Descrizione del progetto
Biomateriali su nanoscala per la rigenerazione del tessuto osseo
Lo sviluppo di nuovi biomateriali nell’ingegneria tissutale richiede uno sforzo interdisciplinare. Il biomateriale deve imitare la funzione della matrice extracellulare, comprese le complesse interazioni cellulari e le proprietà fisiche del substrato. L’obiettivo del progetto PONS, finanziato dall’UE, consiste nel fabbricare un substrato nanoibrido complesso organico-inorganico come impianto osseo nell’ingegneria tissutale. Tale substrato sarà composto da tre elementi, ovvero una particella inorganica che contiene vettori molecolari biologici, un polisaccaride e una proteina. Saranno funzionalizzati idrossidi doppi a strato attraverso i vettori molecolari biologici per il rilascio controllato di molecole biologiche che guideranno le interazioni tra cellula e materiale.
Obiettivo
The development of new biomaterials in bone tissue engineering requires an interdisciplinary joint-venture combining material and biomedical sciences. The aim of the regenerative biomaterial is to repair the functional defect or damages by generation of a bone substitute. The biomaterial has to be highly engineered at the molecular level to mimic the function of the extracellular matrix including complex cell-material interactions and physical properties of the scaffold. The focus of this proposal is to fabricate an organic-inorganic complex nanohybrid scaffold as a bone implant for applications in tissue engineering. The nanohybrid scaffold is based on three components: an inorganic particle containing biological carrier molecules (BCM), polysaccharide (cellulose) and protein (collagen). Layered-double hydroxides (LDH) inorganic particles will be functionalized with BCM allowing controlled release of biological molecules that will direct cell-material interactions. Polysaccharides (Pol)–Protein (Pro) biomaterials reinforced with LDH-BCM will be fabricated and tested in ectopic bone formation analysis technology which will translate to clinical trials. In essence, Pol-PrO complex reinforced LDH-BCM Nanohybrid Scaffold (PONS) will be developed as regenerative biomaterial in bone tissue engineering and will incorporate cutting edge stem cell technologies, engineering of advanced materials and controlled delivery of biomolecules in vitro and in vivo.
Campo scientifico
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.
- medical and health sciencesmedical biotechnologytissue engineering
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- natural sciencesbiological sciencesbiochemistrybiomoleculescarbohydrates
- engineering and technologyindustrial biotechnologybiomaterials
- medical and health sciencesmedical biotechnologyimplantsartificial bone
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-IF-EF-ST - Standard EFCoordinatore
3000 Leuven
Belgio