DNA interstrand crosslink repair and chromatin remodelling

Project description

Dissecting the mechanism of DNA lesion repair

Genomic lesions known as interstrand DNA crosslinks (ICLs) form by covalent linkage between the two opposite strands of DNA. ICLs are highly toxic as they can interfere with DNA replication and transcription and can lead to conditions like Fanconi anaemia if left unrepaired. Funded by the EU, the ICL CHROM project aims to delineate the process of ICL repair and identify the key proteins involved, including nucleosome remodelling proteins and histone chaperones. Through novel techniques, scientists will unveil the regulatory mechanism of ICL repair and how cells remodel their chromatin to address ICLs.

Fields of science

• natural sciences › biological sciences › genetics › DNA
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › clinical medicine › oncology
• medical and health sciences › clinical medicine › hematology
• natural sciences › biological sciences › genetics › genomes

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

See other projects for this call

Funding Scheme

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Coordinator

UNIVERSITY OF DUNDEE

Net EU contribution

€ 224 933,76

Address

Nethergate
DD1 4HN Dundee
United Kingdom

Region

Eastern Scotland › Angus and Dundee City

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00