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DNA interstrand crosslink repair and chromatin remodelling

Project description

Dissecting the mechanism of DNA lesion repair

Genomic lesions known as interstrand DNA crosslinks (ICLs) form by covalent linkage between the two opposite strands of DNA. ICLs are highly toxic as they can interfere with DNA replication and transcription and can lead to conditions like Fanconi anaemia if left unrepaired. Funded by the EU, the ICL CHROM project aims to delineate the process of ICL repair and identify the key proteins involved, including nucleosome remodelling proteins and histone chaperones. Through novel techniques, scientists will unveil the regulatory mechanism of ICL repair and how cells remodel their chromatin to address ICLs.

Coordinator

UNIVERSITY OF DUNDEE
Net EU contribution
€ 224 933,76
Address
Nethergate
DD1 4HN Dundee
United Kingdom

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Region
Eastern Scotland Angus and Dundee City
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00