Project description
Explaining dynamics in breathing
How does consciousness shape breathing? What are the neural mechanisms underlying conscious control of breathing? Can breathing dynamics indicate conscious awareness? Breathing is one of the most crucial physiological mechanisms that may seem simple since it occurs mostly unconsciously. Yet, its underlying dynamics still cannot be understood. In an effort to shed light on fundamental issues surrounding breathing regulation, the EU-funded ConscBreathDynamics project proposes a cross-sectional and longitudinal study on the way consciousness shapes respiratory patterns. By applying a combination of basic and clinical neuroscience, electrophysiology, neuroimaging and computational tools, the research will focus on breathing in different kinds of disorders of consciousness to explain basic breathing dynamics.
Objective
Breathing is perhaps the most vital physiological function, and it is occurring mainly unconsciously. Yet, despite the deceptive simplicity of breathing, it is an intricate behaviour influence by conscious top-down control and vigilance state. How consciousness shape breathing? What are the neural mechanisms underlying conscious control of breathing? Can breathing dynamics indicate on conscious awareness? We aim to address these questions by employing basic and clinical neuroscience approaches in combination with electrophysiology, neuroimaging and advanced computational tools. Disorders of consciousness (DOC) including vegetative state (VS)/unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) offer a unique model to investigate the relationship between consciousness and breathing, by providing a rare opportunity for cross-sectional and longitudinal tracking of breathing dynamics during recovery of consciousness. In the proposed research, we first aim to characterize the interaction between breathing and consciousness state. To do this we will record continues respiration during 24-hour from healthy individuals and DOC patients. Next, we intend to elucidate the neural mechanism underlying conscious regulation of breathing, by recording electroencephalogram (EEG) and functional resonance magnetic imaging (fMRI) activity during a multimodal (olfaction, audition and vision) paradigm designed to consciously and unconsciously trigger respiratory change. Last, we plan to investigate whether breathing dynamics can be used as a diagnostic and potentially prognostic tool to detect awareness in DOC patients, by developing an automated respiratory-based classifier differentiating between UWS and MCS patients. The significance of this study is two-fold; addressing fundamental questions in breathing regulation, and utilizing the interplay between basic physiological function and consciousness to better human condition.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75013 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.