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DNA-origami frame platform for co-evolution ligand selection

Project description

An innovative platform for the design of highly selective ligands

The development of ligands with high specificity against a particular target is of particular interest to biotechnology and therapeutics. However, producing high-affinity ligands that target many epitopes of a single molecule is challenging. The EU-funded APTAFRAME project has developed a new platform for the discovery of antibodies and aptamer nucleotides or peptides that bind to specific molecules. This platform combines DNA origami structures as a molecular 3D framework with structural feedback from cryo-electron microscopy reconstructions to aid the design of cooperative ligands for highly specific target recognition. The APTAFRAME platform is expected to find application in biosensor development, proteome analysis and diagnostics.

Coordinator

UNITED KINGDOM RESEARCH AND INNOVATION
Net EU contribution
€ 212 933,76
Address
Polaris House North Star Avenue
SN2 1FL Swindon
United Kingdom
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Swindon