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Targeted intracellular delivery of antitubercular agents by functionalized nanocapsules

Descripción del proyecto

Administración intracelular de fármacos basada en la nanotecnología contra la «Mycobacterium tuberculosis»

La tuberculosis (TBC) es un gran problema de salud pública mundial con un aumento alarmante de casos de multirresistencia a fármacos. La TBC la causa la «Mycobacterium tuberculosis», que puede sobrevivir en las células hospedadoras, sobre todo macrófagos. La eliminación intracelular de estas bacterias es más eficaz con la administración de tratamientos dirigidos a las células hospedadoras. El proyecto financiado con fondos europeos TBNANO pretende desarrollar y evaluar nanocápsulas cargadas de fármacos antituberculosos capaces de dirigirse a las moléculas de la célula hospedadora. La superficie de las nanocápsulas se funcionalizará con péptidos dirigidos a los macrófagos y derivados de la manosa. Esta administración de fármacos basada en la nanotecnología mejorará la absorción celular por parte de los macrófagos del hospedador, lo que resultará en que se dirija de forma eficaz a las microbacterias intracelulares, a la vez que reduce los efectos secundarios no deseados del fármaco.

Objetivo

Tuberculosis (TB) is still a major public health problem worldwide. It is estimated that more than one-quarter of the world's population is infected with this airborne infectious disease. Moreover, the increase of multidrug- and extensively drug-resistant TB is alarming. TB is caused by Mycobacterium tuberculosis, an intracellular pathogen that can survive in host cells, mainly in macrophages. The uptake of the antitubercular drugs by infected host cells is limited. The orally or intravenously administered drugs are distributed throughout the body causing side effects and the majority of the drug molecules do not reach their targets. The elimination of the intracellular bacteria could be more efficient with host cell directed delivery. The TBNANO project aims to develop and in vitro evaluate antitubercular agent-loaded nanocapsules decorated with host cell targeting molecules. For this purpose, naturally occurring, biocompatible and biodegradable polysaccharide nanocapsules loaded with a recently approved anti-TB drug (bedaquiline) and antimicrobial peptides will be used. The surface of the nanocapsules will be functionalized with macrophage targeting ligands, such as peptides and mannose derivatives. With such nanotechnology-based drug delivery system, enhanced cellular uptake can be achieved by the host cell macrophages, therefore, the anti-TB agent can reach the intracellular bacteria as site of action. This approach leads to increased bioavailability and selectivity of the drugs while reducing their undesirable side effects. The proposed project could provide a breakthrough step in nanotechnology-based TB treatment to get closer to a world free of TB. Furthermore, this multidisciplinary project provide valuable transfer of knowledge to the host institution, as well as advanced training of the young researcher in the field of nanomaterial science to broaden her expertise in drug delivery systems.

Régimen de financiación

MSCA-IF-EF-ST - Standard EF

Coordinador

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Aportación neta de la UEn
€ 172 932,48
Dirección
CALLE SERRANO 117
28006 Madrid
España

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Región
Comunidad de Madrid Comunidad de Madrid Madrid
Tipo de actividad
Research Organisations
Enlaces
Coste total
€ 172 932,48