New ways to control biological networks
Biological elements interact with others to form networks. The ability to control their dynamics is vital for scientific research, particularly for the pharmaceutical and medical industry. Despite advances in network science, the requisite computational approaches are still lacking. The NETCONTROLOGY project will explore how biological networks can be controlled with focus on two cutting-edge medical studies: to reprogram cancer networks (finding druggable vulnerabilities to improve anticancer therapeutics) and target the enzymatic sources of relevant oxidative stress to support neuroprotection in stroke. To do so, the project will develop nonlinear, quantitative and dynamic network models for biological networks with multiple regulatory mechanisms. It will also develop different measures to compare networks based on their controllability.
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