Understanding multi-step reprogramming leading to metastatic melanoma
Cancer metastases are responsible for 90 % of cancer-related deaths. The metastatic process involves multi-step reversible non-genetic reprogramming, allowing cancer cells to migrate, invade and actively adapt to the varying microenvironments. Understanding metastasis requires methodologies to study non-genetic reprogramming in space and time at the single-cell resolution. The EU-funded INHuMAN project will exploit single-cell profiling and lineage tracing to perform a longitudinal analysis of the diversity and trajectories of melanoma cell states during metastatic dissemination in a clinically relevant mouse model of melanoma. The research will unravel the gene regulatory networks underlying metastatic cell states to identify targets that contribute to early steps in the metastatic process.
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