Comorbid Analysis of Neurodevelopmental Disorders and Epilepsy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Report on developmental trajectories in PTCHD1 genetic mouse model

Report on developmental trajectories of co-morbidity phenotype expression in PTCHD1 genetic mouse model

Report on prototype of tablet based translational test battery for pre-schoolers

Prototype of tablet based translational test battery for pre-schoolers

Report on developmental trajectories in NRNX1 and SHANK3 genetic mouse models

Report on developmental trajectories of comorbidity phenotype expression in NRNX1 and SHANK3 genetic mouse models

Communication toolbox
Report on the critical developmental windows for treatment intervention

Report on the critical developmental windows for treatment intervention based on the expression of pathogenic pathways.

First collection of training materials
Internet-based discussion forum set up

Internetbased discussion forum set up

CANDY public website and social media channels

Pubblicazioni

Autistic and nonautistic adolescents do not differ in adaptation to gaze direction

Autori: Emma K. Ward, Jan K. Buitelaar, Sabine Hunnius
Pubblicato in: Autism Research, Numero 17, 2024, Pagina/e 1001-1015, ISSN 1939-3806
Editore: John Wiley & Sons Inc.
DOI: 10.1002/aur.3118

Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms.

Autori: Joanna Szopinska-Tokov; Sarita Dam; Jilly Naaijen; Prokopis Konstanti; Nanda Rommelse; Clara Belzer; Jan Buitelaar; Barbara Franke; Mirjam Bloemendaal; Esther Aarts; Alejandro Arias Vasquez
Pubblicato in: Microorganisms, Numero 3, 2020, ISSN 2076-2607
Editore: MDPI
DOI: 10.3390/microorganisms8030406

Cerebellar atypicalities in autism?

Autori: Charles Laidi; Dorothea L. Floris; Julian Tillmann; Yannis Elandaloussi; Mariam Zabihi; Tony Charman; Thomas Wolfers; Sarah Durston; Carolin Moessnang; Flavio Dell’Acqua; Christine Ecker; Eva Loth; Declan Murphy; Simon Baron-Cohen; Jan K. Buitelaar; Andre F. Marquand; Christian F. Beckmann; Vincent Frouin; Marion Leboyer; Edouard Duchesnay; Pierrick Coupé; Josselin Houenou; null Tobias Banasche
Pubblicato in: Biological Psychiatry, 92, 674 - 682, Numero 3, 2022, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2022.05.020

Global motion processing in infants’ visual cortex and the emergence of autism

Autori: Irzam Hardiansyah, Pär Nyström, Mark J. Taylor, Sven Bölte, Angelica Ronald, Terje Falck-Ytter
Pubblicato in: Communications Biology, Numero 6, 2023, ISSN 2399-3642
Editore: Nature Portfolio
DOI: 10.1038/s42003-023-04707-3

Disrupted extracellular matrix and cell cycle genes in autism-associated Shank3 deficiency are targeted by lithium

Autori: Valentin Ioannidis, Rakshita Pandey, Helen Friedericke Bauer, Michael Schön, Jürgen Bockmann, Tobias M. Boeckers, Anne-Kathrin Lutz
Pubblicato in: Molecular Psychiatry, Numero 29, 2024, Pagina/e 704-717, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-023-02362-y

Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research

Autori: Na Cai, Brad Verhulst, Ole A. Andreassen, Jan Buitelaar, Howard J. Edenberg, John M. Hettema, Michael Gandal, Andrew Grotzinger, Katherine Jonas, Phil Lee, Travis T. Mallard, Manuel Mattheisen, Michael C. Neale, John I. Nurnberger, Wouter J. Peyrot, Elliot M. Tucker-Drob, Jordan W. Smoller, Kenneth S. Kendler
Pubblicato in: Molecular Psychiatry, Numero 30, 2025, Pagina/e 1627-1638, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-024-02878-x

Suppression of Cofilin function in the somatosensory cortex alters social contact behavior in the BTBR mouse inbred line

Autori: Iris W Riemersma, Kevin G O Ike, Thomas Sollie, Elroy L Meijer, Robbert Havekes, Martien J H Kas
Pubblicato in: Cerebral Cortex, Numero 34, 2024, ISSN 1047-3211
Editore: Oxford University Press
DOI: 10.1093/cercor/bhae136

SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system

Autori: Mariagiovanna Malara; Anne-Kathrin Lutz; Berra Incearap; Helen Friedericke Bauer; Silvia Cursano; Katrin Volbracht; Joanna Janina Lerner; Rakshita Pandey; Jan Philipp Delling; Valentin Ioannidis; Andrea Pérez Arévalo; Jaime Eugenin von Bernhardi; Michael Schön; Jürgen Bockmann; Leda Dimou; Tobias M. Boeckers
Pubblicato in: Cell Mol Life Sci, Numero 3, 2022, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-022-04400-4

Coordinated Cortical Thickness Alterations Across Six Neurodevelopmental and Psychiatric Disorders

Autori: Hettwer MD, Larivière S, Park BY, van den Heuvel OA, Schmaal L, Andreassen OA, Ching CRK, Hoogman M, Buitelaar J, van Rooij D, Veltman DJ, Stein DJ, Franke B, van Erp TGM; ENIGMA ADHD Working Group; ENIGMA Autism Working Group; ENIGMA Bipolar Disorder Working Group; ENIGMA Major Depression Working Group; ENIGMA OCD Working Group; ENIGMA Schizophrenia Working Group; Jahanshad N, Thompson PM, Thomo
Pubblicato in: Nat Commun, Numero 2022 Nov 11;13(1), 2022, Pagina/e 6851, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-34367-6

Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis

Autori: Maja Rudling, Pär Nyström, Sven Bölte, Terje Falck‐Ytter
Pubblicato in: Journal of Child Psychology and Psychiatry, 2021, ISSN 0021-9630
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.13520

Evaluation of data imputation strategies in complex, deeply-phenotyped data sets: the case of the EU-AIMS Longitudinal European Autism Project.

Autori: Llera, A; Brammer, M; Oakley, B; Tillmann, J; Zabihi, M; Amelink, J S; Mei, T; Charman, T; Ecker, C; Dell'Acqua, F; Banaschewski, T; Moessnang, C; Baron-Cohen, S; Holt, R; Durston, S; Murphy, D; Loth, E; Buitelaar, J K; Floris, D L; Beckmann, C F
Pubblicato in: BMC Med Res Methodol, Numero 3, 2022, ISSN 1471-2288
Editore: BioMed Central
DOI: 10.1186/s12874-022-01656-z

Spatial and Temporal Gene Function Studies in Rodents: Towards Gene-Based Therapies for Autism Spectrum Disorder

Autori: Riemersma IW, Havekes R, Kas MJH
Pubblicato in: Genes, Numero 2021 Dec 23;13(1), 2021, Pagina/e 28, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13010028

Infant responses to direct gaze and associations to autism: A live eye-tracking study

Autori: Maja Rudling, Pär Nyström, Giorgia Bussu, Sven Bölte, Terje Falck-Ytter
Pubblicato in: Autism, Numero 28, 2024, Pagina/e 1677-1689, ISSN 1362-3613
Editore: SAGE Publications
DOI: 10.1177/13623613231203037

Age-related brain deviations and aggression

Autori: Holz NE, Floris DL, Llera A, Aggensteiner PM, Kia SM, Wolfers T, Baumeister S, Böttinger B, Glennon JC, Hoekstra PJ, Dietrich A, Saam MC, Schulze UME, Lythgoe DJ, Williams SCR, Santosh P, Rosa-Justicia M, Bargallo N, Castro-Fornieles J, Arango C, Penzol MJ, Walitza S, Meyer-Lindenberg A, Zwiers M, Franke B, Buitelaar J, Naaijen J, Brandeis D, Beckmann C, Banaschewski T, Marquand AF.
Pubblicato in: Psychol Med, Numero 2022 Apr 22, 2022, Pagina/e 1-10, ISSN 0033-2917
Editore: Cambridge University Press
DOI: 10.1017/s003329172200068x

Neurobiological Correlates of Change in Adaptive Behavior in Autism

Autori: Pretzsch CM, Schäfer T, Lombardo MV, Warrier V, Mann C, Bletsch A, Chatham CH, Floris DL, Tillmann J, Yousaf A, Jones E, […] Beckmann CF, Banaschewski T, Durston S, Freitag CM; EU-AIMS LEAP Group; Murphy DGM, Ecker C..
Pubblicato in: Am J Psychiatry, Numero 2022 May;179(5), 2022, Pagina/e 336-349, ISSN 0002-953X
Editore: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.21070711

What are you looking at? Gaze following with and without target objects in ASD and typical development.

Autori: Thorup E, Nyström P, Bölte S, Falck-Ytter T
Pubblicato in: Autism, Numero 2022 Oct;26(7), 2022, Pagina/e 1668-1680, ISSN 1362-3613
Editore: SAGE Publications
DOI: 10.1177/13623613211061940

Gray matter covariations in autism: out-of-sample replication using the ENIGMA autism cohort

Autori: Ting Mei, Alberto Llera, Natalie J. Forde, Daan van Rooij, Dorothea L. Floris, Christian F. Beckmann, Jan K. Buitelaar
Pubblicato in: Molecular Autism, Numero 15, 2024, ISSN 2040-2392
Editore: BioMed Central
DOI: 10.1186/s13229-024-00583-8

Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review

Autori: Tamouza R, Volt F, Richard JR, Wu CL, Bouassida J, Boukouaci W, Lansiaux P, Cappelli B, Scigliuolo GM, Rafii H, Kenzey C, Mezouad E, Naamoune S, Chami L, Lejuste F, Farge D, Gluckman E
Pubblicato in: Front Cell Dev Biol., Numero 2022 Jul 5;10, 2022, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fcell.2022.809686

From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans.

Autori: Ahmad J, Ellis C, Leech R, Voytek B, Garces P, Jones E, Buitelaar J, Loth E, Dos Santos FP, Amil AF, Verschure PFMJ, Murphy D, McAlonan G
Pubblicato in: Transl Psychiatry., Numero 2022 Nov 8;12(1):, 2022, Pagina/e 467, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-022-02218-z

Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology

Autori: Mei T, Forde NJ, Floris DL, Dell'Acqua F, Stones R, Ilioska I, Durston S, Moessnang C, Banaschewski T, Holt RJ, Baron-Cohen S, Rausch A, Loth E, Oakley B, Charman T, Ecker C, Murphy DGM; EU-AIMS LEAP group; Beckmann CF, Llera A, Buitelaar JK.
Pubblicato in: Biol Psychiatry Cogn Neurosci Neuroimaging, Numero 2022 Sep 6:S2451-9022(22), 2022, Pagina/e 00212-9, ISSN 2451-9022
Editore: Elsevier Inc. Al
DOI: 10.1016/j.bpsc.2022.08.011

Expression profiles of the autism-related SHANK proteins in the human brain

Autori: Sarah Woelfle, Maria T. Pedro, Jan Wagner, Michael Schön, Tobias M. Boeckers
Pubblicato in: BMC Biology, Numero 21, 2023, ISSN 1741-7007
Editore: BioMed Central
DOI: 10.1186/s12915-023-01712-0

Large‐scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents

Autori: F. Kurth, D. Schijven, O. A. van den Heuvel, M. Hoogman, D. van Rooij, D. J. Stein, J. K. Buitelaar, S. Bölte, G. Auzias, A. Kushki, G. Venkatasubramanian, K. Rubia, S. Bollmann, J. Isaksson, F. Jaspers‐Fayer, R. Marsh, M. C. Batistuzzo, P. D. Arnold, R. A. Bressan, S. E. Stewart, P. Gruner, L. Sorensen, P. M. Pan, T. J. Silk, R. C. Gur, A. I. Cubillo, J. Haavik, R. L. O'Gorman Tuura, C. A. Har
Pubblicato in: Human Brain Mapping, Numero 45, 2025, ISSN 1065-9471
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hbm.26754

Brain‐age prediction: Systematic evaluation of site effects, and sample age range and size

Autori: Yuetong Yu, Hao‐Qi Cui, Shalaila S. Haas, Faye New, Nicole Sanford, Kevin Yu, Denghuang Zhan, Guoyuan Yang, Jia‐Hong Gao, Dongtao Wei, Jiang Qiu, Nerisa Banaj, Dorret I. Boomsma, Alan Breier, Henry Brodaty, Randy L. Buckner, Jan K. Buitelaar, Dara M. Cannon, Xavier Caseras, Vincent P. Clark, Patricia J. Conrod, Fabrice Crivello, Eveline A. Crone, Udo Dannlowski, Christopher G. Davey, Lieuwe de
Pubblicato in: Human Brain Mapping, Numero 45, 2024, ISSN 1065-9471
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hbm.26768

SHANK3 Antibody Validation: Differential Performance in Western Blotting, Immunocyto- and Immunohistochemistry.

Autori: Anne-Kathrin Lutz; Helen Friedericke Bauer; Valentin Ioannidis; Michael Schön; Tobias M. Boeckers
Pubblicato in: Front Synaptic Neurosci ., Numero 3, 2022, ISSN 1663-3563
Editore: Frontiers Research Foundation
DOI: 10.3389/fnsyn.2022.890231

The breakdown of social looking

Autori: Terje Falck-Ytter
Pubblicato in: Neuroscience & Biobehavioral Reviews, Numero 161, 2024, Pagina/e 105689, ISSN 0149-7634
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2024.105689

Development of sex- and genotype-specific behavioral phenotypes in a Shank3 mouse model for neurodevelopmental disorders

Autori: Helen Friedericke Bauer, Jan Philipp Delling, Jürgen Bockmann, Tobias M. Boeckers, Michael Schön
Pubblicato in: Frontiers in Behavioral Neuroscience, Numero 16, 2023, ISSN 1662-5153
Editore: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2022.1051175

Phenotypic effects of genetic variants associated with autism

Autori: Thomas Rolland, Freddy Cliquet, Richard J. L. Anney, Clara Moreau, Nicolas Traut, Alexandre Mathieu, Guillaume Huguet, Jinjie Duan, Varun Warrier, Swan Portalier, Louise Dry, Claire S. Leblond, Elise Douard, Frédérique Amsellem, Simon Malesys, Anna Maruani, Roberto Toro, Anders D. Børglum, Jakob Grove, Simon Baron-Cohen, Alan Packer, Wendy K. Chung, Sébastien Jacquemont, Richard Delorme, Thoma
Pubblicato in: Nature Medicine, Numero 29, 2023, Pagina/e 1671-1680, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-023-02408-2

Autori: Berra Yildiz, Lisa Schiedt, Medhanie Mulaw, Jürgen Bockmann, Sarah Jesse, Anne-Kathrin Lutz, Tobias M. Boeckers
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 11, 2023, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2023.1243299

Patterns of connectome variability in autism across five functional activation tasks: findings from the LEAP project

Autori: Looden T, Floris DL, Llera A, Chauvin RJ, Charman T, Banaschewski T, Murphy D, Marquand AF, Buitelaar JK, Beckmann CF; AIMS-2-TRIALS group
Pubblicato in: Mol Autism, Numero 2022 Dec 27;13(1), 2022, Pagina/e 53, ISSN 2040-2392
Editore: BioMed Central
DOI: 10.1186/s13229-022-00529

Cross-sectional and longitudinal neuroanatomical profiles of distinct clinical (adaptive) outcomes in autism

Autori: Charlotte M. Pretzsch, Dorothea L. Floris, Tim Schäfer, Anke Bletsch, Caroline Gurr, Michael V. Lombardo, Chris H. Chatham, Julian Tillmann, Tony Charman, Martina Arenella, Emily Jones, Sara Ambrosino, Thomas Bourgeron, Guillaume Dumas, Freddy Cliquet, Claire S. Leblond, Eva Loth, Bethany Oakley, Jan K. Buitelaar, Simon Baron-Cohen, Christian F. Beckmann, Antonio M. Persico, Tobias Banaschewski,
Pubblicato in: Molecular Psychiatry, Numero 28, 2023, Pagina/e 2158-2169, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-023-02016-z

A multimodal neural signature of face processing in autism within the fusiform gyrus

Autori: Dorothea L. Floris, Alberto Llera, Mariam Zabihi, Carolin Moessnang, Emily J. H. Jones, Luke Mason, Rianne Haartsen, Nathalie E. Holz, Ting Mei, Camille Elleaume, Bruno Hebling Vieira, Charlotte M. Pretzsch, Natalie J. Forde, Sarah Baumeister, Flavio Dell’Acqua, Sarah Durston, Tobias Banaschewski, Christine Ecker, Rosemary J. Holt, Simon Baron-Cohen, Thomas Bourgeron, Tony Charman, Eva Loth, Dec
Pubblicato in: Nature Mental Health, Numero 3, 2025, Pagina/e 31-45, ISSN 2731-6076
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44220-024-00349-4

Qualitative differences in the spatiotemporal brain states supporting configural face processing emerge in adolescence in autism

Autori: Haartsen R, Mason L, Garces P, Gui A, Charman T, Tillmann J, Johnson MH, Buitelaar JK, Loth E, Murphy D, Jones EJH; EU-AIMS LEAP group.
Pubblicato in: Cortex, Numero 2022 Oct;155, 2022, Pagina/e 13-29, ISSN 0010-9452
Editore: Masson Publishing
DOI: 10.1016/j.cortex.2022.06.010

Local Molecular and Global Connectomic Contributions to Cross-Disorder Cortical Abnormalities

Autori: Hansen JY, Shafiei G, Vogel JW, Smart K, Bearden CE, Hoogman M, Franke B, van Rooij D, Buitelaar J, McDonald CR, Sisodiya SM, Schmaal L, Veltman DJ, van den Heuvel OA, Stein DJ, van Erp TGM, Ching CRK, Andreassen OA, Hajek T, Opel N, Modinos G, Aleman A, van der Werf Y, Jahanshad N, Thomopoulos SI, Thompson PM, Carson RE, Dagher A, Misic B.
Pubblicato in: Nat Commun, Numero 2022 Aug 10;13(1):, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-32420-y

Pre‐pragmatic language use in toddlerhood: Developmental antecedents, aetiological factors, and associations to autism

Autori: Maja Rudling, Ana Maria Portugal, Sven Bölte, Terje Falck‐Ytter
Pubblicato in: JCPP Advances, Numero 3, 2023, ISSN 2692-9384
Editore: Wiley-Blackwell
DOI: 10.1002/jcv2.12135

Does the current state of biomarker discovery in autism reflect the limits of reductionism in precision medicine? Suggestions for an integrative approach that considers dynamic mechanisms between brain, body, and the social environment

Autori: Eva Loth
Pubblicato in: Frontiers in Psychiatry, Numero 14, 2023, ISSN 1664-0640
Editore: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2023.1085445

Attention-deficit/hyperactivity disorder

Autori: Stephen V. Faraone, Mark A. Bellgrove, Isabell Brikell, Samuele Cortese, Catharina A. Hartman, Chris Hollis, Jeffrey H. Newcorn, Alexandra Philipsen, Guilherme V. Polanczyk, Katya Rubia, Margaret H. Sibley, Jan K. Buitelaar
Pubblicato in: Nature Reviews Disease Primers, Numero 10, 2024, ISSN 2056-676X
Editore: Nature Portfolio
DOI: 10.1038/s41572-024-00495-0

SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(−/−) Mice

Autori: Lutz, Anne-Kathrin; Pérez Arévalo, Andrea; Ioannidis, Valentin; Stirmlinger, Nadine; Demestre, Maria; Delorme, Richard; Bourgeron, Thomas; Boeckers, Tobias M.
Pubblicato in: Frontiers in Molecular Neuroscience, Numero 3, 2021, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.18725/oparu-40117

Less frequent face looking in infancy is related to autism likelihood status but not diagnosis: A study of parent-infant interaction

Autori: Emilia Thorup, Sven Bölte, Terje Falck-Ytter
Pubblicato in: Research in Autism Spectrum Disorders, Numero 115, 2024, Pagina/e 102422, ISSN 1750-9467
Editore: Elsevier BV
DOI: 10.1016/j.rasd.2024.102422

Tracing the paths: a systematic review of mediators of complex trauma and complex post-traumatic stress disorder

Autori: Joseph Harris, Eva Loth, Vaheshta Sethna
Pubblicato in: Frontiers in Psychiatry, Numero 15, 2024, ISSN 1664-0640
Editore: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2024.1331256

How 18-month-olds with Later Autism Look at Other Children Interacting: The Timing of Gaze Allocation

Autori: Charlotte Viktorsson, Sven Bölte, Terje Falck-Ytter
Pubblicato in: Journal of Autism and Developmental Disorders, 2023, ISSN 0162-3257
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10803-023-06118-z

Structural models of genome-wide covariance identify multiple common dimensions in autism

Autori: Lucía de Hoyos, Maria T. Barendse, Fenja Schlag, Marjolein M. J. van Donkelaar, Ellen Verhoef, Chin Yang Shapland, Alexander Klassmann, Jan Buitelaar, Brad Verhulst, Simon E. Fisher, Dheeraj Rai, Beate St Pourcain
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-46128-8

Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications

Autori: Delling JP, Boeckers TM
Pubblicato in: J Neurodev Disord, Numero 2021 Nov 16;13(1), 2021, Pagina/e 55, ISSN 1866-1955
Editore: Springer Nature
DOI: 10.1186/s11689-021-09397-8

Decomposing the Brain in Autism: Linking Behavioral Domains to Neuroanatomical Variation and Genomic Underpinnings

Autori: Hanna Seelemeyer, Caroline Gurr, Johanna Leyhausen, Lisa M. Berg, Charlotte M. Pretzsch, Tim Schäfer, Bassem Hermila, Christine M. Freitag, Eva Loth, Bethany Oakley, Luke Mason, Jan K. Buitelaar, Christian F. Beckmann, Dorothea L. Floris, Tony Charman, Tobias Banaschewski, Emily Jones, Thomas Bourgeron, Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Tobias Banaschewski, Simon Baron-Cohen, Sarah Ba
Pubblicato in: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2025, ISSN 2451-9022
Editore: Elsevier BV
DOI: 10.1016/j.bpsc.2024.12.003

Deletion of the Autism-Associated Protein SHANK3 Abolishes Structural Synaptic Plasticity after Brain Trauma.

Autori: Urrutia-Ruiz, Carolina; Rombach, Daniel; Cursano, Silvia; Gerlach-Arbeiter, Susanne; Schoen, Michael; Bockmann, Juergen; Demestre, Maria; Boeckers, Tobias M.; Pérez-Mediavilla, Alberto
Pubblicato in: International Journal of Molecular Sciences; Volume 23; Numero 11; Pages: 6081, Numero 3, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23116081

Low-grade inflammation as mediator between diet and behavioral disinhibition: A UK Biobank study.

Autori: Shi H, Schweren LJS, Ter Horst R, Bloemendaal M, van Rooij D, Vasquez AA, Hartman CA, Buitelaar JK
Pubblicato in: Brain Behav Immun, Numero 2022 Nov;106, 2022, Pagina/e 100-110., ISSN 0889-1591
Editore: Academic Press
DOI: 10.1016/j.bbi.2022.07.165

Connectome-wide Mega-analysis Reveals Robust Patterns of Atypical Functional Connectivity in Autism

Autori: Iva Ilioska, Marianne Oldehinkel, Alberto Llera, Sidhant Chopra, Tristan Looden, Roselyne Chauvin, Daan Van Rooij, Dorothea L. Floris, Julian Tillmann, Carolin Moessnang, Tobias Banaschewski, Rosemary J. Holt, Eva Loth, Tony Charman, Declan G.M. Murphy, Christine Ecker, Maarten Mennes, Christian F. Beckmann, Alex Fornito, Jan K. Buitelaar
Pubblicato in: Biological Psychiatry, Numero 94, 2023, Pagina/e 29-39, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2022.12.018

The future of child and adolescent clinical psychopharmacology: A systematic review of phase 2, 3, or 4 randomized controlled trials of pharmacologic agents without regulatory approval or for unapproved indications

Autori: Samuele Cortese, Katherine McGinn, Mikkel Højlund, Alan Apter, Celso Arango, Immaculada Baeza, Tobias Banaschewski, Jan Buitelaar, Josefina Castro-Fornieles, David Coghill, David Cohen, Edna Grünblatt, Pieter J. Hoekstra, Anthony James, Pia Jeppesen, Péter Nagy, Anne Katrine Pagsberg, Mara Parellada, Antonio M. Persico, Diane Purper-Ouakil, Veit Roessner, Paramala Santosh, Emily Simonoff, Dejan
Pubblicato in: Neuroscience & Biobehavioral Reviews, Numero 149, 2023, Pagina/e 105149, ISSN 0149-7634
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2023.105149

Parental Experiences with Early Identification and Initial Care for their Child with Autism: Tailored Improvement Strategies

Autori: Snijder MIJ, Langerak IPC, Kaijadoe SPT, Buruma ME, Verschuur R, Dietz C, Buitelaar JK, Oosterling IJ. J
Pubblicato in: Autism Dev Disord., Numero 2022 Aug;52(8), 2022, ISSN 0162-3257
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10803-021-05226-y

The sensory-first account of autism

Autori: Terje Falck-Ytter, Giorgia Bussu
Pubblicato in: Neuroscience & Biobehavioral Reviews, Numero 153, 2024, Pagina/e 105405, ISSN 0149-7634
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2023.105405

A Genetic Bridge Between Medicine and Neurodiversity for Autism

Autori: Claire S. Leblond, Thomas Rolland, Eli Barthome, Zakaria Mougin, Mathis Fleury, Christine Ecker, Stéf Bonnot-Briey, Freddy Cliquet, Anne-Claude Tabet, Anna Maruani, Boris Chaumette, Jonathan Green, Richard Delorme, Thomas Bourgeron
Pubblicato in: Annual Review of Genetics, Numero 58, 2024, Pagina/e 487-512, ISSN 0066-4197
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-genet-111523-102614

Fine-grained topographic organization within somatosensory cortex during resting-state and emotional face-matching task and its association with ASD traits

Autori: Christina Isakoglou, Koen V. Haak, Thomas Wolfers, Dorothea L. Floris, Alberto Llera, Marianne Oldehinkel, Natalie J. Forde, Bethany F. M. Oakley, Julian Tillmann, Rosemary J. Holt, Carolin Moessnang, Eva Loth, Thomas Bourgeron, Simon Baron-Cohen, Tony Charman, Tobias Banaschewski, Declan G. M. Murphy, Jan K. Buitelaar, Andre F. Marquand, Christian F. Beckmann
Pubblicato in: Translational Psychiatry, Numero 13, 2023, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-023-02559-3

Agomelatine in pediatric patients with moderate to severe major depressive disorder: an open-label extension study

Autori: Celso Arango, Joerg M. Fegert, Françoise Picarel-Blanchot, Ute Marx, Lucie Truffaut-Chalet, Pierre-François Pénélaud, Jan Buitelaar, null null
Pubblicato in: European Child & Adolescent Psychiatry, Numero 34, 2025, Pagina/e 1603-1614, ISSN 1018-8827
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00787-024-02587-4

Immune activation during pregnancy exacerbates ASD-related alterations in Shank3-deficient mice.

Autori: Ekaterina Atanasova; Andrea Pérez Arévalo; Ines Graf; Rong Zhang; Juergen Bockmann; Anne-Kathrin Lutz; Tobias M. Boeckers
Pubblicato in: Mol Autism, Numero 1, 2023, ISSN 2040-2392
Editore: BioMed Central
DOI: 10.1186/s13229-022-00532-3

Family history of ADHD associates with stronger problem‐solving skills amongst 2‐ to 3‐year‐olds

Autori: Alexandra Hendry, Emily J. H. Jones, Linn Andersson‐Konke, Mary Agyapong, Tessel Bazelmans, Jannath Begum‐Ali, Mutluhan Ersoy, Amy Goodwin, Greg Pasco, Terje Falck‐Ytter, Mark H. Johnson, Tony Charman, null null
Pubblicato in: JCPP Advances, 2025, ISSN 2692-9384
Editore: Wiley
DOI: 10.1002/jcv2.70009

Dissecting the 22q13 region to explore the genetic and phenotypic diversity of patients with Phelan-McDermid syndrome

Autori: Aline Vitrac, Claire S. Leblond, Thomas Rolland, Freddy Cliquet, Alexandre Mathieu, Anna Maruani, Richard Delorme, Michael Schön, Andreas M. Grabrucker, Conny van Ravenswaaij-Arts, Katy Phelan, Anne-Claude Tabet, Thomas Bourgeron
Pubblicato in: European Journal of Medical Genetics, Numero 66, 2023, Pagina/e 104732, ISSN 1769-7212
Editore: Elsevier BV
DOI: 10.1016/j.ejmg.2023.104732

A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders

Autori: Laura Lombardi, Sigrid Le Clerc, Ching-Lien Wu, Jihène Bouassida, Wahid Boukouaci, Sobika Sugusabesan, Jean-Romain Richard, Mohamed Lajnef, Maxime Tison, Philippe Le Corvoisier, Caroline Barau, Tobias Banaschewski, Rosemary Holt, Sarah Durston, Antonio M. Persico, Bethany Oakley, Eva Loth, Jan Buitelaar, Declan Murphy, Marion Leboyer, Jean-François Zagury, Ryad Tamouza
Pubblicato in: Translational Psychiatry, Numero 13, 2023, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-023-02550-y

Combined expansion and STED microscopy reveals altered fingerprints of postsynaptic nanostructure across brain regions in ASD-related SHANK3-deficiency

Autori: Jan Philipp Delling, Helen Friedericke Bauer, Susanne Gerlach-Arbeiter, Michael Schön, Christian Jacob, Jan Wagner, Maria Teresa Pedro, Bernd Knöll, Tobias M. Boeckers
Pubblicato in: Molecular Psychiatry, 2024, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-024-02559-9

Different sensory dimensions in infancy are associated with separable etiological influences and with autistic traits in toddlerhood

Autori: Giorgia Bussu, Ana Maria Portugal, Terje Falck‐Ytter
Pubblicato in: Journal of Child Psychology and Psychiatry, Numero 66, 2025, Pagina/e 1182-1196, ISSN 0021-9630
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.14143

A stable and replicable neural signature of lifespan adversity in the adult brain

Autori: Nathalie E. Holz, Mariam Zabihi, Seyed Mostafa Kia, Maximillian Monninger, Pascal-M. Aggensteiner, Sebastian Siehl, Dorothea L. Floris, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Mich
Pubblicato in: Nature Neuroscience, Numero 26, 2023, Pagina/e 1603-1612, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-023-01410-8

Seven unique frequency profiles for scoring vigilance states in preclinical electrophysiological data

Autori: Freja Gam Østergaard, Martien J. H. Kas
Pubblicato in: Frontiers in Neuroscience, Numero 19, 2025, ISSN 1662-453X
Editore: Frontiers Media SA
DOI: 10.3389/fnins.2025.1488709

The Link between Autism and Sex-Related Neuroanatomy, and Associated Cognition and Gene Expression

Autori: Floris DL, Peng H, Warrier V, Lombardo MV, Pretzsch CM, Moreau C, Tsompanidis A, Gong W, Mennes M, Llera A, van Rooij D, Oldehinkel M, Forde NJ, Charman T, Tillmann J, Banaschewski T, Moessnang C, Durston S, Holt RJ, Ecker C, Dell'Acqua F, Loth E, Bourgeron T, Murphy DGM, Marquand AF, Lai MC, Buitelaar JK, Baron-Cohen S, Beckmann CF; APEX Group; EU-AIMS LEAP Group.
Pubblicato in: Am J Psychiatry, Numero 2022 Nov 23, 2022, ISSN 0002-953X
Editore: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220194

Patterns of Brain Maturation in Autism and Their Molecular Associations

Autori: Charlotte M. Pretzsch, Martina Arenella, Jason P. Lerch, Michael V. Lombardo, Christian Beckmann, Tim Schaefer, Johanna Leyhausen, Caroline Gurr, Anke Bletsch, Lisa M. Berg, Hanna Seelemeyer, Dorothea L. Floris, Bethany Oakley, Eva Loth, Thomas Bourgeron, Tony Charman, Jan Buitelaar, Grainne McAlonan, Declan Murphy, Christine Ecker, null null, Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Tobias B
Pubblicato in: JAMA Psychiatry, Numero 81, 2024, Pagina/e 1253, ISSN 2168-622X
Editore: American Medical Association
DOI: 10.1001/jamapsychiatry.2024.3194

CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue

Autori: Sarah Woelfle, Dhruva Deshpande, Simone Feldengut, Heiko Braak, Kelly Del Tredici, Francesco Roselli, Karl Deisseroth, Jens Michaelis, Tobias M. Boeckers, Michael Schön
Pubblicato in: BMC Biology, Numero 21, 2023, ISSN 1741-7007
Editore: BioMed Central
DOI: 10.1186/s12915-023-01582-6

Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders.

Autori: Garrido D, Beretta S, Grabrucker S, Bauer HF, Bayer D, Sala C, Verpelli C, Roselli F, Bockmann J, Proepper C, Catanese A, Boeckers TM.
Pubblicato in: Mol Psychiatry, Numero 2022 Dec;27(12), 2022, Pagina/e 4994-5006, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-022-01756-8

The gut microbiome as mediator between diet and its impact on immune function

Autori: Shi H, Ter Horst R, Nielen S, Bloemendaal M, Jaeger M, Joosten I, Koenen H, Joosten LAB, Schweren LJS, Vasquez AA, Netea MG, Buitelaar J
Pubblicato in: Sci Rep, Numero 2022 Mar 25;12(1), 2022, Pagina/e 5149, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-08544-y

Validation framework for in vivo digital measures

Autori: Szczepan W. Baran, Susan E. Bolin, Stefano Gaburro, Marcel M. van Gaalen, Megan R. LaFollette, Chang-Ning Liu, Sean Maguire, Lucas P. J. J. Noldus, Natalie Bratcher-Petersen, Brian R. Berridge
Pubblicato in: Frontiers in Toxicology, Numero 6, 2025, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/ftox.2024.1484895

Downregulation of the Autism Spectrum Disorder Gene <i>Shank2</i> Decreases Bone Mass in Male Mice

Autori: Mubashir Ahmad, Nadine Stirmlinger, Irfana Jan, Ulrich Stifel, Sooyeon Lee, Marcel Weingandt, Ulrike Kelp, Jürgen Bockmann, Anita Ignatius, Tobias M. Böckers, Jan Tuckermann
Pubblicato in: JBMR Plus, Numero 7, 2024, ISSN 2473-4039
Editore: Oxford Academic
DOI: 10.1002/jbm4.10711

Fast annotation of rodent behaviors with AI assistance: Human observer and SmartAnnotator collaborate through active learning.

Autori: Dam, E.A. van; Daniels, T.J.; Ottink, L.; van Gerven, M.A.J.; Noldus, L.P.J.J.
Pubblicato in: Proceedings of Measuring Behavior 2024, 13th International Conference on Methods and Techniques in Behavioral Research (Aberdeen, UK, 15-17 May 2024), 230-235., 2024
Editore: Proceedings of Measuring Behavior

Fast annotation of rodent behaviors with AI assistance: Human observer and SmartAnnotator collaborate through active learning

Autori: Dam, E.A. van; Daniels, T.J.; Ottink, L.; van Gerven, M.A.J.; Noldus, L.P.J.J.
Pubblicato in: Proceedings of Measuring Behavior, 2024
Editore: Proceedings of Measuring Behavior
DOI: 10.6084/m9.figshare.25897855

Making sense of autism

Autori: null null, Iris Riemersma
Pubblicato in: 2024
Editore: University of Groningen Press
DOI: 10.33612/diss.935803086

Machine Learning Strategies, Behavioral Challenges and Practical Solutions

Autori: Elsbeth van Dam
Pubblicato in: 2025
Editore: Radboud University Press
DOI: 10.54195/9789465150864

Making sense of autism: The role of synaptic dysfunction in shaping sensory trajectories

Autori: Iris W Riemersma
Pubblicato in: 2024
Editore: Groningen University

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