Host-targeted Approaches for the Prevention and the treatment of Hospital-Acquired Pneumonia

Información del proyecto

HAP2

Identificador del acuerdo de subvención: 847782

DOI

10.3030/847782

Fecha de la firma de la CE 5 Diciembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Diciembre 2026

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 9 996 350,25

Aportación de la UE

€ 9 996 350,25

Coordinado por

CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (1)

Project Exploitation, Dissemination and Communication plan

Websites, patent fillings, videos etc. (1)

Project website

Publicaciones

Peer reviewed articles (21)

Monocyte Signature Associated with Herpes Simplex Virus Reactivation and Neurological Recovery after Brain Injury

Autores: Tanguy Chaumette, Raphael Cinotti, Alice Mollé, Pierre Solomon, Louise Castain, Cynthia Fourgeux, Hamish E. G. McWilliam, Barbara Misme-Aucouturier, Alexis Broquet, Cédric Jacqueline, Mickael Vourc’h, Delphine Fradin, Celine Bossard, Laurent David, Emmanuel Montassier, Cecile Braudeau, Régis Josien, Jose A. Villadangos, Karim Asehnoune, Celine Bressollette-Bodin, Jeremie Poschmann, and Antoin
Publicado en: American Journal of Respiratory and Critical Care Medicine, Edición 2022 Aug 1;206(3):295-310, 2022, Página(s) 295-310, ISSN 1073-449X
Editor: American Thoracic Society
DOI: 10.1164/rccm.202110-2324oc

Dexamethasone attenuates interferon-related cytokine hyperresponsiveness in COVID-19 patients

Autores: Job J. Engel, Caspar I. van der Made, Nick Keur, Todia Setiabudiawan, Rutger J. Röring, Georgia Damoraki, Helga Dijkstra, Heidi Lemmers, Sofia Ioannou, Garyfallia Poulakou, Jos W. M. van der Meer, Evangelos J. Giamarellos-Bourboulis, Vinod Kumar, Frank L. van de Veerdonk, Mihai G. Netea, Athanasios Ziogas
Publicado en: Frontiers in Immunology, Edición 14, 2023, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2023.1233318

Metagenome-assembled complete genome of <i>Bohxovirus</i> , a virulent bacteriophage involved in the prediction of hospital-acquired pneumonia in intubated critically ill patients

Autores: Hussein Anani, Grégory Destras, Hadrien Regue, Simon Bulteau, Céline Bressollette-Bodin, Antoine Roquilly, Laurence Josset
Publicado en: Microbiology Resource Announcements, Edición 14, 2025, ISSN 2576-098X
Editor: American Society for Microbiology
DOI: 10.1128/mra.00592-25

GM-CSF: Master regulator of the T cell-phagocyte interface during inflammation

Autores: Florian Ingelfinger; Donatella De Feo; Burkhard Becher
Publicado en: Seminars in Immunology, Edición 1, 2021, ISSN 1044-5323
Editor: Academic Press
DOI: 10.5167/uzh-209328

Robust airway microbiome signatures in acute respiratory failure and hospital-acquired pneumonia

Autores: Emmanuel Montassier, Georgios D. Kitsios, Josiah E. Radder, Quentin Le Bastard, Brendan J. Kelly, Ariane Panzer, Susan V. Lynch, Carolyn S. Calfee, Robert P. Dickson, Antoine Roquilly
Publicado en: Nature Medicine, Edición 29, 2023, Página(s) 2793-2804, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-023-02617-9

Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients

Autores: Hussein Anani, Grégory Destras, Simon Bulteau, Louise Castain, Quentin Semanas, Gwendolyne Burfin, Mélanie Petrier, Florian P. Martin, Cecile Poulain, Robert P. Dickson, Céline Bressollette-Bodin, Antoine Roquilly, Laurence Josset
Publicado en: Cell Reports Medicine, Edición 6, 2025, Página(s) 102289, ISSN 2666-3791
Editor: Elsevier BV
DOI: 10.1016/j.xcrm.2025.102289

Interferon gamma-1b for the prevention of hospital-acquired pneumonia in critically ill patients: a phase 2, placebo-controlled randomized clinical trial

Autores: Antoine Roquilly, Bruno Francois, Olivier Huet, Yoann Launey, Sigismond Lasocki, Emmanuel Weiss, Melanie Petrier, Yannick Hourmant, Marwan Bouras, Karim Lakhal, Cecilia Le Bel, Delphine Flattres Duchaussoy, Laia Fernández-Barat, Adrian Ceccato, Laurent Flet, Alexandra Jobert, Jeremie Poschmann, Veronique Sebille, Fanny Feuillet, Despoina Koulenti, Antoni Torres on behalf of the Atlanrea study gro
Publicado en: Intensive Care Medicine, 2023, ISSN 0342-4642
Editor: Springer Verlag
DOI: 10.1007/s00134-023-07065-0

Glucocorticoid Treatment for Hospital-Acquired and Ventilator-Associated Pneumonia

Autores: Cécile Poulain, Marwan Bouras, Antoine Roquilly
Publicado en: Seminars in Respiratory and Critical Care Medicine, Edición 47, 2026, Página(s) 077-085, ISSN 1069-3424
Editor: Thieme Medical Publishers
DOI: 10.1055/a-2694-4781

How to Investigate the Effects of Groups on Changes in Longitudinal Patient-Reported Outcomes and Response Shift Using Rasch Models

Autores: Karima Hammas, Véronique Sébille, Priscilla Brisson, Jean-Benoit Hardouin, Myriam Blanchin
Publicado en: Frontiers in Psychology, Edición 11, 2020, ISSN 1664-1078
Editor: Frontiers Research Foundation
DOI: 10.3389/fpsyg.2020.613482

Spatiotemporal Adaptations of Macrophage and Dendritic Cell Development and Function

Autores: Antoine Roquilly, Justine D. Mintern, and Jose A. Villadangos
Publicado en: Annual Review of Immunology, Edición Volume 40, 2022, ISSN 1545-3278
Editor: Annual Reviews
DOI: 10.1146/annurev-immunol-101320-031931

Identification and validation of robust hospital-acquired pneumonia subphenotypes associated with all-cause mortality: a multi-cohort derivation and validation

Autores: Florian Pierre Martin, Cécile Poulain, Jelle Haitsma Mulier, Ana Motos, Victor Gourain, Ismaël Ogan, Emmanuel Montassier, Yoann Launey, Sigismond Lasocki, Raphaël Cinotti, Claire Dahyot Fizelier, Otavio Ranzani, Luis Felipe Reyes, Ignacio Martin-Loeches, Lennie Derde, Antoni Torres, Olaf Cremer, Antoine Roquilly
Publicado en: Intensive Care Medicine, Edición 51, 2025, Página(s) 692-707, ISSN 0342-4642
Editor: Springer Verlag
DOI: 10.1007/s00134-025-07884-3

Three-month outcomes and cost-effectiveness of interferon gamma-1b in critically ill patients: a secondary analysis of the PREV-HAP trial

Autores: Marwan Bouras, Philippe Tessier, Cécile Poulain, Solène Schirr-Bonnans, Antoine Roquilly
Publicado en: Journal of Intensive Care, Edición 12, 2024, ISSN 2052-0492
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s40560-024-00753-z

Association of Dynamics of Anellovirus Loads With Hospital-Acquired Pneumonia in Patients With Brain Injury During the Intensive Care Unit Stay

Autores: Louise Castain, Mélanie Petrier, Simon Bulteau, Cécile Peltier, Cécile Poulain, Marwan Bouras, Berthe-Marie Imbert-Marcille, Jérémie Poschmann, Antoine Roquilly, Céline Bressollette-Bodin
Publicado en: The Journal of Infectious Diseases, 2024, ISSN 0022-1899
Editor: University of Chicago Press
DOI: 10.1093/infdis/jiae110

Value of a secretomic approach for distinguishing patients with COVID‐19 viral pneumonia among patients with respiratory distress admitted to intensive care unit

Autores: Angélique Blangy‐Letheule, Amandine Vergnaud, Thomas Dupas, Damien Habert, Jérôme Montnach, Walid Oulehri, Dorian Hassoun, Manon Denis, Jules Lecomte, Antoine Persello, Antoine Roquilly, José Courty, Michel Seve, Aurélia A. Leroux, Bertrand Rozec, Sandrine Bourgoin‐Voillard, Michel De Waard, Benjamin Lauzier
Publicado en: Journal of Medical Virology, Edición 96, 2024, ISSN 0146-6615
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29756

Reconsidering ventilator-associated pneumonia from a new dimension of the lung microbiome

Autores: Laia Fernández-Barat, Ruben López-Aladid, Antoni Torres
Publicado en: EBioMedicine, Edición 60, 2025, Página(s) 102995, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2020.102995

Alveolar Macrophages: Adaptation to Their Anatomic Niche during and after Inflammation

Autores: Florian Pierre Martin, Cédric Jacqueline, Jeremie Poschmann, Antoine Roquilly
Publicado en: Cells, Edición 10, 2025, Página(s) 2720, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/cells10102720

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia

Autores: Stefanie Kreutmair, Susanne Unger, Nicolás Gonzalo Núñez, Florian Ingelfinger, Chiara Alberti, Donatella De Feo, Sinduya Krishnarajah, Manuel Kauffmann, Ekaterina Friebel, Sepideh Babaei, Benjamin Gaborit, Mirjam Lutz, Nicole Puertas Jurado, Nisar P. Malek, Siri Goepel, Peter Rosenberger, Helene A. Häberle, Ikram Ayoub, Sally Al-Hajj, Jakob Nilsson, Manfred Classen, Roland Liblau, Guillaume Ma
Publicado en: Immunity, 2021, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2021.05.002

Performance of a Rasch-based method for group comparisons of longitudinal change and response shift at the item level in PRO data: A simulation study

Autores: Myriam Blanchin, Priscilla Brisson, Véronique Sébille
Publicado en: Methods, 2022, ISSN 1046-2023
Editor: Academic Press
DOI: 10.1016/j.ymeth.2022.01.002

Preexisting comorbidities shape the immune response associated with severe COVID-19

Autores: Stefanie Kreutmair, Manuel Kauffmann, Susanne Unger, Florian Ingelfinger, Nicolás Gonzalo Núñez, Chiara Alberti, Donatella De Feo, Sinduya Krishnarajah, Ekaterina Friebel, Can Ulutekin, Sepideh Bab
Publicado en: Journal of Allergy and Clinical Immunology, Edición Volume 150, Edición 2, August 2022, 2022, Página(s) 312-324, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2022.05.019

Pathophysiology and clinical applications of PEEP in acute brain injury

Autores: Ida Giorgia Iavarone, Patricia Rieken Macedo Rocco, Domenico Luca Grieco, Tommaso Rosà, Mariangela Pellegrini, Rafael Badenes, Robert D. Stevens, Karim Asehnoune, Chiara Robba, Luigi Camporota, Antoine Roquilly
Publicado en: Intensive Care Medicine, Edición 51, 2025, Página(s) 2104-2116, ISSN 0342-4642
Editor: Springer Verlag
DOI: 10.1007/s00134-025-08111-9

Intestinal microbe-derived metabolites instruct macrophages in the lungs

Autores: Antoine Roquilly; Jose A. Villadangos
Publicado en: Nature Immmunology, 2022, Página(s) pages1662–1664, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-022-01358-0