Host-targeted Approaches for the Prevention and the treatment of Hospital-Acquired Pneumonia

Informazioni relative al progetto

HAP2

ID dell’accordo di sovvenzione: 847782

DOI

10.3030/847782

Data della firma CE 5 Dicembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 31 Dicembre 2026

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 9 996 350,25

Contributo UE

€ 9 996 350,25

Coordinato da

CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (1)

Project Exploitation, Dissemination and Communication plan

Websites, patent fillings, videos etc. (1)

Project website

Pubblicazioni

Peer reviewed articles (21)

Monocyte Signature Associated with Herpes Simplex Virus Reactivation and Neurological Recovery after Brain Injury

Autori: Tanguy Chaumette, Raphael Cinotti, Alice Mollé, Pierre Solomon, Louise Castain, Cynthia Fourgeux, Hamish E. G. McWilliam, Barbara Misme-Aucouturier, Alexis Broquet, Cédric Jacqueline, Mickael Vourc’h, Delphine Fradin, Celine Bossard, Laurent David, Emmanuel Montassier, Cecile Braudeau, Régis Josien, Jose A. Villadangos, Karim Asehnoune, Celine Bressollette-Bodin, Jeremie Poschmann, and Antoin
Pubblicato in: American Journal of Respiratory and Critical Care Medicine, Numero 2022 Aug 1;206(3):295-310, 2022, Pagina/e 295-310, ISSN 1073-449X
Editore: American Thoracic Society
DOI: 10.1164/rccm.202110-2324oc

Dexamethasone attenuates interferon-related cytokine hyperresponsiveness in COVID-19 patients

Autori: Job J. Engel, Caspar I. van der Made, Nick Keur, Todia Setiabudiawan, Rutger J. Röring, Georgia Damoraki, Helga Dijkstra, Heidi Lemmers, Sofia Ioannou, Garyfallia Poulakou, Jos W. M. van der Meer, Evangelos J. Giamarellos-Bourboulis, Vinod Kumar, Frank L. van de Veerdonk, Mihai G. Netea, Athanasios Ziogas
Pubblicato in: Frontiers in Immunology, Numero 14, 2023, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2023.1233318

Metagenome-assembled complete genome of <i>Bohxovirus</i> , a virulent bacteriophage involved in the prediction of hospital-acquired pneumonia in intubated critically ill patients

Autori: Hussein Anani, Grégory Destras, Hadrien Regue, Simon Bulteau, Céline Bressollette-Bodin, Antoine Roquilly, Laurence Josset
Pubblicato in: Microbiology Resource Announcements, Numero 14, 2025, ISSN 2576-098X
Editore: American Society for Microbiology
DOI: 10.1128/mra.00592-25

GM-CSF: Master regulator of the T cell-phagocyte interface during inflammation

Autori: Florian Ingelfinger; Donatella De Feo; Burkhard Becher
Pubblicato in: Seminars in Immunology, Numero 1, 2021, ISSN 1044-5323
Editore: Academic Press
DOI: 10.5167/uzh-209328

Robust airway microbiome signatures in acute respiratory failure and hospital-acquired pneumonia

Autori: Emmanuel Montassier, Georgios D. Kitsios, Josiah E. Radder, Quentin Le Bastard, Brendan J. Kelly, Ariane Panzer, Susan V. Lynch, Carolyn S. Calfee, Robert P. Dickson, Antoine Roquilly
Pubblicato in: Nature Medicine, Numero 29, 2023, Pagina/e 2793-2804, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-023-02617-9

Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients

Autori: Hussein Anani, Grégory Destras, Simon Bulteau, Louise Castain, Quentin Semanas, Gwendolyne Burfin, Mélanie Petrier, Florian P. Martin, Cecile Poulain, Robert P. Dickson, Céline Bressollette-Bodin, Antoine Roquilly, Laurence Josset
Pubblicato in: Cell Reports Medicine, Numero 6, 2025, Pagina/e 102289, ISSN 2666-3791
Editore: Elsevier BV
DOI: 10.1016/j.xcrm.2025.102289

Interferon gamma-1b for the prevention of hospital-acquired pneumonia in critically ill patients: a phase 2, placebo-controlled randomized clinical trial

Autori: Antoine Roquilly, Bruno Francois, Olivier Huet, Yoann Launey, Sigismond Lasocki, Emmanuel Weiss, Melanie Petrier, Yannick Hourmant, Marwan Bouras, Karim Lakhal, Cecilia Le Bel, Delphine Flattres Duchaussoy, Laia Fernández-Barat, Adrian Ceccato, Laurent Flet, Alexandra Jobert, Jeremie Poschmann, Veronique Sebille, Fanny Feuillet, Despoina Koulenti, Antoni Torres on behalf of the Atlanrea study gro
Pubblicato in: Intensive Care Medicine, 2023, ISSN 0342-4642
Editore: Springer Verlag
DOI: 10.1007/s00134-023-07065-0

Glucocorticoid Treatment for Hospital-Acquired and Ventilator-Associated Pneumonia

Autori: Cécile Poulain, Marwan Bouras, Antoine Roquilly
Pubblicato in: Seminars in Respiratory and Critical Care Medicine, Numero 47, 2026, Pagina/e 077-085, ISSN 1069-3424
Editore: Thieme Medical Publishers
DOI: 10.1055/a-2694-4781

How to Investigate the Effects of Groups on Changes in Longitudinal Patient-Reported Outcomes and Response Shift Using Rasch Models

Autori: Karima Hammas, Véronique Sébille, Priscilla Brisson, Jean-Benoit Hardouin, Myriam Blanchin
Pubblicato in: Frontiers in Psychology, Numero 11, 2020, ISSN 1664-1078
Editore: Frontiers Research Foundation
DOI: 10.3389/fpsyg.2020.613482

Spatiotemporal Adaptations of Macrophage and Dendritic Cell Development and Function

Autori: Antoine Roquilly, Justine D. Mintern, and Jose A. Villadangos
Pubblicato in: Annual Review of Immunology, Numero Volume 40, 2022, ISSN 1545-3278
Editore: Annual Reviews
DOI: 10.1146/annurev-immunol-101320-031931

Identification and validation of robust hospital-acquired pneumonia subphenotypes associated with all-cause mortality: a multi-cohort derivation and validation

Autori: Florian Pierre Martin, Cécile Poulain, Jelle Haitsma Mulier, Ana Motos, Victor Gourain, Ismaël Ogan, Emmanuel Montassier, Yoann Launey, Sigismond Lasocki, Raphaël Cinotti, Claire Dahyot Fizelier, Otavio Ranzani, Luis Felipe Reyes, Ignacio Martin-Loeches, Lennie Derde, Antoni Torres, Olaf Cremer, Antoine Roquilly
Pubblicato in: Intensive Care Medicine, Numero 51, 2025, Pagina/e 692-707, ISSN 0342-4642
Editore: Springer Verlag
DOI: 10.1007/s00134-025-07884-3

Three-month outcomes and cost-effectiveness of interferon gamma-1b in critically ill patients: a secondary analysis of the PREV-HAP trial

Autori: Marwan Bouras, Philippe Tessier, Cécile Poulain, Solène Schirr-Bonnans, Antoine Roquilly
Pubblicato in: Journal of Intensive Care, Numero 12, 2024, ISSN 2052-0492
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s40560-024-00753-z

Association of Dynamics of Anellovirus Loads With Hospital-Acquired Pneumonia in Patients With Brain Injury During the Intensive Care Unit Stay

Autori: Louise Castain, Mélanie Petrier, Simon Bulteau, Cécile Peltier, Cécile Poulain, Marwan Bouras, Berthe-Marie Imbert-Marcille, Jérémie Poschmann, Antoine Roquilly, Céline Bressollette-Bodin
Pubblicato in: The Journal of Infectious Diseases, 2024, ISSN 0022-1899
Editore: University of Chicago Press
DOI: 10.1093/infdis/jiae110

Value of a secretomic approach for distinguishing patients with COVID‐19 viral pneumonia among patients with respiratory distress admitted to intensive care unit

Autori: Angélique Blangy‐Letheule, Amandine Vergnaud, Thomas Dupas, Damien Habert, Jérôme Montnach, Walid Oulehri, Dorian Hassoun, Manon Denis, Jules Lecomte, Antoine Persello, Antoine Roquilly, José Courty, Michel Seve, Aurélia A. Leroux, Bertrand Rozec, Sandrine Bourgoin‐Voillard, Michel De Waard, Benjamin Lauzier
Pubblicato in: Journal of Medical Virology, Numero 96, 2024, ISSN 0146-6615
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29756

Reconsidering ventilator-associated pneumonia from a new dimension of the lung microbiome

Autori: Laia Fernández-Barat, Ruben López-Aladid, Antoni Torres
Pubblicato in: EBioMedicine, Numero 60, 2025, Pagina/e 102995, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2020.102995

Alveolar Macrophages: Adaptation to Their Anatomic Niche during and after Inflammation

Autori: Florian Pierre Martin, Cédric Jacqueline, Jeremie Poschmann, Antoine Roquilly
Pubblicato in: Cells, Numero 10, 2025, Pagina/e 2720, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/cells10102720

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia

Autori: Stefanie Kreutmair, Susanne Unger, Nicolás Gonzalo Núñez, Florian Ingelfinger, Chiara Alberti, Donatella De Feo, Sinduya Krishnarajah, Manuel Kauffmann, Ekaterina Friebel, Sepideh Babaei, Benjamin Gaborit, Mirjam Lutz, Nicole Puertas Jurado, Nisar P. Malek, Siri Goepel, Peter Rosenberger, Helene A. Häberle, Ikram Ayoub, Sally Al-Hajj, Jakob Nilsson, Manfred Classen, Roland Liblau, Guillaume Ma
Pubblicato in: Immunity, 2021, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2021.05.002

Performance of a Rasch-based method for group comparisons of longitudinal change and response shift at the item level in PRO data: A simulation study

Autori: Myriam Blanchin, Priscilla Brisson, Véronique Sébille
Pubblicato in: Methods, 2022, ISSN 1046-2023
Editore: Academic Press
DOI: 10.1016/j.ymeth.2022.01.002

Preexisting comorbidities shape the immune response associated with severe COVID-19

Autori: Stefanie Kreutmair, Manuel Kauffmann, Susanne Unger, Florian Ingelfinger, Nicolás Gonzalo Núñez, Chiara Alberti, Donatella De Feo, Sinduya Krishnarajah, Ekaterina Friebel, Can Ulutekin, Sepideh Bab
Pubblicato in: Journal of Allergy and Clinical Immunology, Numero Volume 150, Numero 2, August 2022, 2022, Pagina/e 312-324, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2022.05.019

Pathophysiology and clinical applications of PEEP in acute brain injury

Autori: Ida Giorgia Iavarone, Patricia Rieken Macedo Rocco, Domenico Luca Grieco, Tommaso Rosà, Mariangela Pellegrini, Rafael Badenes, Robert D. Stevens, Karim Asehnoune, Chiara Robba, Luigi Camporota, Antoine Roquilly
Pubblicato in: Intensive Care Medicine, Numero 51, 2025, Pagina/e 2104-2116, ISSN 0342-4642
Editore: Springer Verlag
DOI: 10.1007/s00134-025-08111-9

Intestinal microbe-derived metabolites instruct macrophages in the lungs

Autori: Antoine Roquilly; Jose A. Villadangos
Pubblicato in: Nature Immmunology, 2022, Pagina/e pages1662–1664, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-022-01358-0