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Comprehensive Mechanisms of Bacterial Antibiotic Tolerance in Mycobacterium Tuberculosis

Project description

Tuberculosis: a persistent menace

Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis (Mtb), is the leading single infectious cause of death worldwide, claiming more than one million lives per year. Treatment is complicated by long duration, primary treatment failure, disease recurrence, and increasingly-prevalent drug resistance. All of these complications are linked to a phenomenon known as phenotypic tolerance, by which some bacteria within a drug-susceptible population transiently survive exposure to a drug without acquiring heritable resistance mutations. Tolerant cells—called persisters—are thus prime targets for new therapeutics that could improve outcomes in TB, but the mechanisms by which they survive would-be lethal antibiotic exposure remain a mystery. To understand this phenomenon, COMBATTB is uncovering the genetic factors and metabolic pathways that lead to phenotypic tolerance in Mycobacterium tuberculosis. The thorough understanding of these pathways will establish an essential foundation for building better, faster TB drug regimens that could help save countless lives.


Net EU contribution
€ 212 933,76
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom

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London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00