Host-targeted Approaches for the Prevention and the treatment of Hospital-Acquired Pneumonia

Project Information

HAP2

Grant agreement ID: 847782

DOI

10.3030/847782

EC signature date 5 December 2019

Start date 1 January 2020

End date 31 December 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 9 996 350,25

EU contribution

€ 9 996 350,25

Coordinated by

CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
France

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

Project Exploitation, Dissemination and Communication plan

Websites, patent fillings, videos etc. (1)

Project website

Publications

Peer reviewed articles (13)

Monocyte Signature Associated with Herpes Simplex Virus Reactivation and Neurological Recovery after Brain Injury

Author(s): Tanguy Chaumette, Raphael Cinotti, Alice Mollé, Pierre Solomon, Louise Castain, Cynthia Fourgeux, Hamish E. G. McWilliam, Barbara Misme-Aucouturier, Alexis Broquet, Cédric Jacqueline, Mickael Vourc’h, Delphine Fradin, Celine Bossard, Laurent David, Emmanuel Montassier, Cecile Braudeau, Régis Josien, Jose A. Villadangos, Karim Asehnoune, Celine Bressollette-Bodin, Jeremie Poschmann, and Antoin
Published in: American Journal of Respiratory and Critical Care Medicine, Issue 1073449X, 2022, Page(s) 295-310, ISSN 1073-449X
Publisher: American Thoracic Society
DOI: 10.1164/rccm.202110-2324oc

Dexamethasone attenuates interferon-related cytokine hyperresponsiveness in COVID-19 patients

Author(s): Job J. Engel, Caspar I. van der Made, Nick Keur, Todia Setiabudiawan, Rutger J. Röring, Georgia Damoraki, Helga Dijkstra, Heidi Lemmers, Sofia Ioannou, Garyfallia Poulakou, Jos W. M. van der Meer, Evangelos J. Giamarellos-Bourboulis, Vinod Kumar, Frank L. van de Veerdonk, Mihai G. Netea, Athanasios Ziogas
Published in: Frontiers in Immunology, Issue 14, 2023, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2023.1233318

GM-CSF: Master regulator of the T cell-phagocyte interface during inflammation

Author(s): Florian Ingelfinger; Donatella De Feo; Burkhard Becher
Published in: Seminars in Immunology, Issue 1, 2021, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.5167/uzh-209328

Robust airway microbiome signatures in acute respiratory failure and hospital-acquired pneumonia

Author(s): Emmanuel Montassier, Georgios D. Kitsios, Josiah E. Radder, Quentin Le Bastard, Brendan J. Kelly, Ariane Panzer, Susan V. Lynch, Carolyn S. Calfee, Robert P. Dickson, Antoine Roquilly
Published in: Nature Medicine, Issue 29, 2023, Page(s) 2793-2804, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-023-02617-9

Interferon gamma-1b for the prevention of hospital-acquired pneumonia in critically ill patients: a phase 2, placebo-controlled randomized clinical trial

Author(s): Antoine Roquilly, Bruno Francois, Olivier Huet, Yoann Launey, Sigismond Lasocki, Emmanuel Weiss, Melanie Petrier, Yannick Hourmant, Marwan Bouras, Karim Lakhal, Cecilia Le Bel, Delphine Flattres Duchaussoy, Laia Fernández-Barat, Adrian Ceccato, Laurent Flet, Alexandra Jobert, Jeremie Poschmann, Veronique Sebille, Fanny Feuillet, Despoina Koulenti, Antoni Torres on behalf of the Atlanrea study gro
Published in: Intensive Care Medicine, 2023, ISSN 0342-4642
Publisher: Springer Verlag
DOI: 10.1007/s00134-023-07065-0

How to Investigate the Effects of Groups on Changes in Longitudinal Patient-Reported Outcomes and Response Shift Using Rasch Models

Author(s): Karima Hammas, Véronique Sébille, Priscilla Brisson, Jean-Benoit Hardouin, Myriam Blanchin
Published in: Frontiers in Psychology, Issue 11, 2020, ISSN 1664-1078
Publisher: Frontiers Research Foundation
DOI: 10.3389/fpsyg.2020.613482

Spatiotemporal Adaptations of Macrophage and Dendritic Cell Development and Function

Author(s): Antoine Roquilly, Justine D. Mintern, and Jose A. Villadangos
Published in: Annual Review of Immunology, Issue Volume 40, 2022, ISSN 1545-3278
Publisher: Annual Reviews
DOI: 10.1146/annurev-immunol-101320-031931

Association of Dynamics of Anellovirus Loads With Hospital-Acquired Pneumonia in Patients With Brain Injury During the Intensive Care Unit Stay

Author(s): Louise Castain, Mélanie Petrier, Simon Bulteau, Cécile Peltier, Cécile Poulain, Marwan Bouras, Berthe-Marie Imbert-Marcille, Jérémie Poschmann, Antoine Roquilly, Céline Bressollette-Bodin
Published in: The Journal of Infectious Diseases, 2024, ISSN 0022-1899
Publisher: University of Chicago Press
DOI: 10.1093/infdis/jiae110

Value of a secretomic approach for distinguishing patients with COVID‐19 viral pneumonia among patients with respiratory distress admitted to intensive care unit

Author(s): Angélique Blangy‐Letheule, Amandine Vergnaud, Thomas Dupas, Damien Habert, Jérôme Montnach, Walid Oulehri, Dorian Hassoun, Manon Denis, Jules Lecomte, Antoine Persello, Antoine Roquilly, José Courty, Michel Seve, Aurélia A. Leroux, Bertrand Rozec, Sandrine Bourgoin‐Voillard, Michel De Waard, Benjamin Lauzier
Published in: Journal of Medical Virology, Issue 96, 2024, ISSN 0146-6615
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29756

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia

Author(s): Stefanie Kreutmair, Susanne Unger, Nicolás Gonzalo Núñez, Florian Ingelfinger, Chiara Alberti, Donatella De Feo, Sinduya Krishnarajah, Manuel Kauffmann, Ekaterina Friebel, Sepideh Babaei, Benjamin Gaborit, Mirjam Lutz, Nicole Puertas Jurado, Nisar P. Malek, Siri Goepel, Peter Rosenberger, Helene A. Häberle, Ikram Ayoub, Sally Al-Hajj, Jakob Nilsson, Manfred Classen, Roland Liblau, Guillaume Ma
Published in: Immunity, 2021, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.05.002

Performance of a Rasch-based method for group comparisons of longitudinal change and response shift at the item level in PRO data: A simulation study

Author(s): Myriam Blanchin, Priscilla Brisson, Véronique Sébille
Published in: Methods, 2022, ISSN 1046-2023
Publisher: Academic Press
DOI: 10.1016/j.ymeth.2022.01.002

Preexisting comorbidities shape the immune response associated with severe COVID-19

Author(s): Stefanie Kreutmair, Manuel Kauffmann, Susanne Unger, Florian Ingelfinger, Nicolás Gonzalo Núñez, Chiara Alberti, Donatella De Feo, Sinduya Krishnarajah, Ekaterina Friebel, Can Ulutekin, Sepideh Babaei, Benjamin Gaborit, Mirjam Lutz, Nicole Puertas Jurado, Nisar P Malek, Siri Göpel, Peter Rosenberger, Helene A Häberle, Ikram Ayoub, Sally Al-Hajj, Manfred Claassen, Roland Liblau, Guillaume Mart
Published in: Journal of Allergy and Clinical Immunology, Issue 00916749, 2022, Page(s) 312-324, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2022.05.019

Intestinal microbe-derived metabolites instruct macrophages in the lungs

Author(s): Antoine Roquilly; Jose A. Villadangos
Published in: Nature Immmunology, 2022, Page(s) pages1662–1664, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-022-01358-0