Project description
A fast spectroscopy method for mutation detection
DNA sequencing and PCR comprise the gold standard methods for the identification of genetic mutations. However, there is a constant search for fast, inexpensive and accurate techniques to detect mutations at the molecular level. The EU-funded 2D-MES project proposes to detect base mutations in DNA or RNA using graphene-based biosensors. The molecules under test are attached to a graphene nanoribbon (GNR) in an aqueous environment, and their transport characteristics are recorded. The obtained transport molecular fingerprints of the mutated DNA/RNA on the GNR will lay the groundwork for the development of an innovative tool with high spatial resolution.
Objective
In this project, Dr. Reza Rezapour will address, by a combination of quantum mechanical and classical simulations combined with electronic transport techniques, the sensing capabilities of graphene-based biosensors to identify DNA and RNA mutations in PNA-functionalized graphene nanoribbons.
In the search for fast, inexpensive and accurate tools for DNA sequencing and mutation recognition, computational techniques are being fruitfully used to address detection at the molecular level. We will extended the 2D-MES method previously developed by Dr. Rezapour to the identification, not only of single normal and mutated nucleobases on graphene, but of base mutations in DNA or RNA fragments attached to a graphene nanoribbon (GNR) in an aqueous environment. To this aim, after the quantum mechanical (QM) calculation of the transport characteristics of a nucleobases-GNR system in vacuum, we will study: (1) large DNA/RNA fragments in a solvent by molecular mechanics (MM) classical methods (to study mutation stability in a given sequence) and (2) the most stable mutations on a GNR by novel hybrid QM/MM simulations combining the accuracy of QM with the speed of MM.
Besides providing new insight on fundamental aspects of physical processes at the interface between solids, liquids and biomolecules, the project will train Dr. Rezapour in advanced new techniques, complementary to his current expertise; and it will provide the community with a new and efficient QM/MM-electronic transport tool by the implementation of transport routines into the existent QM/MM package. The obtained QM/MM transport molecular fingerprints of the mutated DNA/RNA on the GNR will serve as a proof-of-concept for the design of a graphene-based bionsensor fast, inexpensive, and with high spatial resolution.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics RNA
- natural sciences physical sciences optics spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
18071 GRANADA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.