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Deciphering ubiquitin-dependent regulation of Golgi homeostasis control in neurodegeneration

Project description

Dissecting Golgi fragmentation in neurodegenerative disorders

The Golgi apparatus is an organelle in eukaryotic cells that processes and sorts proteins destined for the plasma membrane or for secretion. Therefore, it plays a key role in cellular homeostasis and cell-to-cell communication. The Golgi is a highly dynamic organelle that maintains a specific morphology but becomes irreversibly fragmented in neurodegenerative conditions such as Alzheimer’s disease. The scope of the EU-funded UbiGolD project is to investigate the mechanisms that regulate Golgi fragmentation. Researchers will focus on a novel proteasomal degradation mechanism and its role in Golgi integrity under changing conditions. Results will shed light on neurodegeneration and pave the way towards new treatments.

Coordinator

WEIZMANN INSTITUTE OF SCIENCE
Net EU contribution
€ 185 464,32
Address
Herzl Street 234
7610001 Rehovot
Israel

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 185 464,32