Project description
Look out, fungi – expedited rollout of exterminators is on its way
Although most fungi are not pathogenic to plants, the very few that are cause significant damage. Fungi destroy about a third of global food crops annually, not only affecting our food supply but also damaging economies and contributing to global poverty. The development of fungicides about a half a century ago was instrumental in fighting this threat, but fungicide resistance and highly aggressive strains are a growing problem. The EU-funded MAHT-FunSST project will bring fungicide development into the age of labs-on-a-chip with a novel high-throughput microfluidic screening platform that will help protect our global food supply already battling survival in the face of global climate change.
Objective
Fungicide development and screening is stuck in an innovation gap, in which it incurs staggering expenses and takes many years to get a fungicide to market, furthermore, many pathogens develop resistance against fungicides which necessitates the sensitivity screening and recalled fungicides. The present proposal is conceptualized to bridge the gap for high throughput (HT) screening of fungicides effectively, by designing the novel lab-on-chip device. Specifically, we will assess (i) baseline sensitivity of fungicides against phyto-pathogenic fungi, (ii) response of fungi to different doses of fungicides, (iii) antifungal effects induced on fungal conidia, (iv) specific enzyme inhibition by fungicide. The fungicide screening lab-on-a-chip will address the large and currently unmet need to model fungicide screening device, regarding the spatial and mechanical cues important for conidia. The project will be based on the state-of-the-art technical expertise of ELVESYS in microfluidic chip design and fabrication and will fully integrate the Experienced Researcher’s (ER) strong expertise with agricultural plant pathology, molecular plant-microbe interactions and fungicides design and screening to develop a HT fungicide screening chip. Testing and validation of the product will be by perfusion using a set of candidate fungicides. The development of lab-on-a-chip technology will result in increasing the pre- and in-field HT screening of fungicides for their efficacy, optimal dosing and toxicity. The device will minimize the cost of fungicide development and screening, thus reducing the economic burden in the EU area as well as having large implications on improving the production of food globally. Through this opportunity the ER will be immersed in a richly entrepreneurial environment at ELVESYS and exposed to marketing concepts. Together, these experiences will provide the ER with the optimal environment to become a leader in next generation tools for fungicide screening.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology other engineering and technologies microtechnology lab on a chip
- natural sciences biological sciences microbiology mycology
- medical and health sciences basic medicine pathology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-SE - Society and Enterprise panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75011 PARIS
France
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.