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Effects of 3D topographies on mechanosensing in intestine epithelial architecture and dynamics

Project description

Molecular players in intestinal epithelial topography

The epithelium is a widespread tissue that covers all the outer and inner surfaces of our body including the skin and the intestine. Apart from its role as a physical barrier, the intestinal epithelium serves to regulate nutrient uptake and interacts with microbiota. However, little is known regarding the mechanisms that determine its architecture and dynamics. The EU-funded TOPOGRAPHYSENSING project is examining the role of the epithelial cell adhesion molecule (EpCAM), a transmembrane glycoprotein. Researchers will assess how EpCAM senses mechanical cues from the microenvironment to drive the spatial organisation of epithelial cells in the intestine.

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Net EU contribution
€ 134 600,08
Address
Rue Michel Ange 3
75794 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 62 107,76