we propose to develop innovative statistical methods to simultaneously analyze these types of data and to deal with their respective characteristics. Novel methodologies will be developed by combining statistical concepts from linear mixed model and variable selection in a Bayesian framework, and by incorporating or inferring biological relationships. The first aim will focus on the analysis of one or more longitudinal outcomes with one –omic data. Flexible modeling for approximating time-varying covariate effects combined with variable selection approaches will be proposed. Thus, a better understanding of the relationships along time between the outcomes and the relevant covariates will be reached. The second objective is to investigate the integration of multiple –omic datasets for explaining one univariate outcome, then one longitudinal response variable, and finally multivariate longitudinal outcomes. Bayesian hierarchical modeling with prior distributions allowing to capture relationships among –omic datasets will be investigated and new relationships among –omic datasets will be explored. The developments and findings of this project research will greatly contribute to the statistical and biological domains. New generic statistical methods will be developed and will be available for transversal applications in various fields. Finally, this project will highlight the added value brought by a collaborative and interdisciplinary work with experienced researchers.

Coordinator

CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC
Net EU contribution
€ 275 619,84
Address
RUE SCHEFFER 42
75016 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
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Total cost
€ 275 619,84

Partners (1)