Programme for EArly-stage Researchers in Lille

Información del proyecto

PEARL

Identificador del acuerdo de subvención: 847568

DOI

10.3030/847568

Proyecto cerrado

Fecha de la firma de la CE 20 Mayo 2019

Fecha de inicio 9 Septiembre 2019

Fecha de finalización 8 Septiembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 4 881 600,00

Aportación de la UE

€ 2 440 800,00

Coordinado por

UNIVERSITE DE LILLE
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (6)

Report on ethic issues for call 1

A short description on how the ethics procedure in place (as described in Annex I of the Grant Agreement) was followed and if relevant, the adaptations made. This part should also include a description of the role and composition of the ethics committee if such a committee was involved. An overview table based on the following structure (only for the successful fellows): name of the researcher; the title of research project with ethical issues; the ethics area(s) concerned; conditions to be fulfilled for funding and ethics requirements to be monitored during implementation; follow-up during the implementation. Only those research projects having ethics issues need to be detailed in this table.

Guidelines and forms for candidates & selection bodies
Final ethics report

The Final Ethics Report should summarise the ethics procedure followed during the entire project lifecycle and focus on the adaptation made and lessons learned. The report should also confirm that all required approvals/authorisations were obtained and that the research was conducted in compliance with the ethical principles and applicable international, EU and national law under H2020.

Report for call 1 on dissemination activities

Dates/Interval of call publication and dissemination channels/means (supporting documents are required as images, screen shots, photos from events). Flyers, brochures, or other information produced for dissemination of the call Presentations held at conferences and/or meetings and/or other events Articles published in the press (please list and attach only main articles) Any other means for advertising the programme

Report on ethic issues for call 2

A short description on how the ethics procedure in place (as described in Annex I of the Grant Agreement) was followed and if relevant, the adaptations made. This part should also include a description of the role and composition of the ethics committee if such a committee was involved. An overview table based on the following structure (only for the successful fellows): name of the researcher; the title of research project with ethical issues; the ethics area(s) concerned; conditions to be fulfilled for funding and ethics requirements to be monitored during implementation; follow-up during the implementation. Only those research projects having ethics issues need to be detailed in this table.

Report for call 2 on dissemination activities

Dates/Interval of call publication and dissemination channels/means (supporting documents are required as images, screen shots, photos from events). Flyers, brochures, or other information produced for dissemination of the call Presentations held at conferences and/or meetings and/or other events Articles published in the press (please list and attach only main articles) Any other means for advertising the programme

Websites, patent fillings, videos etc. (2)

Link to Euraxess website for call 2

Inform the Project Officer on publishing each call for proposals, by sending the link to the Euraxess website and a screen shot of the related call announcement.

Link to Euraxess website for Call 1

Inform the Project Officer on publishing each call for proposals, by sending the link to the Euraxess website and a screen shot of the related call announcement.

Publicaciones

Peer reviewed articles (39)

Structure determination of riboflavin by synchrotron high-resolution powder X-ray diffraction

Autores: Mathieu Guerain, Frédéric Affouard, Charline Henaff, Catherine Dejoie, Florence Danède, Juergen Siepmann, Florence Siepmann, Jean-François Willart
Publicado en: Acta Crystallographica Section C Structural Chemistry, Edición 77, 2025, Página(s) 800-806, ISSN 2053-2296
Editor: International Union of Crystallography (IUCr)
DOI: 10.1107/s2053229621012171

Wafer-Scale Performance Mapping of Magnetron-Sputtered Ternary Vanadium Tungsten Nitride for Microsupercapacitors

Autores: Khac Huy Dinh, Kevin Robert, Joelle Thuriot-Roukos, Marielle Huvé, Pardis Simon, David Troadec, Christophe Lethien, Pascal Roussel
Publicado en: Chemistry of Materials, Edición 35, 2023, Página(s) 8654-8663, ISSN 0897-4756
Editor: American Chemical Society
DOI: 10.1021/acs.chemmater.3c01803

Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins

Autores: Stefania Robakiewicz, Clarisse Bridot, Sonia Serna, Ana Gimeno, Begoña Echeverria, Sandra Delgado, Jérôme de Ruyck, Shubham Semwal, Diego Charro, Ann Dansercoer, Kenneth Verstraete, Mikel Azkargort
Publicado en: Glycobiology, Edición 31, 2021, Página(s) 1005-1017, ISSN 1460-2423
Editor: Oxford University Press (OUP)
DOI: 10.1093/glycob/cwab027

A Step‐by‐Step Guide for the Production of Recombinant Fluorescent TAT‐HA‐Tagged Proteins and their Transduction into Mammalian Cells

Autores: Christer Abou Anny, Sébastien Nouaille, Régis Fauré, Céline Schulz, Corentin Spriet, Isabelle Huvent, Christophe Biot, Tony Lefebvre
Publicado en: Current Protocols, Edición 4, 2024, ISSN 2691-1299
Editor: Wiley
DOI: 10.1002/cpz1.1016

Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors

Autores: Eva-Maria Krammer, Clarisse Bridot, Sonia Serna, Begoña Echeverria, Shubham Semwal, Benoît Roubinet, Kim van Noort, Ruud H.P. Wilbers, Gleb Bourenkov, Jérôme de Ruyck, Ludovic Landemarre, Niels Re
Publicado en: Journal of Biological Chemistry, Edición 299, 2025, Página(s) 104627, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2023.104627

Regioselective and Stereoselective Synthesis of Parthenolide Analogs by Acyl Nitroso-Ene Reaction and Their Biological Evaluation against Mycobacterium tuberculosis

Autores: Bruna Gioia, Francesca Ruggieri, Alexandre Biela, Valérie Landry, Pascal Roussel, Catherine Piveteau, Florence Leroux, Ruben C. Hartkoorn, Nicolas Willand
Publicado en: International Journal of Molecular Sciences, Edición 24, 2025, Página(s) 17395, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242417395

The embedded research librarian: a project partner

Autores: Romain Féret, Marie Cros
Publicado en: LIBER Quarterly: The Journal of the Association of European Research Libraries, Edición 29, 2022, Página(s) 1-20, ISSN 2213-056X
Editor: Ligue des Bibliotheques Europeennes de Recherche
DOI: 10.18352/lq.10304

<i>In Vitro</i> and <i>Ex Vivo</i> Models for Assessing Drug Permeation across the Cornea

Autores: Inès De Hoon, Rabah Boukherroub, Stefaan C. De Smedt, Sabine Szunerits, Félix Sauvage
Publicado en: Molecular Pharmaceutics, Edición 20, 2023, Página(s) 3298-3319, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.3c00195

Impact of Hot-Melt Extrusion on Glibenclamide’s Physical and Chemical States and Dissolution Behavior: Case Studies with Three Polymer Blend Matrices

Autores: Nina Zupan, Ines Yous, Florence Danede, Jeremy Verin, Mostafa Kouach, Catherine Foulon, Emeline Dudognon, Susanne Florin Muschert
Publicado en: Pharmaceutics, Edición 16, 2025, Página(s) 1071, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16081071

Process-constrained batch Bayesian approaches for yield optimization in multi-reactor systems

Autores: Markus Grimm, Sébastien Paul, Pierre Chainais
Publicado en: Computers &amp; Chemical Engineering, Edición 189, 2024, Página(s) 108779, ISSN 0098-1354
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.compchemeng.2024.108779

Small-angle X-ray scattering of engineered antigen-binding fragments: the case of glycosylated Fab from the Mannitou IgM antibody

Autores: Shubham Semwal, Maria Karamolegkou, Stéphanie Flament, Nessim Raouraoua, Kenneth Verstraete, Aurélien Thureau, Frank Wien, Fabrice Bray, Savvas N. Savvides, Julie Bouckaert
Publicado en: Acta Crystallographica Section F Structural Biology Communications, Edición 81, 2025, Página(s) 19-29, ISSN 2053-230X
Editor: John Wiley and Sons Ltd
DOI: 10.1107/s2053230x24012159

Natural Antibodies: Protecting Role of IgM in Glioblastoma and Brain Tumours

Autores: Shubham Semwal, Rabah Boukherroub, Savvas N. Savvides, Julie Bouckaert
Publicado en: Current Pharmaceutical Design, Edición 27, 2021, Página(s) 4515-4529, ISSN 1381-6128
Editor: Bentham Science Publishers
DOI: 10.2174/1381612827666210728103524

Advances on Microsupercapacitors: Real Fast Miniaturized Devices toward Technological Dreams for Powering Embedded Electronics?

Autores: Khac Huy Dinh, Pascal Roussel, Christophe Lethien
Publicado en: ACS Omega, Edición 8, 2023, Página(s) 8977-8990, ISSN 2470-1343
Editor: American Chemical Society (ACS)
DOI: 10.1021/acsomega.2c07549

Convolutional neural network application on a new middle Eocene radiolarian dataset

Autores: Veronica Carlsson, Taniel Danelian, Martin Tetard, Mathias Meunier, Pierre Boulet, Philippe Devienne, Sandra Ventalon
Publicado en: Marine Micropaleontology, Edición 183, 2025, Página(s) 102268, ISSN 0377-8398
Editor: Elsevier BV
DOI: 10.1016/j.marmicro.2023.102268

Periodic membrane fractionation of freshwater organic matter reveals various reactivity patterns during chlorine/chloramine disinfection

Autores: Karlien Dejaeger, Marjolein Vanoppen, Justine Criquet, Gabriel Billon, Cécile Vignal, Emile R. Cornelissen
Publicado en: Separation and Purification Technology, Edición 355, 2024, Página(s) 129635, ISSN 1383-5866
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.seppur.2024.129635

Biocatalytic Regioselective <i>O</i>‐acylation of Sesquiterpene Lactones from Chicory: A Pathway to Novel Ester Derivatives

Autores: J. Rodriguez Mosheim, F. Ruggieri, C. Humeau, P. Hance, N. Willand, J. L. Hilbert, E. Heuson, R. Froidevaux
Publicado en: ChemBioChem, Edición 25, 2025, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202300722

Artificial intelligence applied to the classification of eight middle Eocene species of the genus <i>Podocyrtis</i> (polycystine radiolaria)

Autores: Veronica Carlsson, Taniel Danelian, Pierre Boulet, Philippe Devienne, Aurelien Laforge, Johan Renaudie
Publicado en: Journal of Micropalaeontology, Edición 41, 2022, Página(s) 165-182, ISSN 2041-4978
Editor: Copernicus GmbH
DOI: 10.5194/jm-41-165-2022

Metaproteomics identifies key cell wall degrading enzymes and proteins potentially related to inter-field variability in fiber quality during flax dew retting

Autores: S. Mukherjee, E. Goulas, A. Creach, F. Krzewinski, D. Galinousky, A.-S. Blervacq, P. D’Arras, S. Ratahiry, A. Menuge, D. Soulat, J.-M. Saliou, A.-S. Lacoste, S. Hawkins, S. Grec
Publicado en: Industrial Crops and Products, Edición 222, 2024, Página(s) 119907, ISSN 0926-6690
Editor: Elsevier BV
DOI: 10.1016/j.indcrop.2024.119907

Morphometrics and machine learning discrimination of the middle Eocene radiolarian species Podocyrtis chalara, Podocyrtis goetheana and their morphological intermediates

Autores: Francisco Pinto, Veronica Carlsson, Mathias Meunier, Bert Van Bocxlaer, Hammouda Elbez, Marie Cueille, Pierre Boulet, Taniel Danelian
Publicado en: Marine Micropaleontology, Edición 185, 2025, Página(s) 102293, ISSN 0377-8398
Editor: Elsevier BV
DOI: 10.1016/j.marmicro.2023.102293

Tracking flax dew retting by infrared vibrational spectroscopy combined with a powerful multivariate statistical analysis

Autores: Suvajit Mukherjee, Estelle Goulas, Isabelle De Waele, Anne Créach, Simon Hawkins, Sébastien Grec, Anne-Sophie Blervacq
Publicado en: Industrial Crops and Products, Edición 227, 2025, Página(s) 120798, ISSN 0926-6690
Editor: Elsevier BV
DOI: 10.1016/j.indcrop.2025.120798

Sensorimotor Synchronization in Healthy Aging and Neurocognitive Disorders

Autores: Andres von Schnehen, Lise Hobeika, Dominique Huvent-Grelle, Séverine Samson
Publicado en: Frontiers in Psychology, Edición 13, 2022, ISSN 1664-1078
Editor: Frontiers Research Foundation
DOI: 10.3389/fpsyg.2022.838511

Sub-millielectronvolt Line Widths in Polarized Low-Temperature Photoluminescence of 2D PbS Nanoplatelets

Autores: Pengji Li, Leon Biesterfeld, Lars F. Klepzig, Jingzhong Yang, Huu Thoai Ngo, Ahmed Addad, Tom N. Rakow, Ruolin Guan, Eddy P. Rugeramigabo, Ivan Zaluzhnyy, Frank Schreiber, Louis Biadala, Jannika Lauth
Publicado en: Nano Letters, Edición 24, 2025, Página(s) 16293-16300, ISSN 1530-6984
Editor: American Chemical Society
DOI: 10.1021/acs.nanolett.4c04402

PmForecast: leveraging temporal LSTM to deliver in situ air quality predictions

Autores: Maryam Rahmani, Suzanne Crumeyrolle, Nadége Allegri-Martiny, Amir Taherkordi, Romain Rouvoy
Publicado en: Environmental Science and Pollution Research, Edición 31, 2024, Página(s) 51760-51773, ISSN 1614-7499
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s11356-024-34623-w

High Capacitance Porous Ruthenium Nitride Films with High Rate Capability for Micro‐Supercapacitors

Autores: Khac Huy Dinh, Grace Whang, Marielle Huve, David Troadec, Antoine Barnabé, Bruce Dunn, Pascal Roussel, Christophe Lethien
Publicado en: Small, 2024, ISSN 1613-6810
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202402607

Unveiling the presence of endocrine disrupting chemicals in northern French soils: Land cover variability and implications

Autores: L.M. Wakim, F. Occelli, M. Paumelle, D. Brousmiche, L. Bouhadj, D. Cuny, A. Descat, C. Lanier, A. Deram
Publicado en: Science of The Total Environment, Edición 913, 2024, Página(s) 169617, ISSN 0048-9697
Editor: Elsevier BV
DOI: 10.1016/j.scitotenv.2023.169617

Nanofeather ruthenium nitride electrodes for electrochemical capacitors

Autores: Huy Dinh Khac, Grace Whang, Antonella Iadecola, Houssine Makhlouf, Antoine Barnabé, Adrien Teurtrie, Maya Marinova, Marielle Huvé, Isabelle Roch-Jeune, Camille Douard, Thierry Brousse, Bruce Dunn, P
Publicado en: Nature Materials, Edición 23, 2024, Página(s) 670-679, ISSN 1476-1122
Editor: Nature Publishing Group
DOI: 10.1038/s41563-024-01816-0

Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters

Autores: Alexandre Barras, Félix Sauvage, Inès de Hoon, Kevin Braeckmans, Dawei Hua, Gaëtan Buvat, Juan C. Fraire, Christophe Lethien, J. Sebag, Michael Harrington, Amar Abderrahmani, Rabah Boukherroub, Ste
Publicado en: Nanoscale Horizons, Edición 6, 2024, Página(s) 449-461, ISSN 2055-6756
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/d1nh00157d

Discovery of Anti-Coronavirus Cinnamoyl Triterpenoids Isolated from Hippophae rhamnoides during a Screening of Halophytes from the North Sea and Channel Coasts in Northern France

Autores: Malak Al Ibrahim, Zachee Louis Evariste Akissi, Lowiese Desmarets, Gabriel Lefèvre, Jennifer Samaillie, Imelda Raczkiewicz, Sevser Sahpaz, Jean Dubuisson, Sandrine Belouzard, Céline Rivière, Karin
Publicado en: International Journal of Molecular Sciences, Edición 24, 2025, Página(s) 16617, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242316617

Mechanical and functional characterisation of a 3D porous biomimetic extracellular matrix to study insulin secretion from pancreatic β-cell lines

Autores: Leonid Pliner, Nathan Laneret, Meryl Roudaut, Alejandra Mogrovejo-Valdivia, Elodie Vandenhaute, Nathalie Maubon, Robert-Alain Toillon, Youness Karrout, Anthony Treizebre, Jean-Sébastien Annicotte
Publicado en: In vitro models, Edición 3, 2024, Página(s) 205-218, ISSN 2731-3441
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s44164-024-00078-z

Electricity-driven selectivity in the photocatalytic oxidation of methane to carbon monoxide with liquid gallium-semiconductor composite

Autores: M. Nghe Tran, A. Skorynina, A. Addad, A. Fadel, K. Ben Tayeb, L. Karmazin, L. Thomas, M. Corda, Y. Wisse, O. Vovk, A.Y. Khodakov, B. Grandidier, V. Ordomsky
Publicado en: Applied Catalysis B: Environment and Energy, Edición 363, 2024, Página(s) 124834, ISSN 0926-3373
Editor: Elsevier BV
DOI: 10.1016/j.apcatb.2024.124834

Expression of concern: Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters

Autores: Alexandre Barras, Félix Sauvage, Inès de Hoon, Kevin Braeckmans, Dawei Hua, Gaëtan Buvat, Juan C. Fraire, Christophe Lethien, J. Sebag, Michael Harrington, Amar Abderrahmani, Rabah Boukherroub, Ste
Publicado en: Nanoscale Horizons, Edición 10, 2025, Página(s) 409-409, ISSN 2055-6756
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4nh90078b

Detection of 13 emerging soil pollutant compounds using a dual extraction method (QuEChERS and solid phase extraction) and a liquid chromatography/mass spectrometry LC-MS/MS method

Autores: Lara Maria Wakim, Amandine Descat, Florent Occelli, Annabelle Deram, Jean-François Goossens
Publicado en: MethodsX, Edición 12, 2025, Página(s) 102771, ISSN 2215-0161
Editor: Elsevier BV
DOI: 10.1016/j.mex.2024.102771

A Three-Step Process to Isolate Large Quantities of Bioactive Sesquiterpene Lactones from Cichorium intybus L. Roots and Semisynthesis of Chicory STLs Standards

Autores: Francesca Ruggieri, Philippe Hance, Bruna Gioia, Alexandre Biela, Pascal Roussel, Jean-Louis Hilbert, Nicolas Willand
Publicado en: Pharmaceuticals, Edición 16, 2025, Página(s) 771, ISSN 1424-8247
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph16050771

Thorough Validation of Optimized Size Exclusion Chromatography-Total Organic Carbon Analysis for Natural Organic Matter in Fresh Waters

Autores: Elien Laforce, Karlien Dejaeger, Marjolein Vanoppen, Emile Cornelissen, Jeriffa De Clercq, Pieter Vermeir
Publicado en: Molecules, Edición 29, 2025, Página(s) 2075, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules29092075

Boosting Gas-Phase TiO₂ Photocatalysis with Weak Electric Field Strengths of Volt/Centimeter

Autores: My Nghe Tran, Myriam Moreau, Ahmed Addad, Adrien Teurtrie, Thomas Roland, Vincent de Waele, Marc Dewitte, Louis Thomas, Gaëtan Levêque, Chunyang Dong, Pardis Simon, Karima Ben Tayeb, David Mele, Vit
Publicado en: ACS Applied Materials &amp; Interfaces, Edición 16, 2024, Página(s) 14852-14863, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.3c19031

Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase

Autores: Lucas Krawczyk, Shubham Semwal, Jalal Soubhye, Salma Lemri Ouadriri, Martin Prévost, Pierre Van Antwerpen, Goedele Roos, Julie Bouckaert
Publicado en: Acta Crystallographica Section D Structural Biology, Edición 78, 2025, Página(s) 1099-1109, ISSN 2059-7983
Editor: International Union of Crystallography (IUCr)
DOI: 10.1107/s2059798322007082

Antibiotics with novel mode of action as new weapons to fight antimicrobial resistance

Autores: Francesca Ruggieri, Nina Compagne, Kevin Antraygues, Maxime Eveque, Marion Flipo, Nicolas Willand
Publicado en: European Journal of Medicinal Chemistry, Edición 256, 2025, Página(s) 115413, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2023.115413

Mechanisms of DNA Damage Recognition by UDG and PARP1 in the Nucleosome

Autores: Safwen Ghediri, Parvathy A. P. Sarma, Vinnarasi Saravanan, Corinne Abbadie, Ralf Blossey, Fabrizio Cleri
Publicado en: Biomolecules, Edición 15, 2025, Página(s) 649, ISSN 2218-273X
Editor: MDPI AG
DOI: 10.3390/biom15050649

Exploration of the physical states of riboflavin (free base) by mechanical milling

Autores: C. Henaff, J. Siepmann, F. Siepmann, F. Danède, M.-N. Avettand-Fènoël, J. Vérin, A. Fadel, J.-F. Willart
Publicado en: International Journal of Pharmaceutics, Edición 645, 2025, Página(s) 123416, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2023.123416

Thesis and dissertations (3)

Tracing the O-GlcNAcylated proteins by the strategy of Amber suppression

Autores: Abou Anny, Christer
Publicado en: Thesis, Edición 2, 2024
Editor: Hal thèses

Formulation in the amorphous state : the cases of chlorhexidine and of riboflavin

Autores: Hénaff, Charline
Publicado en: Thesis, Edición 4, 2023
Editor: Hal Thèse

Environmental characterization of soils : new insights into the spatial variability of Crohn's disease?

Autores: Wakim, Lara Maria
Publicado en: Thesis, Edición 12, 2024
Editor: Hal thèses