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Intra-tumoral heterogeneity in NRAS-driven metastatic melanoma

Project description

Understanding multi-step reprogramming leading to metastatic melanoma

Cancer metastases are responsible for 90 % of cancer-related deaths. The metastatic process involves multi-step reversible non-genetic reprogramming, allowing cancer cells to migrate, invade and actively adapt to the varying microenvironments. Understanding metastasis requires methodologies to study non-genetic reprogramming in space and time at the single-cell resolution. The EU-funded INHuMAN project will exploit single-cell profiling and lineage tracing to perform a longitudinal analysis of the diversity and trajectories of melanoma cell states during metastatic dissemination in a clinically relevant mouse model of melanoma. The research will unravel the gene regulatory networks underlying metastatic cell states to identify targets that contribute to early steps in the metastatic process.

Call for proposal

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Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
EU contribution
€ 166 320