Project description DEENESFRITPL A plant's biological clock may let it know when to give birth to new organs Plants have their own system of multipotent stem cells. Meristematic cells in the shoot apical meristem (SAM) are responsible for the development of all the above-ground organs of a plant. Creation of organs (organogenesis) occurs throughout a plant's life and is modulated by cues from the environment, including changes in temperature and light. Plants, like animals, also have their own circadian clock that acts as a complex developmental manager. Clock-SAM is investigating the link between circadian rhythms and SAM activity using changes in regulation of gene expression for clues. Insight into mechanisms controlling plant organogenesis could have important applications in boosting productivity for crops of interest. Show the project objective Hide the project objective Objective Plant growth and organogenesis are coordinated by stem cells located in specialized tissues known as meristems. Virtually all the aerial parts of the plant derive from stem cells located in niches at the shoot apical meristem (SAM), where they process internal and external cues to sustain their function. As cells are continuously produced at SAM, it is essential for plants to precisely regulate the timing of proliferation as development and plant organogenesis occurs over time throughout the life cycle. The circadian clock is the primary timing device that enables an organism to measure the pass of the time to precisely coordinate biological activities with the internal cues and its surrounding environment. Despite the importance of stem cell function, the mechanisms controlling the timing of SAM activity in synchronization with the environment remain essentially unknown. we propose to investigate the role of the circadian clock as a flexible biological metronome orchestrating the SAM activity in plants. The Clock-SAM proposal aims to generate a road-map of clock function, defining circadian similarities and divergences among the different functional states at the SAM and establishing the correlation between the circadian pace of the clock and cell fate and specification. We will follow an ambitious integrative approach combining epigenetic and transcriptional regulatory mechanisms to understand stem cell function. Our studies will thus answer a fundamental question in plant cell biology by determining how the plant is temporally constructed in our rotating world. The results from this proposal will provide a framework that can be tested for regulating plant productivity and survival in different environmental conditions. Hence, in the long term our findings could be applied to crops of agronomical interest. Fields of science natural sciencesbiological sciencescell biologysocial scienceseconomics and businesseconomicsproduction economicsproductivitymedical and health sciencesmedical biotechnologycells technologiesstem cellsagricultural sciencesagriculture, forestry, and fisheriesagriculture Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2018 - Individual Fellowships Call for proposal H2020-MSCA-IF-2018 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator CENTRE DE RECERCA EN AGRIGENOMICA CSIC-IRTA-UAB-UB Net EU contribution € 172 932,48 Address Parc de recerca de l uab campus uab edifici crag bellaterra 08193 Cerdanyola del valles Spain See on map Region Este Cataluña Barcelona Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
