Programme for EArly-stage Researchers in Lille

Informations projet

PEARL

N° de convention de subvention: 847568

DOI

10.3030/847568

Projet clôturé

Date de signature de la CE 20 Mai 2019

Date de début 9 Septembre 2019

Date de fin 8 Septembre 2025

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 4 881 600,00

Contribution de l’UE

€ 2 440 800,00

Coordonné par

UNIVERSITE DE LILLE
France

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (6)

Report on ethic issues for call 1

A short description on how the ethics procedure in place (as described in Annex I of the Grant Agreement) was followed and if relevant, the adaptations made. This part should also include a description of the role and composition of the ethics committee if such a committee was involved. An overview table based on the following structure (only for the successful fellows): name of the researcher; the title of research project with ethical issues; the ethics area(s) concerned; conditions to be fulfilled for funding and ethics requirements to be monitored during implementation; follow-up during the implementation. Only those research projects having ethics issues need to be detailed in this table.

Guidelines and forms for candidates & selection bodies
Final ethics report

The Final Ethics Report should summarise the ethics procedure followed during the entire project lifecycle and focus on the adaptation made and lessons learned. The report should also confirm that all required approvals/authorisations were obtained and that the research was conducted in compliance with the ethical principles and applicable international, EU and national law under H2020.

Report for call 1 on dissemination activities

Dates/Interval of call publication and dissemination channels/means (supporting documents are required as images, screen shots, photos from events). Flyers, brochures, or other information produced for dissemination of the call Presentations held at conferences and/or meetings and/or other events Articles published in the press (please list and attach only main articles) Any other means for advertising the programme

Report on ethic issues for call 2

A short description on how the ethics procedure in place (as described in Annex I of the Grant Agreement) was followed and if relevant, the adaptations made. This part should also include a description of the role and composition of the ethics committee if such a committee was involved. An overview table based on the following structure (only for the successful fellows): name of the researcher; the title of research project with ethical issues; the ethics area(s) concerned; conditions to be fulfilled for funding and ethics requirements to be monitored during implementation; follow-up during the implementation. Only those research projects having ethics issues need to be detailed in this table.

Report for call 2 on dissemination activities

Dates/Interval of call publication and dissemination channels/means (supporting documents are required as images, screen shots, photos from events). Flyers, brochures, or other information produced for dissemination of the call Presentations held at conferences and/or meetings and/or other events Articles published in the press (please list and attach only main articles) Any other means for advertising the programme

Websites, patent fillings, videos etc. (2)

Link to Euraxess website for call 2

Inform the Project Officer on publishing each call for proposals, by sending the link to the Euraxess website and a screen shot of the related call announcement.

Link to Euraxess website for Call 1

Inform the Project Officer on publishing each call for proposals, by sending the link to the Euraxess website and a screen shot of the related call announcement.

Publications

Peer reviewed articles (39)

Structure determination of riboflavin by synchrotron high-resolution powder X-ray diffraction

Auteurs: Mathieu Guerain, Frédéric Affouard, Charline Henaff, Catherine Dejoie, Florence Danède, Juergen Siepmann, Florence Siepmann, Jean-François Willart
Publié dans: Acta Crystallographica Section C Structural Chemistry, Numéro 77, 2025, Page(s) 800-806, ISSN 2053-2296
Éditeur: International Union of Crystallography (IUCr)
DOI: 10.1107/s2053229621012171

Wafer-Scale Performance Mapping of Magnetron-Sputtered Ternary Vanadium Tungsten Nitride for Microsupercapacitors

Auteurs: Khac Huy Dinh, Kevin Robert, Joelle Thuriot-Roukos, Marielle Huvé, Pardis Simon, David Troadec, Christophe Lethien, Pascal Roussel
Publié dans: Chemistry of Materials, Numéro 35, 2023, Page(s) 8654-8663, ISSN 0897-4756
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemmater.3c01803

Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins

Auteurs: Stefania Robakiewicz, Clarisse Bridot, Sonia Serna, Ana Gimeno, Begoña Echeverria, Sandra Delgado, Jérôme de Ruyck, Shubham Semwal, Diego Charro, Ann Dansercoer, Kenneth Verstraete, Mikel Azkargort
Publié dans: Glycobiology, Numéro 31, 2021, Page(s) 1005-1017, ISSN 1460-2423
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/glycob/cwab027

A Step‐by‐Step Guide for the Production of Recombinant Fluorescent TAT‐HA‐Tagged Proteins and their Transduction into Mammalian Cells

Auteurs: Christer Abou Anny, Sébastien Nouaille, Régis Fauré, Céline Schulz, Corentin Spriet, Isabelle Huvent, Christophe Biot, Tony Lefebvre
Publié dans: Current Protocols, Numéro 4, 2024, ISSN 2691-1299
Éditeur: Wiley
DOI: 10.1002/cpz1.1016

Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors

Auteurs: Eva-Maria Krammer, Clarisse Bridot, Sonia Serna, Begoña Echeverria, Shubham Semwal, Benoît Roubinet, Kim van Noort, Ruud H.P. Wilbers, Gleb Bourenkov, Jérôme de Ruyck, Ludovic Landemarre, Niels Re
Publié dans: Journal of Biological Chemistry, Numéro 299, 2025, Page(s) 104627, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2023.104627

Regioselective and Stereoselective Synthesis of Parthenolide Analogs by Acyl Nitroso-Ene Reaction and Their Biological Evaluation against Mycobacterium tuberculosis

Auteurs: Bruna Gioia, Francesca Ruggieri, Alexandre Biela, Valérie Landry, Pascal Roussel, Catherine Piveteau, Florence Leroux, Ruben C. Hartkoorn, Nicolas Willand
Publié dans: International Journal of Molecular Sciences, Numéro 24, 2025, Page(s) 17395, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242417395

The embedded research librarian: a project partner

Auteurs: Romain Féret, Marie Cros
Publié dans: LIBER Quarterly: The Journal of the Association of European Research Libraries, Numéro 29, 2022, Page(s) 1-20, ISSN 2213-056X
Éditeur: Ligue des Bibliotheques Europeennes de Recherche
DOI: 10.18352/lq.10304

<i>In Vitro</i> and <i>Ex Vivo</i> Models for Assessing Drug Permeation across the Cornea

Auteurs: Inès De Hoon, Rabah Boukherroub, Stefaan C. De Smedt, Sabine Szunerits, Félix Sauvage
Publié dans: Molecular Pharmaceutics, Numéro 20, 2023, Page(s) 3298-3319, ISSN 1543-8384
Éditeur: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.3c00195

Impact of Hot-Melt Extrusion on Glibenclamide’s Physical and Chemical States and Dissolution Behavior: Case Studies with Three Polymer Blend Matrices

Auteurs: Nina Zupan, Ines Yous, Florence Danede, Jeremy Verin, Mostafa Kouach, Catherine Foulon, Emeline Dudognon, Susanne Florin Muschert
Publié dans: Pharmaceutics, Numéro 16, 2025, Page(s) 1071, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16081071

Process-constrained batch Bayesian approaches for yield optimization in multi-reactor systems

Auteurs: Markus Grimm, Sébastien Paul, Pierre Chainais
Publié dans: Computers &amp; Chemical Engineering, Numéro 189, 2024, Page(s) 108779, ISSN 0098-1354
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.compchemeng.2024.108779

Small-angle X-ray scattering of engineered antigen-binding fragments: the case of glycosylated Fab from the Mannitou IgM antibody

Auteurs: Shubham Semwal, Maria Karamolegkou, Stéphanie Flament, Nessim Raouraoua, Kenneth Verstraete, Aurélien Thureau, Frank Wien, Fabrice Bray, Savvas N. Savvides, Julie Bouckaert
Publié dans: Acta Crystallographica Section F Structural Biology Communications, Numéro 81, 2025, Page(s) 19-29, ISSN 2053-230X
Éditeur: John Wiley and Sons Ltd
DOI: 10.1107/s2053230x24012159

Natural Antibodies: Protecting Role of IgM in Glioblastoma and Brain Tumours

Auteurs: Shubham Semwal, Rabah Boukherroub, Savvas N. Savvides, Julie Bouckaert
Publié dans: Current Pharmaceutical Design, Numéro 27, 2021, Page(s) 4515-4529, ISSN 1381-6128
Éditeur: Bentham Science Publishers
DOI: 10.2174/1381612827666210728103524

Advances on Microsupercapacitors: Real Fast Miniaturized Devices toward Technological Dreams for Powering Embedded Electronics?

Auteurs: Khac Huy Dinh, Pascal Roussel, Christophe Lethien
Publié dans: ACS Omega, Numéro 8, 2023, Page(s) 8977-8990, ISSN 2470-1343
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/acsomega.2c07549

Convolutional neural network application on a new middle Eocene radiolarian dataset

Auteurs: Veronica Carlsson, Taniel Danelian, Martin Tetard, Mathias Meunier, Pierre Boulet, Philippe Devienne, Sandra Ventalon
Publié dans: Marine Micropaleontology, Numéro 183, 2025, Page(s) 102268, ISSN 0377-8398
Éditeur: Elsevier BV
DOI: 10.1016/j.marmicro.2023.102268

Periodic membrane fractionation of freshwater organic matter reveals various reactivity patterns during chlorine/chloramine disinfection

Auteurs: Karlien Dejaeger, Marjolein Vanoppen, Justine Criquet, Gabriel Billon, Cécile Vignal, Emile R. Cornelissen
Publié dans: Separation and Purification Technology, Numéro 355, 2024, Page(s) 129635, ISSN 1383-5866
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.seppur.2024.129635

Biocatalytic Regioselective <i>O</i>‐acylation of Sesquiterpene Lactones from Chicory: A Pathway to Novel Ester Derivatives

Auteurs: J. Rodriguez Mosheim, F. Ruggieri, C. Humeau, P. Hance, N. Willand, J. L. Hilbert, E. Heuson, R. Froidevaux
Publié dans: ChemBioChem, Numéro 25, 2025, ISSN 1439-4227
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202300722

Artificial intelligence applied to the classification of eight middle Eocene species of the genus <i>Podocyrtis</i> (polycystine radiolaria)

Auteurs: Veronica Carlsson, Taniel Danelian, Pierre Boulet, Philippe Devienne, Aurelien Laforge, Johan Renaudie
Publié dans: Journal of Micropalaeontology, Numéro 41, 2022, Page(s) 165-182, ISSN 2041-4978
Éditeur: Copernicus GmbH
DOI: 10.5194/jm-41-165-2022

Metaproteomics identifies key cell wall degrading enzymes and proteins potentially related to inter-field variability in fiber quality during flax dew retting

Auteurs: S. Mukherjee, E. Goulas, A. Creach, F. Krzewinski, D. Galinousky, A.-S. Blervacq, P. D’Arras, S. Ratahiry, A. Menuge, D. Soulat, J.-M. Saliou, A.-S. Lacoste, S. Hawkins, S. Grec
Publié dans: Industrial Crops and Products, Numéro 222, 2024, Page(s) 119907, ISSN 0926-6690
Éditeur: Elsevier BV
DOI: 10.1016/j.indcrop.2024.119907

Morphometrics and machine learning discrimination of the middle Eocene radiolarian species Podocyrtis chalara, Podocyrtis goetheana and their morphological intermediates

Auteurs: Francisco Pinto, Veronica Carlsson, Mathias Meunier, Bert Van Bocxlaer, Hammouda Elbez, Marie Cueille, Pierre Boulet, Taniel Danelian
Publié dans: Marine Micropaleontology, Numéro 185, 2025, Page(s) 102293, ISSN 0377-8398
Éditeur: Elsevier BV
DOI: 10.1016/j.marmicro.2023.102293

Tracking flax dew retting by infrared vibrational spectroscopy combined with a powerful multivariate statistical analysis

Auteurs: Suvajit Mukherjee, Estelle Goulas, Isabelle De Waele, Anne Créach, Simon Hawkins, Sébastien Grec, Anne-Sophie Blervacq
Publié dans: Industrial Crops and Products, Numéro 227, 2025, Page(s) 120798, ISSN 0926-6690
Éditeur: Elsevier BV
DOI: 10.1016/j.indcrop.2025.120798

Sensorimotor Synchronization in Healthy Aging and Neurocognitive Disorders

Auteurs: Andres von Schnehen, Lise Hobeika, Dominique Huvent-Grelle, Séverine Samson
Publié dans: Frontiers in Psychology, Numéro 13, 2022, ISSN 1664-1078
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fpsyg.2022.838511

Sub-millielectronvolt Line Widths in Polarized Low-Temperature Photoluminescence of 2D PbS Nanoplatelets

Auteurs: Pengji Li, Leon Biesterfeld, Lars F. Klepzig, Jingzhong Yang, Huu Thoai Ngo, Ahmed Addad, Tom N. Rakow, Ruolin Guan, Eddy P. Rugeramigabo, Ivan Zaluzhnyy, Frank Schreiber, Louis Biadala, Jannika Lauth
Publié dans: Nano Letters, Numéro 24, 2025, Page(s) 16293-16300, ISSN 1530-6984
Éditeur: American Chemical Society
DOI: 10.1021/acs.nanolett.4c04402

PmForecast: leveraging temporal LSTM to deliver in situ air quality predictions

Auteurs: Maryam Rahmani, Suzanne Crumeyrolle, Nadége Allegri-Martiny, Amir Taherkordi, Romain Rouvoy
Publié dans: Environmental Science and Pollution Research, Numéro 31, 2024, Page(s) 51760-51773, ISSN 1614-7499
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s11356-024-34623-w

High Capacitance Porous Ruthenium Nitride Films with High Rate Capability for Micro‐Supercapacitors

Auteurs: Khac Huy Dinh, Grace Whang, Marielle Huve, David Troadec, Antoine Barnabé, Bruce Dunn, Pascal Roussel, Christophe Lethien
Publié dans: Small, 2024, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202402607

Unveiling the presence of endocrine disrupting chemicals in northern French soils: Land cover variability and implications

Auteurs: L.M. Wakim, F. Occelli, M. Paumelle, D. Brousmiche, L. Bouhadj, D. Cuny, A. Descat, C. Lanier, A. Deram
Publié dans: Science of The Total Environment, Numéro 913, 2024, Page(s) 169617, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.1016/j.scitotenv.2023.169617

Nanofeather ruthenium nitride electrodes for electrochemical capacitors

Auteurs: Huy Dinh Khac, Grace Whang, Antonella Iadecola, Houssine Makhlouf, Antoine Barnabé, Adrien Teurtrie, Maya Marinova, Marielle Huvé, Isabelle Roch-Jeune, Camille Douard, Thierry Brousse, Bruce Dunn, P
Publié dans: Nature Materials, Numéro 23, 2024, Page(s) 670-679, ISSN 1476-1122
Éditeur: Nature Publishing Group
DOI: 10.1038/s41563-024-01816-0

Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters

Auteurs: Alexandre Barras, Félix Sauvage, Inès de Hoon, Kevin Braeckmans, Dawei Hua, Gaëtan Buvat, Juan C. Fraire, Christophe Lethien, J. Sebag, Michael Harrington, Amar Abderrahmani, Rabah Boukherroub, Ste
Publié dans: Nanoscale Horizons, Numéro 6, 2024, Page(s) 449-461, ISSN 2055-6756
Éditeur: Royal Society of Chemistry (RSC)
DOI: 10.1039/d1nh00157d

Discovery of Anti-Coronavirus Cinnamoyl Triterpenoids Isolated from Hippophae rhamnoides during a Screening of Halophytes from the North Sea and Channel Coasts in Northern France

Auteurs: Malak Al Ibrahim, Zachee Louis Evariste Akissi, Lowiese Desmarets, Gabriel Lefèvre, Jennifer Samaillie, Imelda Raczkiewicz, Sevser Sahpaz, Jean Dubuisson, Sandrine Belouzard, Céline Rivière, Karin
Publié dans: International Journal of Molecular Sciences, Numéro 24, 2025, Page(s) 16617, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242316617

Mechanical and functional characterisation of a 3D porous biomimetic extracellular matrix to study insulin secretion from pancreatic β-cell lines

Auteurs: Leonid Pliner, Nathan Laneret, Meryl Roudaut, Alejandra Mogrovejo-Valdivia, Elodie Vandenhaute, Nathalie Maubon, Robert-Alain Toillon, Youness Karrout, Anthony Treizebre, Jean-Sébastien Annicotte
Publié dans: In vitro models, Numéro 3, 2024, Page(s) 205-218, ISSN 2731-3441
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s44164-024-00078-z

Electricity-driven selectivity in the photocatalytic oxidation of methane to carbon monoxide with liquid gallium-semiconductor composite

Auteurs: M. Nghe Tran, A. Skorynina, A. Addad, A. Fadel, K. Ben Tayeb, L. Karmazin, L. Thomas, M. Corda, Y. Wisse, O. Vovk, A.Y. Khodakov, B. Grandidier, V. Ordomsky
Publié dans: Applied Catalysis B: Environment and Energy, Numéro 363, 2024, Page(s) 124834, ISSN 0926-3373
Éditeur: Elsevier BV
DOI: 10.1016/j.apcatb.2024.124834

Expression of concern: Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters

Auteurs: Alexandre Barras, Félix Sauvage, Inès de Hoon, Kevin Braeckmans, Dawei Hua, Gaëtan Buvat, Juan C. Fraire, Christophe Lethien, J. Sebag, Michael Harrington, Amar Abderrahmani, Rabah Boukherroub, Ste
Publié dans: Nanoscale Horizons, Numéro 10, 2025, Page(s) 409-409, ISSN 2055-6756
Éditeur: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4nh90078b

Detection of 13 emerging soil pollutant compounds using a dual extraction method (QuEChERS and solid phase extraction) and a liquid chromatography/mass spectrometry LC-MS/MS method

Auteurs: Lara Maria Wakim, Amandine Descat, Florent Occelli, Annabelle Deram, Jean-François Goossens
Publié dans: MethodsX, Numéro 12, 2025, Page(s) 102771, ISSN 2215-0161
Éditeur: Elsevier BV
DOI: 10.1016/j.mex.2024.102771

A Three-Step Process to Isolate Large Quantities of Bioactive Sesquiterpene Lactones from Cichorium intybus L. Roots and Semisynthesis of Chicory STLs Standards

Auteurs: Francesca Ruggieri, Philippe Hance, Bruna Gioia, Alexandre Biela, Pascal Roussel, Jean-Louis Hilbert, Nicolas Willand
Publié dans: Pharmaceuticals, Numéro 16, 2025, Page(s) 771, ISSN 1424-8247
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph16050771

Thorough Validation of Optimized Size Exclusion Chromatography-Total Organic Carbon Analysis for Natural Organic Matter in Fresh Waters

Auteurs: Elien Laforce, Karlien Dejaeger, Marjolein Vanoppen, Emile Cornelissen, Jeriffa De Clercq, Pieter Vermeir
Publié dans: Molecules, Numéro 29, 2025, Page(s) 2075, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules29092075

Boosting Gas-Phase TiO₂ Photocatalysis with Weak Electric Field Strengths of Volt/Centimeter

Auteurs: My Nghe Tran, Myriam Moreau, Ahmed Addad, Adrien Teurtrie, Thomas Roland, Vincent de Waele, Marc Dewitte, Louis Thomas, Gaëtan Levêque, Chunyang Dong, Pardis Simon, Karima Ben Tayeb, David Mele, Vit
Publié dans: ACS Applied Materials &amp; Interfaces, Numéro 16, 2024, Page(s) 14852-14863, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.1021/acsami.3c19031

Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase

Auteurs: Lucas Krawczyk, Shubham Semwal, Jalal Soubhye, Salma Lemri Ouadriri, Martin Prévost, Pierre Van Antwerpen, Goedele Roos, Julie Bouckaert
Publié dans: Acta Crystallographica Section D Structural Biology, Numéro 78, 2025, Page(s) 1099-1109, ISSN 2059-7983
Éditeur: International Union of Crystallography (IUCr)
DOI: 10.1107/s2059798322007082

Antibiotics with novel mode of action as new weapons to fight antimicrobial resistance

Auteurs: Francesca Ruggieri, Nina Compagne, Kevin Antraygues, Maxime Eveque, Marion Flipo, Nicolas Willand
Publié dans: European Journal of Medicinal Chemistry, Numéro 256, 2025, Page(s) 115413, ISSN 0223-5234
Éditeur: Elsevier BV
DOI: 10.1016/j.ejmech.2023.115413

Mechanisms of DNA Damage Recognition by UDG and PARP1 in the Nucleosome

Auteurs: Safwen Ghediri, Parvathy A. P. Sarma, Vinnarasi Saravanan, Corinne Abbadie, Ralf Blossey, Fabrizio Cleri
Publié dans: Biomolecules, Numéro 15, 2025, Page(s) 649, ISSN 2218-273X
Éditeur: MDPI AG
DOI: 10.3390/biom15050649

Exploration of the physical states of riboflavin (free base) by mechanical milling

Auteurs: C. Henaff, J. Siepmann, F. Siepmann, F. Danède, M.-N. Avettand-Fènoël, J. Vérin, A. Fadel, J.-F. Willart
Publié dans: International Journal of Pharmaceutics, Numéro 645, 2025, Page(s) 123416, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2023.123416

Thesis and dissertations (3)

Tracing the O-GlcNAcylated proteins by the strategy of Amber suppression

Auteurs: Abou Anny, Christer
Publié dans: Thesis, Numéro 2, 2024
Éditeur: Hal thèses

Formulation in the amorphous state : the cases of chlorhexidine and of riboflavin

Auteurs: Hénaff, Charline
Publié dans: Thesis, Numéro 4, 2023
Éditeur: Hal Thèse

Environmental characterization of soils : new insights into the spatial variability of Crohn's disease?

Auteurs: Wakim, Lara Maria
Publié dans: Thesis, Numéro 12, 2024
Éditeur: Hal thèses