Comorbid Analysis of Neurodevelopmental Disorders and Epilepsy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Report on developmental trajectories in PTCHD1 genetic mouse model

Report on developmental trajectories of co-morbidity phenotype expression in PTCHD1 genetic mouse model

Report on prototype of tablet based translational test battery for pre-schoolers

Prototype of tablet based translational test battery for pre-schoolers

Report on developmental trajectories in NRNX1 and SHANK3 genetic mouse models

Report on developmental trajectories of comorbidity phenotype expression in NRNX1 and SHANK3 genetic mouse models

Communication toolbox
Report on the critical developmental windows for treatment intervention

Report on the critical developmental windows for treatment intervention based on the expression of pathogenic pathways.

First collection of training materials
Internet-based discussion forum set up

Internetbased discussion forum set up

CANDY public website and social media channels

Publications

Autistic and nonautistic adolescents do not differ in adaptation to gaze direction

Author(s): Emma K. Ward, Jan K. Buitelaar, Sabine Hunnius
Published in: Autism Research, Issue 17, 2024, Page(s) 1001-1015, ISSN 1939-3806
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/aur.3118

Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms.

Author(s): Joanna Szopinska-Tokov; Sarita Dam; Jilly Naaijen; Prokopis Konstanti; Nanda Rommelse; Clara Belzer; Jan Buitelaar; Barbara Franke; Mirjam Bloemendaal; Esther Aarts; Alejandro Arias Vasquez
Published in: Microorganisms, Issue 3, 2020, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/microorganisms8030406

Cerebellar atypicalities in autism?

Author(s): Charles Laidi; Dorothea L. Floris; Julian Tillmann; Yannis Elandaloussi; Mariam Zabihi; Tony Charman; Thomas Wolfers; Sarah Durston; Carolin Moessnang; Flavio Dell’Acqua; Christine Ecker; Eva Loth; Declan Murphy; Simon Baron-Cohen; Jan K. Buitelaar; Andre F. Marquand; Christian F. Beckmann; Vincent Frouin; Marion Leboyer; Edouard Duchesnay; Pierrick Coupé; Josselin Houenou; null Tobias Banasche
Published in: Biological Psychiatry, 92, 674 - 682, Issue 3, 2022, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2022.05.020

Global motion processing in infants’ visual cortex and the emergence of autism

Author(s): Irzam Hardiansyah, Pär Nyström, Mark J. Taylor, Sven Bölte, Angelica Ronald, Terje Falck-Ytter
Published in: Communications Biology, Issue 6, 2023, ISSN 2399-3642
Publisher: Nature Portfolio
DOI: 10.1038/s42003-023-04707-3

Disrupted extracellular matrix and cell cycle genes in autism-associated Shank3 deficiency are targeted by lithium

Author(s): Valentin Ioannidis, Rakshita Pandey, Helen Friedericke Bauer, Michael Schön, Jürgen Bockmann, Tobias M. Boeckers, Anne-Kathrin Lutz
Published in: Molecular Psychiatry, Issue 29, 2024, Page(s) 704-717, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-023-02362-y

Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research

Author(s): Na Cai, Brad Verhulst, Ole A. Andreassen, Jan Buitelaar, Howard J. Edenberg, John M. Hettema, Michael Gandal, Andrew Grotzinger, Katherine Jonas, Phil Lee, Travis T. Mallard, Manuel Mattheisen, Michael C. Neale, John I. Nurnberger, Wouter J. Peyrot, Elliot M. Tucker-Drob, Jordan W. Smoller, Kenneth S. Kendler
Published in: Molecular Psychiatry, Issue 30, 2025, Page(s) 1627-1638, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-024-02878-x

Suppression of Cofilin function in the somatosensory cortex alters social contact behavior in the BTBR mouse inbred line

Author(s): Iris W Riemersma, Kevin G O Ike, Thomas Sollie, Elroy L Meijer, Robbert Havekes, Martien J H Kas
Published in: Cerebral Cortex, Issue 34, 2024, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhae136

SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system

Author(s): Mariagiovanna Malara; Anne-Kathrin Lutz; Berra Incearap; Helen Friedericke Bauer; Silvia Cursano; Katrin Volbracht; Joanna Janina Lerner; Rakshita Pandey; Jan Philipp Delling; Valentin Ioannidis; Andrea Pérez Arévalo; Jaime Eugenin von Bernhardi; Michael Schön; Jürgen Bockmann; Leda Dimou; Tobias M. Boeckers
Published in: Cell Mol Life Sci, Issue 3, 2022, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-022-04400-4

Coordinated Cortical Thickness Alterations Across Six Neurodevelopmental and Psychiatric Disorders

Author(s): Hettwer MD, Larivière S, Park BY, van den Heuvel OA, Schmaal L, Andreassen OA, Ching CRK, Hoogman M, Buitelaar J, van Rooij D, Veltman DJ, Stein DJ, Franke B, van Erp TGM; ENIGMA ADHD Working Group; ENIGMA Autism Working Group; ENIGMA Bipolar Disorder Working Group; ENIGMA Major Depression Working Group; ENIGMA OCD Working Group; ENIGMA Schizophrenia Working Group; Jahanshad N, Thompson PM, Thomo
Published in: Nat Commun, Issue 2022 Nov 11;13(1), 2022, Page(s) 6851, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34367-6

Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis

Author(s): Maja Rudling, Pär Nyström, Sven Bölte, Terje Falck‐Ytter
Published in: Journal of Child Psychology and Psychiatry, 2021, ISSN 0021-9630
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.13520

Evaluation of data imputation strategies in complex, deeply-phenotyped data sets: the case of the EU-AIMS Longitudinal European Autism Project.

Author(s): Llera, A; Brammer, M; Oakley, B; Tillmann, J; Zabihi, M; Amelink, J S; Mei, T; Charman, T; Ecker, C; Dell'Acqua, F; Banaschewski, T; Moessnang, C; Baron-Cohen, S; Holt, R; Durston, S; Murphy, D; Loth, E; Buitelaar, J K; Floris, D L; Beckmann, C F
Published in: BMC Med Res Methodol, Issue 3, 2022, ISSN 1471-2288
Publisher: BioMed Central
DOI: 10.1186/s12874-022-01656-z

Spatial and Temporal Gene Function Studies in Rodents: Towards Gene-Based Therapies for Autism Spectrum Disorder

Author(s): Riemersma IW, Havekes R, Kas MJH
Published in: Genes, Issue 2021 Dec 23;13(1), 2021, Page(s) 28, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13010028

Infant responses to direct gaze and associations to autism: A live eye-tracking study

Author(s): Maja Rudling, Pär Nyström, Giorgia Bussu, Sven Bölte, Terje Falck-Ytter
Published in: Autism, Issue 28, 2024, Page(s) 1677-1689, ISSN 1362-3613
Publisher: SAGE Publications
DOI: 10.1177/13623613231203037

Age-related brain deviations and aggression

Author(s): Holz NE, Floris DL, Llera A, Aggensteiner PM, Kia SM, Wolfers T, Baumeister S, Böttinger B, Glennon JC, Hoekstra PJ, Dietrich A, Saam MC, Schulze UME, Lythgoe DJ, Williams SCR, Santosh P, Rosa-Justicia M, Bargallo N, Castro-Fornieles J, Arango C, Penzol MJ, Walitza S, Meyer-Lindenberg A, Zwiers M, Franke B, Buitelaar J, Naaijen J, Brandeis D, Beckmann C, Banaschewski T, Marquand AF.
Published in: Psychol Med, Issue 2022 Apr 22, 2022, Page(s) 1-10, ISSN 0033-2917
Publisher: Cambridge University Press
DOI: 10.1017/s003329172200068x

Neurobiological Correlates of Change in Adaptive Behavior in Autism

Author(s): Pretzsch CM, Schäfer T, Lombardo MV, Warrier V, Mann C, Bletsch A, Chatham CH, Floris DL, Tillmann J, Yousaf A, Jones E, […] Beckmann CF, Banaschewski T, Durston S, Freitag CM; EU-AIMS LEAP Group; Murphy DGM, Ecker C..
Published in: Am J Psychiatry, Issue 2022 May;179(5), 2022, Page(s) 336-349, ISSN 0002-953X
Publisher: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.21070711

What are you looking at? Gaze following with and without target objects in ASD and typical development.

Author(s): Thorup E, Nyström P, Bölte S, Falck-Ytter T
Published in: Autism, Issue 2022 Oct;26(7), 2022, Page(s) 1668-1680, ISSN 1362-3613
Publisher: SAGE Publications
DOI: 10.1177/13623613211061940

Gray matter covariations in autism: out-of-sample replication using the ENIGMA autism cohort

Author(s): Ting Mei, Alberto Llera, Natalie J. Forde, Daan van Rooij, Dorothea L. Floris, Christian F. Beckmann, Jan K. Buitelaar
Published in: Molecular Autism, Issue 15, 2024, ISSN 2040-2392
Publisher: BioMed Central
DOI: 10.1186/s13229-024-00583-8

Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review

Author(s): Tamouza R, Volt F, Richard JR, Wu CL, Bouassida J, Boukouaci W, Lansiaux P, Cappelli B, Scigliuolo GM, Rafii H, Kenzey C, Mezouad E, Naamoune S, Chami L, Lejuste F, Farge D, Gluckman E
Published in: Front Cell Dev Biol., Issue 2022 Jul 5;10, 2022, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fcell.2022.809686

From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans.

Author(s): Ahmad J, Ellis C, Leech R, Voytek B, Garces P, Jones E, Buitelaar J, Loth E, Dos Santos FP, Amil AF, Verschure PFMJ, Murphy D, McAlonan G
Published in: Transl Psychiatry., Issue 2022 Nov 8;12(1):, 2022, Page(s) 467, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-022-02218-z

Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology

Author(s): Mei T, Forde NJ, Floris DL, Dell'Acqua F, Stones R, Ilioska I, Durston S, Moessnang C, Banaschewski T, Holt RJ, Baron-Cohen S, Rausch A, Loth E, Oakley B, Charman T, Ecker C, Murphy DGM; EU-AIMS LEAP group; Beckmann CF, Llera A, Buitelaar JK.
Published in: Biol Psychiatry Cogn Neurosci Neuroimaging, Issue 2022 Sep 6:S2451-9022(22), 2022, Page(s) 00212-9, ISSN 2451-9022
Publisher: Elsevier Inc. Al
DOI: 10.1016/j.bpsc.2022.08.011

Expression profiles of the autism-related SHANK proteins in the human brain

Author(s): Sarah Woelfle, Maria T. Pedro, Jan Wagner, Michael Schön, Tobias M. Boeckers
Published in: BMC Biology, Issue 21, 2023, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-023-01712-0

Large‐scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents

Author(s): F. Kurth, D. Schijven, O. A. van den Heuvel, M. Hoogman, D. van Rooij, D. J. Stein, J. K. Buitelaar, S. Bölte, G. Auzias, A. Kushki, G. Venkatasubramanian, K. Rubia, S. Bollmann, J. Isaksson, F. Jaspers‐Fayer, R. Marsh, M. C. Batistuzzo, P. D. Arnold, R. A. Bressan, S. E. Stewart, P. Gruner, L. Sorensen, P. M. Pan, T. J. Silk, R. C. Gur, A. I. Cubillo, J. Haavik, R. L. O'Gorman Tuura, C. A. Har
Published in: Human Brain Mapping, Issue 45, 2025, ISSN 1065-9471
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hbm.26754

Brain‐age prediction: Systematic evaluation of site effects, and sample age range and size

Author(s): Yuetong Yu, Hao‐Qi Cui, Shalaila S. Haas, Faye New, Nicole Sanford, Kevin Yu, Denghuang Zhan, Guoyuan Yang, Jia‐Hong Gao, Dongtao Wei, Jiang Qiu, Nerisa Banaj, Dorret I. Boomsma, Alan Breier, Henry Brodaty, Randy L. Buckner, Jan K. Buitelaar, Dara M. Cannon, Xavier Caseras, Vincent P. Clark, Patricia J. Conrod, Fabrice Crivello, Eveline A. Crone, Udo Dannlowski, Christopher G. Davey, Lieuwe de
Published in: Human Brain Mapping, Issue 45, 2024, ISSN 1065-9471
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hbm.26768

SHANK3 Antibody Validation: Differential Performance in Western Blotting, Immunocyto- and Immunohistochemistry.

Author(s): Anne-Kathrin Lutz; Helen Friedericke Bauer; Valentin Ioannidis; Michael Schön; Tobias M. Boeckers
Published in: Front Synaptic Neurosci ., Issue 3, 2022, ISSN 1663-3563
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnsyn.2022.890231

The breakdown of social looking

Author(s): Terje Falck-Ytter
Published in: Neuroscience & Biobehavioral Reviews, Issue 161, 2024, Page(s) 105689, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2024.105689

Development of sex- and genotype-specific behavioral phenotypes in a Shank3 mouse model for neurodevelopmental disorders

Author(s): Helen Friedericke Bauer, Jan Philipp Delling, Jürgen Bockmann, Tobias M. Boeckers, Michael Schön
Published in: Frontiers in Behavioral Neuroscience, Issue 16, 2023, ISSN 1662-5153
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2022.1051175

Phenotypic effects of genetic variants associated with autism

Author(s): Thomas Rolland, Freddy Cliquet, Richard J. L. Anney, Clara Moreau, Nicolas Traut, Alexandre Mathieu, Guillaume Huguet, Jinjie Duan, Varun Warrier, Swan Portalier, Louise Dry, Claire S. Leblond, Elise Douard, Frédérique Amsellem, Simon Malesys, Anna Maruani, Roberto Toro, Anders D. Børglum, Jakob Grove, Simon Baron-Cohen, Alan Packer, Wendy K. Chung, Sébastien Jacquemont, Richard Delorme, Thoma
Published in: Nature Medicine, Issue 29, 2023, Page(s) 1671-1680, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-023-02408-2

Author(s): Berra Yildiz, Lisa Schiedt, Medhanie Mulaw, Jürgen Bockmann, Sarah Jesse, Anne-Kathrin Lutz, Tobias M. Boeckers
Published in: Frontiers in Cell and Developmental Biology, Issue 11, 2023, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2023.1243299

Patterns of connectome variability in autism across five functional activation tasks: findings from the LEAP project

Author(s): Looden T, Floris DL, Llera A, Chauvin RJ, Charman T, Banaschewski T, Murphy D, Marquand AF, Buitelaar JK, Beckmann CF; AIMS-2-TRIALS group
Published in: Mol Autism, Issue 2022 Dec 27;13(1), 2022, Page(s) 53, ISSN 2040-2392
Publisher: BioMed Central
DOI: 10.1186/s13229-022-00529

Cross-sectional and longitudinal neuroanatomical profiles of distinct clinical (adaptive) outcomes in autism

Author(s): Charlotte M. Pretzsch, Dorothea L. Floris, Tim Schäfer, Anke Bletsch, Caroline Gurr, Michael V. Lombardo, Chris H. Chatham, Julian Tillmann, Tony Charman, Martina Arenella, Emily Jones, Sara Ambrosino, Thomas Bourgeron, Guillaume Dumas, Freddy Cliquet, Claire S. Leblond, Eva Loth, Bethany Oakley, Jan K. Buitelaar, Simon Baron-Cohen, Christian F. Beckmann, Antonio M. Persico, Tobias Banaschewski,
Published in: Molecular Psychiatry, Issue 28, 2023, Page(s) 2158-2169, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-023-02016-z

A multimodal neural signature of face processing in autism within the fusiform gyrus

Author(s): Dorothea L. Floris, Alberto Llera, Mariam Zabihi, Carolin Moessnang, Emily J. H. Jones, Luke Mason, Rianne Haartsen, Nathalie E. Holz, Ting Mei, Camille Elleaume, Bruno Hebling Vieira, Charlotte M. Pretzsch, Natalie J. Forde, Sarah Baumeister, Flavio Dell’Acqua, Sarah Durston, Tobias Banaschewski, Christine Ecker, Rosemary J. Holt, Simon Baron-Cohen, Thomas Bourgeron, Tony Charman, Eva Loth, Dec
Published in: Nature Mental Health, Issue 3, 2025, Page(s) 31-45, ISSN 2731-6076
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44220-024-00349-4

Qualitative differences in the spatiotemporal brain states supporting configural face processing emerge in adolescence in autism

Author(s): Haartsen R, Mason L, Garces P, Gui A, Charman T, Tillmann J, Johnson MH, Buitelaar JK, Loth E, Murphy D, Jones EJH; EU-AIMS LEAP group.
Published in: Cortex, Issue 2022 Oct;155, 2022, Page(s) 13-29, ISSN 0010-9452
Publisher: Masson Publishing
DOI: 10.1016/j.cortex.2022.06.010

Local Molecular and Global Connectomic Contributions to Cross-Disorder Cortical Abnormalities

Author(s): Hansen JY, Shafiei G, Vogel JW, Smart K, Bearden CE, Hoogman M, Franke B, van Rooij D, Buitelaar J, McDonald CR, Sisodiya SM, Schmaal L, Veltman DJ, van den Heuvel OA, Stein DJ, van Erp TGM, Ching CRK, Andreassen OA, Hajek T, Opel N, Modinos G, Aleman A, van der Werf Y, Jahanshad N, Thomopoulos SI, Thompson PM, Carson RE, Dagher A, Misic B.
Published in: Nat Commun, Issue 2022 Aug 10;13(1):, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32420-y

Pre‐pragmatic language use in toddlerhood: Developmental antecedents, aetiological factors, and associations to autism

Author(s): Maja Rudling, Ana Maria Portugal, Sven Bölte, Terje Falck‐Ytter
Published in: JCPP Advances, Issue 3, 2023, ISSN 2692-9384
Publisher: Wiley-Blackwell
DOI: 10.1002/jcv2.12135

Does the current state of biomarker discovery in autism reflect the limits of reductionism in precision medicine? Suggestions for an integrative approach that considers dynamic mechanisms between brain, body, and the social environment

Author(s): Eva Loth
Published in: Frontiers in Psychiatry, Issue 14, 2023, ISSN 1664-0640
Publisher: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2023.1085445

Attention-deficit/hyperactivity disorder

Author(s): Stephen V. Faraone, Mark A. Bellgrove, Isabell Brikell, Samuele Cortese, Catharina A. Hartman, Chris Hollis, Jeffrey H. Newcorn, Alexandra Philipsen, Guilherme V. Polanczyk, Katya Rubia, Margaret H. Sibley, Jan K. Buitelaar
Published in: Nature Reviews Disease Primers, Issue 10, 2024, ISSN 2056-676X
Publisher: Nature Portfolio
DOI: 10.1038/s41572-024-00495-0

SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(−/−) Mice

Author(s): Lutz, Anne-Kathrin; Pérez Arévalo, Andrea; Ioannidis, Valentin; Stirmlinger, Nadine; Demestre, Maria; Delorme, Richard; Bourgeron, Thomas; Boeckers, Tobias M.
Published in: Frontiers in Molecular Neuroscience, Issue 3, 2021, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.18725/oparu-40117

Less frequent face looking in infancy is related to autism likelihood status but not diagnosis: A study of parent-infant interaction

Author(s): Emilia Thorup, Sven Bölte, Terje Falck-Ytter
Published in: Research in Autism Spectrum Disorders, Issue 115, 2024, Page(s) 102422, ISSN 1750-9467
Publisher: Elsevier BV
DOI: 10.1016/j.rasd.2024.102422

Tracing the paths: a systematic review of mediators of complex trauma and complex post-traumatic stress disorder

Author(s): Joseph Harris, Eva Loth, Vaheshta Sethna
Published in: Frontiers in Psychiatry, Issue 15, 2024, ISSN 1664-0640
Publisher: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2024.1331256

How 18-month-olds with Later Autism Look at Other Children Interacting: The Timing of Gaze Allocation

Author(s): Charlotte Viktorsson, Sven Bölte, Terje Falck-Ytter
Published in: Journal of Autism and Developmental Disorders, 2023, ISSN 0162-3257
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10803-023-06118-z

Structural models of genome-wide covariance identify multiple common dimensions in autism

Author(s): Lucía de Hoyos, Maria T. Barendse, Fenja Schlag, Marjolein M. J. van Donkelaar, Ellen Verhoef, Chin Yang Shapland, Alexander Klassmann, Jan Buitelaar, Brad Verhulst, Simon E. Fisher, Dheeraj Rai, Beate St Pourcain
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-46128-8

Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications

Author(s): Delling JP, Boeckers TM
Published in: J Neurodev Disord, Issue 2021 Nov 16;13(1), 2021, Page(s) 55, ISSN 1866-1955
Publisher: Springer Nature
DOI: 10.1186/s11689-021-09397-8

Decomposing the Brain in Autism: Linking Behavioral Domains to Neuroanatomical Variation and Genomic Underpinnings

Author(s): Hanna Seelemeyer, Caroline Gurr, Johanna Leyhausen, Lisa M. Berg, Charlotte M. Pretzsch, Tim Schäfer, Bassem Hermila, Christine M. Freitag, Eva Loth, Bethany Oakley, Luke Mason, Jan K. Buitelaar, Christian F. Beckmann, Dorothea L. Floris, Tony Charman, Tobias Banaschewski, Emily Jones, Thomas Bourgeron, Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Tobias Banaschewski, Simon Baron-Cohen, Sarah Ba
Published in: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2025, ISSN 2451-9022
Publisher: Elsevier BV
DOI: 10.1016/j.bpsc.2024.12.003

Deletion of the Autism-Associated Protein SHANK3 Abolishes Structural Synaptic Plasticity after Brain Trauma.

Author(s): Urrutia-Ruiz, Carolina; Rombach, Daniel; Cursano, Silvia; Gerlach-Arbeiter, Susanne; Schoen, Michael; Bockmann, Juergen; Demestre, Maria; Boeckers, Tobias M.; Pérez-Mediavilla, Alberto
Published in: International Journal of Molecular Sciences; Volume 23; Issue 11; Pages: 6081, Issue 3, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23116081

Low-grade inflammation as mediator between diet and behavioral disinhibition: A UK Biobank study.

Author(s): Shi H, Schweren LJS, Ter Horst R, Bloemendaal M, van Rooij D, Vasquez AA, Hartman CA, Buitelaar JK
Published in: Brain Behav Immun, Issue 2022 Nov;106, 2022, Page(s) 100-110., ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2022.07.165

Connectome-wide Mega-analysis Reveals Robust Patterns of Atypical Functional Connectivity in Autism

Author(s): Iva Ilioska, Marianne Oldehinkel, Alberto Llera, Sidhant Chopra, Tristan Looden, Roselyne Chauvin, Daan Van Rooij, Dorothea L. Floris, Julian Tillmann, Carolin Moessnang, Tobias Banaschewski, Rosemary J. Holt, Eva Loth, Tony Charman, Declan G.M. Murphy, Christine Ecker, Maarten Mennes, Christian F. Beckmann, Alex Fornito, Jan K. Buitelaar
Published in: Biological Psychiatry, Issue 94, 2023, Page(s) 29-39, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2022.12.018

The future of child and adolescent clinical psychopharmacology: A systematic review of phase 2, 3, or 4 randomized controlled trials of pharmacologic agents without regulatory approval or for unapproved indications

Author(s): Samuele Cortese, Katherine McGinn, Mikkel Højlund, Alan Apter, Celso Arango, Immaculada Baeza, Tobias Banaschewski, Jan Buitelaar, Josefina Castro-Fornieles, David Coghill, David Cohen, Edna Grünblatt, Pieter J. Hoekstra, Anthony James, Pia Jeppesen, Péter Nagy, Anne Katrine Pagsberg, Mara Parellada, Antonio M. Persico, Diane Purper-Ouakil, Veit Roessner, Paramala Santosh, Emily Simonoff, Dejan
Published in: Neuroscience & Biobehavioral Reviews, Issue 149, 2023, Page(s) 105149, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2023.105149

Parental Experiences with Early Identification and Initial Care for their Child with Autism: Tailored Improvement Strategies

Author(s): Snijder MIJ, Langerak IPC, Kaijadoe SPT, Buruma ME, Verschuur R, Dietz C, Buitelaar JK, Oosterling IJ. J
Published in: Autism Dev Disord., Issue 2022 Aug;52(8), 2022, ISSN 0162-3257
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10803-021-05226-y

The sensory-first account of autism

Author(s): Terje Falck-Ytter, Giorgia Bussu
Published in: Neuroscience & Biobehavioral Reviews, Issue 153, 2024, Page(s) 105405, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2023.105405

A Genetic Bridge Between Medicine and Neurodiversity for Autism

Author(s): Claire S. Leblond, Thomas Rolland, Eli Barthome, Zakaria Mougin, Mathis Fleury, Christine Ecker, Stéf Bonnot-Briey, Freddy Cliquet, Anne-Claude Tabet, Anna Maruani, Boris Chaumette, Jonathan Green, Richard Delorme, Thomas Bourgeron
Published in: Annual Review of Genetics, Issue 58, 2024, Page(s) 487-512, ISSN 0066-4197
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-genet-111523-102614

Fine-grained topographic organization within somatosensory cortex during resting-state and emotional face-matching task and its association with ASD traits

Author(s): Christina Isakoglou, Koen V. Haak, Thomas Wolfers, Dorothea L. Floris, Alberto Llera, Marianne Oldehinkel, Natalie J. Forde, Bethany F. M. Oakley, Julian Tillmann, Rosemary J. Holt, Carolin Moessnang, Eva Loth, Thomas Bourgeron, Simon Baron-Cohen, Tony Charman, Tobias Banaschewski, Declan G. M. Murphy, Jan K. Buitelaar, Andre F. Marquand, Christian F. Beckmann
Published in: Translational Psychiatry, Issue 13, 2023, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-023-02559-3

Agomelatine in pediatric patients with moderate to severe major depressive disorder: an open-label extension study

Author(s): Celso Arango, Joerg M. Fegert, Françoise Picarel-Blanchot, Ute Marx, Lucie Truffaut-Chalet, Pierre-François Pénélaud, Jan Buitelaar, null null
Published in: European Child & Adolescent Psychiatry, Issue 34, 2025, Page(s) 1603-1614, ISSN 1018-8827
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00787-024-02587-4

Immune activation during pregnancy exacerbates ASD-related alterations in Shank3-deficient mice.

Author(s): Ekaterina Atanasova; Andrea Pérez Arévalo; Ines Graf; Rong Zhang; Juergen Bockmann; Anne-Kathrin Lutz; Tobias M. Boeckers
Published in: Mol Autism, Issue 1, 2023, ISSN 2040-2392
Publisher: BioMed Central
DOI: 10.1186/s13229-022-00532-3

Family history of ADHD associates with stronger problem‐solving skills amongst 2‐ to 3‐year‐olds

Author(s): Alexandra Hendry, Emily J. H. Jones, Linn Andersson‐Konke, Mary Agyapong, Tessel Bazelmans, Jannath Begum‐Ali, Mutluhan Ersoy, Amy Goodwin, Greg Pasco, Terje Falck‐Ytter, Mark H. Johnson, Tony Charman, null null
Published in: JCPP Advances, 2025, ISSN 2692-9384
Publisher: Wiley
DOI: 10.1002/jcv2.70009

Dissecting the 22q13 region to explore the genetic and phenotypic diversity of patients with Phelan-McDermid syndrome

Author(s): Aline Vitrac, Claire S. Leblond, Thomas Rolland, Freddy Cliquet, Alexandre Mathieu, Anna Maruani, Richard Delorme, Michael Schön, Andreas M. Grabrucker, Conny van Ravenswaaij-Arts, Katy Phelan, Anne-Claude Tabet, Thomas Bourgeron
Published in: European Journal of Medical Genetics, Issue 66, 2023, Page(s) 104732, ISSN 1769-7212
Publisher: Elsevier BV
DOI: 10.1016/j.ejmg.2023.104732

A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders

Author(s): Laura Lombardi, Sigrid Le Clerc, Ching-Lien Wu, Jihène Bouassida, Wahid Boukouaci, Sobika Sugusabesan, Jean-Romain Richard, Mohamed Lajnef, Maxime Tison, Philippe Le Corvoisier, Caroline Barau, Tobias Banaschewski, Rosemary Holt, Sarah Durston, Antonio M. Persico, Bethany Oakley, Eva Loth, Jan Buitelaar, Declan Murphy, Marion Leboyer, Jean-François Zagury, Ryad Tamouza
Published in: Translational Psychiatry, Issue 13, 2023, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-023-02550-y

Combined expansion and STED microscopy reveals altered fingerprints of postsynaptic nanostructure across brain regions in ASD-related SHANK3-deficiency

Author(s): Jan Philipp Delling, Helen Friedericke Bauer, Susanne Gerlach-Arbeiter, Michael Schön, Christian Jacob, Jan Wagner, Maria Teresa Pedro, Bernd Knöll, Tobias M. Boeckers
Published in: Molecular Psychiatry, 2024, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-024-02559-9

Different sensory dimensions in infancy are associated with separable etiological influences and with autistic traits in toddlerhood

Author(s): Giorgia Bussu, Ana Maria Portugal, Terje Falck‐Ytter
Published in: Journal of Child Psychology and Psychiatry, Issue 66, 2025, Page(s) 1182-1196, ISSN 0021-9630
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.14143

A stable and replicable neural signature of lifespan adversity in the adult brain

Author(s): Nathalie E. Holz, Mariam Zabihi, Seyed Mostafa Kia, Maximillian Monninger, Pascal-M. Aggensteiner, Sebastian Siehl, Dorothea L. Floris, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Mich
Published in: Nature Neuroscience, Issue 26, 2023, Page(s) 1603-1612, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-023-01410-8

Seven unique frequency profiles for scoring vigilance states in preclinical electrophysiological data

Author(s): Freja Gam Østergaard, Martien J. H. Kas
Published in: Frontiers in Neuroscience, Issue 19, 2025, ISSN 1662-453X
Publisher: Frontiers Media SA
DOI: 10.3389/fnins.2025.1488709

The Link between Autism and Sex-Related Neuroanatomy, and Associated Cognition and Gene Expression

Author(s): Floris DL, Peng H, Warrier V, Lombardo MV, Pretzsch CM, Moreau C, Tsompanidis A, Gong W, Mennes M, Llera A, van Rooij D, Oldehinkel M, Forde NJ, Charman T, Tillmann J, Banaschewski T, Moessnang C, Durston S, Holt RJ, Ecker C, Dell'Acqua F, Loth E, Bourgeron T, Murphy DGM, Marquand AF, Lai MC, Buitelaar JK, Baron-Cohen S, Beckmann CF; APEX Group; EU-AIMS LEAP Group.
Published in: Am J Psychiatry, Issue 2022 Nov 23, 2022, ISSN 0002-953X
Publisher: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220194

Patterns of Brain Maturation in Autism and Their Molecular Associations

Author(s): Charlotte M. Pretzsch, Martina Arenella, Jason P. Lerch, Michael V. Lombardo, Christian Beckmann, Tim Schaefer, Johanna Leyhausen, Caroline Gurr, Anke Bletsch, Lisa M. Berg, Hanna Seelemeyer, Dorothea L. Floris, Bethany Oakley, Eva Loth, Thomas Bourgeron, Tony Charman, Jan Buitelaar, Grainne McAlonan, Declan Murphy, Christine Ecker, null null, Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Tobias B
Published in: JAMA Psychiatry, Issue 81, 2024, Page(s) 1253, ISSN 2168-622X
Publisher: American Medical Association
DOI: 10.1001/jamapsychiatry.2024.3194

CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue

Author(s): Sarah Woelfle, Dhruva Deshpande, Simone Feldengut, Heiko Braak, Kelly Del Tredici, Francesco Roselli, Karl Deisseroth, Jens Michaelis, Tobias M. Boeckers, Michael Schön
Published in: BMC Biology, Issue 21, 2023, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-023-01582-6

Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders.

Author(s): Garrido D, Beretta S, Grabrucker S, Bauer HF, Bayer D, Sala C, Verpelli C, Roselli F, Bockmann J, Proepper C, Catanese A, Boeckers TM.
Published in: Mol Psychiatry, Issue 2022 Dec;27(12), 2022, Page(s) 4994-5006, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-022-01756-8

The gut microbiome as mediator between diet and its impact on immune function

Author(s): Shi H, Ter Horst R, Nielen S, Bloemendaal M, Jaeger M, Joosten I, Koenen H, Joosten LAB, Schweren LJS, Vasquez AA, Netea MG, Buitelaar J
Published in: Sci Rep, Issue 2022 Mar 25;12(1), 2022, Page(s) 5149, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-08544-y

Validation framework for in vivo digital measures

Author(s): Szczepan W. Baran, Susan E. Bolin, Stefano Gaburro, Marcel M. van Gaalen, Megan R. LaFollette, Chang-Ning Liu, Sean Maguire, Lucas P. J. J. Noldus, Natalie Bratcher-Petersen, Brian R. Berridge
Published in: Frontiers in Toxicology, Issue 6, 2025, ISSN 2673-3080
Publisher: Frontiers Media SA
DOI: 10.3389/ftox.2024.1484895

Downregulation of the Autism Spectrum Disorder Gene <i>Shank2</i> Decreases Bone Mass in Male Mice

Author(s): Mubashir Ahmad, Nadine Stirmlinger, Irfana Jan, Ulrich Stifel, Sooyeon Lee, Marcel Weingandt, Ulrike Kelp, Jürgen Bockmann, Anita Ignatius, Tobias M. Böckers, Jan Tuckermann
Published in: JBMR Plus, Issue 7, 2024, ISSN 2473-4039
Publisher: Oxford Academic
DOI: 10.1002/jbm4.10711

Fast annotation of rodent behaviors with AI assistance: Human observer and SmartAnnotator collaborate through active learning.

Author(s): Dam, E.A. van; Daniels, T.J.; Ottink, L.; van Gerven, M.A.J.; Noldus, L.P.J.J.
Published in: Proceedings of Measuring Behavior 2024, 13th International Conference on Methods and Techniques in Behavioral Research (Aberdeen, UK, 15-17 May 2024), 230-235., 2024
Publisher: Proceedings of Measuring Behavior

Fast annotation of rodent behaviors with AI assistance: Human observer and SmartAnnotator collaborate through active learning

Author(s): Dam, E.A. van; Daniels, T.J.; Ottink, L.; van Gerven, M.A.J.; Noldus, L.P.J.J.
Published in: Proceedings of Measuring Behavior, 2024
Publisher: Proceedings of Measuring Behavior
DOI: 10.6084/m9.figshare.25897855

Making sense of autism

Author(s): null null, Iris Riemersma
Published in: 2024
Publisher: University of Groningen Press
DOI: 10.33612/diss.935803086

Machine Learning Strategies, Behavioral Challenges and Practical Solutions

Author(s): Elsbeth van Dam
Published in: 2025
Publisher: Radboud University Press
DOI: 10.54195/9789465150864

Making sense of autism: The role of synaptic dysfunction in shaping sensory trajectories

Author(s): Iris W Riemersma
Published in: 2024
Publisher: Groningen University

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