Programme for EArly-stage Researchers in Lille

Informazioni relative al progetto

PEARL

ID dell’accordo di sovvenzione: 847568

DOI

10.3030/847568

Progetto chiuso

Data della firma CE 20 Maggio 2019

Data di avvio 9 Settembre 2019

Data di completamento 8 Settembre 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 4 881 600,00

Contributo UE

€ 2 440 800,00

Coordinato da

UNIVERSITE DE LILLE
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (6)

Report on ethic issues for call 1

A short description on how the ethics procedure in place (as described in Annex I of the Grant Agreement) was followed and if relevant, the adaptations made. This part should also include a description of the role and composition of the ethics committee if such a committee was involved. An overview table based on the following structure (only for the successful fellows): name of the researcher; the title of research project with ethical issues; the ethics area(s) concerned; conditions to be fulfilled for funding and ethics requirements to be monitored during implementation; follow-up during the implementation. Only those research projects having ethics issues need to be detailed in this table.

Guidelines and forms for candidates & selection bodies
Final ethics report

The Final Ethics Report should summarise the ethics procedure followed during the entire project lifecycle and focus on the adaptation made and lessons learned. The report should also confirm that all required approvals/authorisations were obtained and that the research was conducted in compliance with the ethical principles and applicable international, EU and national law under H2020.

Report for call 1 on dissemination activities

Dates/Interval of call publication and dissemination channels/means (supporting documents are required as images, screen shots, photos from events). Flyers, brochures, or other information produced for dissemination of the call Presentations held at conferences and/or meetings and/or other events Articles published in the press (please list and attach only main articles) Any other means for advertising the programme

Report on ethic issues for call 2

A short description on how the ethics procedure in place (as described in Annex I of the Grant Agreement) was followed and if relevant, the adaptations made. This part should also include a description of the role and composition of the ethics committee if such a committee was involved. An overview table based on the following structure (only for the successful fellows): name of the researcher; the title of research project with ethical issues; the ethics area(s) concerned; conditions to be fulfilled for funding and ethics requirements to be monitored during implementation; follow-up during the implementation. Only those research projects having ethics issues need to be detailed in this table.

Report for call 2 on dissemination activities

Dates/Interval of call publication and dissemination channels/means (supporting documents are required as images, screen shots, photos from events). Flyers, brochures, or other information produced for dissemination of the call Presentations held at conferences and/or meetings and/or other events Articles published in the press (please list and attach only main articles) Any other means for advertising the programme

Websites, patent fillings, videos etc. (2)

Link to Euraxess website for call 2

Inform the Project Officer on publishing each call for proposals, by sending the link to the Euraxess website and a screen shot of the related call announcement.

Link to Euraxess website for Call 1

Inform the Project Officer on publishing each call for proposals, by sending the link to the Euraxess website and a screen shot of the related call announcement.

Pubblicazioni

Peer reviewed articles (39)

Structure determination of riboflavin by synchrotron high-resolution powder X-ray diffraction

Autori: Mathieu Guerain, Frédéric Affouard, Charline Henaff, Catherine Dejoie, Florence Danède, Juergen Siepmann, Florence Siepmann, Jean-François Willart
Pubblicato in: Acta Crystallographica Section C Structural Chemistry, Numero 77, 2025, Pagina/e 800-806, ISSN 2053-2296
Editore: International Union of Crystallography (IUCr)
DOI: 10.1107/s2053229621012171

Wafer-Scale Performance Mapping of Magnetron-Sputtered Ternary Vanadium Tungsten Nitride for Microsupercapacitors

Autori: Khac Huy Dinh, Kevin Robert, Joelle Thuriot-Roukos, Marielle Huvé, Pardis Simon, David Troadec, Christophe Lethien, Pascal Roussel
Pubblicato in: Chemistry of Materials, Numero 35, 2023, Pagina/e 8654-8663, ISSN 0897-4756
Editore: American Chemical Society
DOI: 10.1021/acs.chemmater.3c01803

Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins

Autori: Stefania Robakiewicz, Clarisse Bridot, Sonia Serna, Ana Gimeno, Begoña Echeverria, Sandra Delgado, Jérôme de Ruyck, Shubham Semwal, Diego Charro, Ann Dansercoer, Kenneth Verstraete, Mikel Azkargort
Pubblicato in: Glycobiology, Numero 31, 2021, Pagina/e 1005-1017, ISSN 1460-2423
Editore: Oxford University Press (OUP)
DOI: 10.1093/glycob/cwab027

A Step‐by‐Step Guide for the Production of Recombinant Fluorescent TAT‐HA‐Tagged Proteins and their Transduction into Mammalian Cells

Autori: Christer Abou Anny, Sébastien Nouaille, Régis Fauré, Céline Schulz, Corentin Spriet, Isabelle Huvent, Christophe Biot, Tony Lefebvre
Pubblicato in: Current Protocols, Numero 4, 2024, ISSN 2691-1299
Editore: Wiley
DOI: 10.1002/cpz1.1016

Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors

Autori: Eva-Maria Krammer, Clarisse Bridot, Sonia Serna, Begoña Echeverria, Shubham Semwal, Benoît Roubinet, Kim van Noort, Ruud H.P. Wilbers, Gleb Bourenkov, Jérôme de Ruyck, Ludovic Landemarre, Niels Re
Pubblicato in: Journal of Biological Chemistry, Numero 299, 2025, Pagina/e 104627, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2023.104627

Regioselective and Stereoselective Synthesis of Parthenolide Analogs by Acyl Nitroso-Ene Reaction and Their Biological Evaluation against Mycobacterium tuberculosis

Autori: Bruna Gioia, Francesca Ruggieri, Alexandre Biela, Valérie Landry, Pascal Roussel, Catherine Piveteau, Florence Leroux, Ruben C. Hartkoorn, Nicolas Willand
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2025, Pagina/e 17395, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242417395

The embedded research librarian: a project partner

Autori: Romain Féret, Marie Cros
Pubblicato in: LIBER Quarterly: The Journal of the Association of European Research Libraries, Numero 29, 2022, Pagina/e 1-20, ISSN 2213-056X
Editore: Ligue des Bibliotheques Europeennes de Recherche
DOI: 10.18352/lq.10304

<i>In Vitro</i> and <i>Ex Vivo</i> Models for Assessing Drug Permeation across the Cornea

Autori: Inès De Hoon, Rabah Boukherroub, Stefaan C. De Smedt, Sabine Szunerits, Félix Sauvage
Pubblicato in: Molecular Pharmaceutics, Numero 20, 2023, Pagina/e 3298-3319, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.3c00195

Impact of Hot-Melt Extrusion on Glibenclamide’s Physical and Chemical States and Dissolution Behavior: Case Studies with Three Polymer Blend Matrices

Autori: Nina Zupan, Ines Yous, Florence Danede, Jeremy Verin, Mostafa Kouach, Catherine Foulon, Emeline Dudognon, Susanne Florin Muschert
Pubblicato in: Pharmaceutics, Numero 16, 2025, Pagina/e 1071, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16081071

Process-constrained batch Bayesian approaches for yield optimization in multi-reactor systems

Autori: Markus Grimm, Sébastien Paul, Pierre Chainais
Pubblicato in: Computers &amp; Chemical Engineering, Numero 189, 2024, Pagina/e 108779, ISSN 0098-1354
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.compchemeng.2024.108779

Small-angle X-ray scattering of engineered antigen-binding fragments: the case of glycosylated Fab from the Mannitou IgM antibody

Autori: Shubham Semwal, Maria Karamolegkou, Stéphanie Flament, Nessim Raouraoua, Kenneth Verstraete, Aurélien Thureau, Frank Wien, Fabrice Bray, Savvas N. Savvides, Julie Bouckaert
Pubblicato in: Acta Crystallographica Section F Structural Biology Communications, Numero 81, 2025, Pagina/e 19-29, ISSN 2053-230X
Editore: John Wiley and Sons Ltd
DOI: 10.1107/s2053230x24012159

Natural Antibodies: Protecting Role of IgM in Glioblastoma and Brain Tumours

Autori: Shubham Semwal, Rabah Boukherroub, Savvas N. Savvides, Julie Bouckaert
Pubblicato in: Current Pharmaceutical Design, Numero 27, 2021, Pagina/e 4515-4529, ISSN 1381-6128
Editore: Bentham Science Publishers
DOI: 10.2174/1381612827666210728103524

Advances on Microsupercapacitors: Real Fast Miniaturized Devices toward Technological Dreams for Powering Embedded Electronics?

Autori: Khac Huy Dinh, Pascal Roussel, Christophe Lethien
Pubblicato in: ACS Omega, Numero 8, 2023, Pagina/e 8977-8990, ISSN 2470-1343
Editore: American Chemical Society (ACS)
DOI: 10.1021/acsomega.2c07549

Convolutional neural network application on a new middle Eocene radiolarian dataset

Autori: Veronica Carlsson, Taniel Danelian, Martin Tetard, Mathias Meunier, Pierre Boulet, Philippe Devienne, Sandra Ventalon
Pubblicato in: Marine Micropaleontology, Numero 183, 2025, Pagina/e 102268, ISSN 0377-8398
Editore: Elsevier BV
DOI: 10.1016/j.marmicro.2023.102268

Periodic membrane fractionation of freshwater organic matter reveals various reactivity patterns during chlorine/chloramine disinfection

Autori: Karlien Dejaeger, Marjolein Vanoppen, Justine Criquet, Gabriel Billon, Cécile Vignal, Emile R. Cornelissen
Pubblicato in: Separation and Purification Technology, Numero 355, 2024, Pagina/e 129635, ISSN 1383-5866
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.seppur.2024.129635

Biocatalytic Regioselective <i>O</i>‐acylation of Sesquiterpene Lactones from Chicory: A Pathway to Novel Ester Derivatives

Autori: J. Rodriguez Mosheim, F. Ruggieri, C. Humeau, P. Hance, N. Willand, J. L. Hilbert, E. Heuson, R. Froidevaux
Pubblicato in: ChemBioChem, Numero 25, 2025, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202300722

Artificial intelligence applied to the classification of eight middle Eocene species of the genus <i>Podocyrtis</i> (polycystine radiolaria)

Autori: Veronica Carlsson, Taniel Danelian, Pierre Boulet, Philippe Devienne, Aurelien Laforge, Johan Renaudie
Pubblicato in: Journal of Micropalaeontology, Numero 41, 2022, Pagina/e 165-182, ISSN 2041-4978
Editore: Copernicus GmbH
DOI: 10.5194/jm-41-165-2022

Metaproteomics identifies key cell wall degrading enzymes and proteins potentially related to inter-field variability in fiber quality during flax dew retting

Autori: S. Mukherjee, E. Goulas, A. Creach, F. Krzewinski, D. Galinousky, A.-S. Blervacq, P. D’Arras, S. Ratahiry, A. Menuge, D. Soulat, J.-M. Saliou, A.-S. Lacoste, S. Hawkins, S. Grec
Pubblicato in: Industrial Crops and Products, Numero 222, 2024, Pagina/e 119907, ISSN 0926-6690
Editore: Elsevier BV
DOI: 10.1016/j.indcrop.2024.119907

Morphometrics and machine learning discrimination of the middle Eocene radiolarian species Podocyrtis chalara, Podocyrtis goetheana and their morphological intermediates

Autori: Francisco Pinto, Veronica Carlsson, Mathias Meunier, Bert Van Bocxlaer, Hammouda Elbez, Marie Cueille, Pierre Boulet, Taniel Danelian
Pubblicato in: Marine Micropaleontology, Numero 185, 2025, Pagina/e 102293, ISSN 0377-8398
Editore: Elsevier BV
DOI: 10.1016/j.marmicro.2023.102293

Tracking flax dew retting by infrared vibrational spectroscopy combined with a powerful multivariate statistical analysis

Autori: Suvajit Mukherjee, Estelle Goulas, Isabelle De Waele, Anne Créach, Simon Hawkins, Sébastien Grec, Anne-Sophie Blervacq
Pubblicato in: Industrial Crops and Products, Numero 227, 2025, Pagina/e 120798, ISSN 0926-6690
Editore: Elsevier BV
DOI: 10.1016/j.indcrop.2025.120798

Sensorimotor Synchronization in Healthy Aging and Neurocognitive Disorders

Autori: Andres von Schnehen, Lise Hobeika, Dominique Huvent-Grelle, Séverine Samson
Pubblicato in: Frontiers in Psychology, Numero 13, 2022, ISSN 1664-1078
Editore: Frontiers Research Foundation
DOI: 10.3389/fpsyg.2022.838511

Sub-millielectronvolt Line Widths in Polarized Low-Temperature Photoluminescence of 2D PbS Nanoplatelets

Autori: Pengji Li, Leon Biesterfeld, Lars F. Klepzig, Jingzhong Yang, Huu Thoai Ngo, Ahmed Addad, Tom N. Rakow, Ruolin Guan, Eddy P. Rugeramigabo, Ivan Zaluzhnyy, Frank Schreiber, Louis Biadala, Jannika Lauth
Pubblicato in: Nano Letters, Numero 24, 2025, Pagina/e 16293-16300, ISSN 1530-6984
Editore: American Chemical Society
DOI: 10.1021/acs.nanolett.4c04402

PmForecast: leveraging temporal LSTM to deliver in situ air quality predictions

Autori: Maryam Rahmani, Suzanne Crumeyrolle, Nadége Allegri-Martiny, Amir Taherkordi, Romain Rouvoy
Pubblicato in: Environmental Science and Pollution Research, Numero 31, 2024, Pagina/e 51760-51773, ISSN 1614-7499
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s11356-024-34623-w

High Capacitance Porous Ruthenium Nitride Films with High Rate Capability for Micro‐Supercapacitors

Autori: Khac Huy Dinh, Grace Whang, Marielle Huve, David Troadec, Antoine Barnabé, Bruce Dunn, Pascal Roussel, Christophe Lethien
Pubblicato in: Small, 2024, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202402607

Unveiling the presence of endocrine disrupting chemicals in northern French soils: Land cover variability and implications

Autori: L.M. Wakim, F. Occelli, M. Paumelle, D. Brousmiche, L. Bouhadj, D. Cuny, A. Descat, C. Lanier, A. Deram
Pubblicato in: Science of The Total Environment, Numero 913, 2024, Pagina/e 169617, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/j.scitotenv.2023.169617

Nanofeather ruthenium nitride electrodes for electrochemical capacitors

Autori: Huy Dinh Khac, Grace Whang, Antonella Iadecola, Houssine Makhlouf, Antoine Barnabé, Adrien Teurtrie, Maya Marinova, Marielle Huvé, Isabelle Roch-Jeune, Camille Douard, Thierry Brousse, Bruce Dunn, P
Pubblicato in: Nature Materials, Numero 23, 2024, Pagina/e 670-679, ISSN 1476-1122
Editore: Nature Publishing Group
DOI: 10.1038/s41563-024-01816-0

Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters

Autori: Alexandre Barras, Félix Sauvage, Inès de Hoon, Kevin Braeckmans, Dawei Hua, Gaëtan Buvat, Juan C. Fraire, Christophe Lethien, J. Sebag, Michael Harrington, Amar Abderrahmani, Rabah Boukherroub, Ste
Pubblicato in: Nanoscale Horizons, Numero 6, 2024, Pagina/e 449-461, ISSN 2055-6756
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/d1nh00157d

Discovery of Anti-Coronavirus Cinnamoyl Triterpenoids Isolated from Hippophae rhamnoides during a Screening of Halophytes from the North Sea and Channel Coasts in Northern France

Autori: Malak Al Ibrahim, Zachee Louis Evariste Akissi, Lowiese Desmarets, Gabriel Lefèvre, Jennifer Samaillie, Imelda Raczkiewicz, Sevser Sahpaz, Jean Dubuisson, Sandrine Belouzard, Céline Rivière, Karin
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2025, Pagina/e 16617, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242316617

Mechanical and functional characterisation of a 3D porous biomimetic extracellular matrix to study insulin secretion from pancreatic β-cell lines

Autori: Leonid Pliner, Nathan Laneret, Meryl Roudaut, Alejandra Mogrovejo-Valdivia, Elodie Vandenhaute, Nathalie Maubon, Robert-Alain Toillon, Youness Karrout, Anthony Treizebre, Jean-Sébastien Annicotte
Pubblicato in: In vitro models, Numero 3, 2024, Pagina/e 205-218, ISSN 2731-3441
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s44164-024-00078-z

Electricity-driven selectivity in the photocatalytic oxidation of methane to carbon monoxide with liquid gallium-semiconductor composite

Autori: M. Nghe Tran, A. Skorynina, A. Addad, A. Fadel, K. Ben Tayeb, L. Karmazin, L. Thomas, M. Corda, Y. Wisse, O. Vovk, A.Y. Khodakov, B. Grandidier, V. Ordomsky
Pubblicato in: Applied Catalysis B: Environment and Energy, Numero 363, 2024, Pagina/e 124834, ISSN 0926-3373
Editore: Elsevier BV
DOI: 10.1016/j.apcatb.2024.124834

Expression of concern: Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters

Autori: Alexandre Barras, Félix Sauvage, Inès de Hoon, Kevin Braeckmans, Dawei Hua, Gaëtan Buvat, Juan C. Fraire, Christophe Lethien, J. Sebag, Michael Harrington, Amar Abderrahmani, Rabah Boukherroub, Ste
Pubblicato in: Nanoscale Horizons, Numero 10, 2025, Pagina/e 409-409, ISSN 2055-6756
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4nh90078b

Detection of 13 emerging soil pollutant compounds using a dual extraction method (QuEChERS and solid phase extraction) and a liquid chromatography/mass spectrometry LC-MS/MS method

Autori: Lara Maria Wakim, Amandine Descat, Florent Occelli, Annabelle Deram, Jean-François Goossens
Pubblicato in: MethodsX, Numero 12, 2025, Pagina/e 102771, ISSN 2215-0161
Editore: Elsevier BV
DOI: 10.1016/j.mex.2024.102771

A Three-Step Process to Isolate Large Quantities of Bioactive Sesquiterpene Lactones from Cichorium intybus L. Roots and Semisynthesis of Chicory STLs Standards

Autori: Francesca Ruggieri, Philippe Hance, Bruna Gioia, Alexandre Biela, Pascal Roussel, Jean-Louis Hilbert, Nicolas Willand
Pubblicato in: Pharmaceuticals, Numero 16, 2025, Pagina/e 771, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph16050771

Thorough Validation of Optimized Size Exclusion Chromatography-Total Organic Carbon Analysis for Natural Organic Matter in Fresh Waters

Autori: Elien Laforce, Karlien Dejaeger, Marjolein Vanoppen, Emile Cornelissen, Jeriffa De Clercq, Pieter Vermeir
Pubblicato in: Molecules, Numero 29, 2025, Pagina/e 2075, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules29092075

Boosting Gas-Phase TiO₂ Photocatalysis with Weak Electric Field Strengths of Volt/Centimeter

Autori: My Nghe Tran, Myriam Moreau, Ahmed Addad, Adrien Teurtrie, Thomas Roland, Vincent de Waele, Marc Dewitte, Louis Thomas, Gaëtan Levêque, Chunyang Dong, Pardis Simon, Karima Ben Tayeb, David Mele, Vit
Pubblicato in: ACS Applied Materials &amp; Interfaces, Numero 16, 2024, Pagina/e 14852-14863, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.3c19031

Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase

Autori: Lucas Krawczyk, Shubham Semwal, Jalal Soubhye, Salma Lemri Ouadriri, Martin Prévost, Pierre Van Antwerpen, Goedele Roos, Julie Bouckaert
Pubblicato in: Acta Crystallographica Section D Structural Biology, Numero 78, 2025, Pagina/e 1099-1109, ISSN 2059-7983
Editore: International Union of Crystallography (IUCr)
DOI: 10.1107/s2059798322007082

Antibiotics with novel mode of action as new weapons to fight antimicrobial resistance

Autori: Francesca Ruggieri, Nina Compagne, Kevin Antraygues, Maxime Eveque, Marion Flipo, Nicolas Willand
Pubblicato in: European Journal of Medicinal Chemistry, Numero 256, 2025, Pagina/e 115413, ISSN 0223-5234
Editore: Elsevier BV
DOI: 10.1016/j.ejmech.2023.115413

Mechanisms of DNA Damage Recognition by UDG and PARP1 in the Nucleosome

Autori: Safwen Ghediri, Parvathy A. P. Sarma, Vinnarasi Saravanan, Corinne Abbadie, Ralf Blossey, Fabrizio Cleri
Pubblicato in: Biomolecules, Numero 15, 2025, Pagina/e 649, ISSN 2218-273X
Editore: MDPI AG
DOI: 10.3390/biom15050649

Exploration of the physical states of riboflavin (free base) by mechanical milling

Autori: C. Henaff, J. Siepmann, F. Siepmann, F. Danède, M.-N. Avettand-Fènoël, J. Vérin, A. Fadel, J.-F. Willart
Pubblicato in: International Journal of Pharmaceutics, Numero 645, 2025, Pagina/e 123416, ISSN 0378-5173
Editore: Elsevier BV
DOI: 10.1016/j.ijpharm.2023.123416

Thesis and dissertations (3)

Tracing the O-GlcNAcylated proteins by the strategy of Amber suppression

Autori: Abou Anny, Christer
Pubblicato in: Thesis, Numero 2, 2024
Editore: Hal thèses

Formulation in the amorphous state : the cases of chlorhexidine and of riboflavin

Autori: Hénaff, Charline
Pubblicato in: Thesis, Numero 4, 2023
Editore: Hal Thèse

Environmental characterization of soils : new insights into the spatial variability of Crohn's disease?

Autori: Wakim, Lara Maria
Pubblicato in: Thesis, Numero 12, 2024
Editore: Hal thèses