Comorbid Analysis of Neurodevelopmental Disorders and Epilepsy

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Report on developmental trajectories in NRNX1 and SHANK3 genetic mouse models

Report on developmental trajectories of comorbidity phenotype expression in NRNX1 and SHANK3 genetic mouse models

First collection of training materials
Internet-based discussion forum set up

Internetbased discussion forum set up

CANDY public website and social media channels

Publications

Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms.

Auteurs: Joanna Szopinska-Tokov; Sarita Dam; Jilly Naaijen; Prokopis Konstanti; Nanda Rommelse; Clara Belzer; Jan Buitelaar; Barbara Franke; Mirjam Bloemendaal; Esther Aarts; Alejandro Arias Vasquez
Publié dans: Microorganisms, Numéro 3, 2020, ISSN 2076-2607
Éditeur: MDPI
DOI: 10.3390/microorganisms8030406

Cerebellar atypicalities in autism?

Auteurs: Charles Laidi; Dorothea L. Floris; Julian Tillmann; Yannis Elandaloussi; Mariam Zabihi; Tony Charman; Thomas Wolfers; Sarah Durston; Carolin Moessnang; Flavio Dell’Acqua; Christine Ecker; Eva Loth; Declan Murphy; Simon Baron-Cohen; Jan K. Buitelaar; Andre F. Marquand; Christian F. Beckmann; Vincent Frouin; Marion Leboyer; Edouard Duchesnay; Pierrick Coupé; Josselin Houenou; null Tobias Banasche
Publié dans: Biological Psychiatry, 92, 674 - 682, Numéro 3, 2022, ISSN 0006-3223
Éditeur: Elsevier BV
DOI: 10.1016/j.biopsych.2022.05.020

SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system

Auteurs: Mariagiovanna Malara; Anne-Kathrin Lutz; Berra Incearap; Helen Friedericke Bauer; Silvia Cursano; Katrin Volbracht; Joanna Janina Lerner; Rakshita Pandey; Jan Philipp Delling; Valentin Ioannidis; Andrea Pérez Arévalo; Jaime Eugenin von Bernhardi; Michael Schön; Jürgen Bockmann; Leda Dimou; Tobias M. Boeckers
Publié dans: Cell Mol Life Sci, Numéro 3, 2022, ISSN 1420-682X
Éditeur: Birkhauser Verlag
DOI: 10.1007/s00018-022-04400-4

Coordinated Cortical Thickness Alterations Across Six Neurodevelopmental and Psychiatric Disorders

Auteurs: Hettwer MD, Larivière S, Park BY, van den Heuvel OA, Schmaal L, Andreassen OA, Ching CRK, Hoogman M, Buitelaar J, van Rooij D, Veltman DJ, Stein DJ, Franke B, van Erp TGM; ENIGMA ADHD Working Group; ENIGMA Autism Working Group; ENIGMA Bipolar Disorder Working Group; ENIGMA Major Depression Working Group; ENIGMA OCD Working Group; ENIGMA Schizophrenia Working Group; Jahanshad N, Thompson PM, Thomo
Publié dans: Nat Commun, Numéro 2022 Nov 11;13(1), 2022, Page(s) 6851, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-34367-6

Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis

Auteurs: Maja Rudling, Pär Nyström, Sven Bölte, Terje Falck‐Ytter
Publié dans: Journal of Child Psychology and Psychiatry, 2021, ISSN 0021-9630
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.13520

Evaluation of data imputation strategies in complex, deeply-phenotyped data sets: the case of the EU-AIMS Longitudinal European Autism Project.

Auteurs: Llera, A; Brammer, M; Oakley, B; Tillmann, J; Zabihi, M; Amelink, J S; Mei, T; Charman, T; Ecker, C; Dell'Acqua, F; Banaschewski, T; Moessnang, C; Baron-Cohen, S; Holt, R; Durston, S; Murphy, D; Loth, E; Buitelaar, J K; Floris, D L; Beckmann, C F
Publié dans: BMC Med Res Methodol, Numéro 3, 2022, ISSN 1471-2288
Éditeur: BioMed Central
DOI: 10.1186/s12874-022-01656-z

Spatial and Temporal Gene Function Studies in Rodents: Towards Gene-Based Therapies for Autism Spectrum Disorder

Auteurs: Riemersma IW, Havekes R, Kas MJH
Publié dans: Genes, Numéro 2021 Dec 23;13(1), 2021, Page(s) 28, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13010028

Age-related brain deviations and aggression

Auteurs: Holz NE, Floris DL, Llera A, Aggensteiner PM, Kia SM, Wolfers T, Baumeister S, Böttinger B, Glennon JC, Hoekstra PJ, Dietrich A, Saam MC, Schulze UME, Lythgoe DJ, Williams SCR, Santosh P, Rosa-Justicia M, Bargallo N, Castro-Fornieles J, Arango C, Penzol MJ, Walitza S, Meyer-Lindenberg A, Zwiers M, Franke B, Buitelaar J, Naaijen J, Brandeis D, Beckmann C, Banaschewski T, Marquand AF.
Publié dans: Psychol Med, Numéro 2022 Apr 22, 2022, Page(s) 1-10, ISSN 0033-2917
Éditeur: Cambridge University Press
DOI: 10.1017/s003329172200068x

Neurobiological Correlates of Change in Adaptive Behavior in Autism

Auteurs: Pretzsch CM, Schäfer T, Lombardo MV, Warrier V, Mann C, Bletsch A, Chatham CH, Floris DL, Tillmann J, Yousaf A, Jones E, […] Beckmann CF, Banaschewski T, Durston S, Freitag CM; EU-AIMS LEAP Group; Murphy DGM, Ecker C..
Publié dans: Am J Psychiatry, Numéro 2022 May;179(5), 2022, Page(s) 336-349, ISSN 0002-953X
Éditeur: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.21070711

What are you looking at? Gaze following with and without target objects in ASD and typical development.

Auteurs: Thorup E, Nyström P, Bölte S, Falck-Ytter T
Publié dans: Autism, Numéro 2022 Oct;26(7), 2022, Page(s) 1668-1680, ISSN 1362-3613
Éditeur: SAGE Publications
DOI: 10.1177/13623613211061940

Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review

Auteurs: Tamouza R, Volt F, Richard JR, Wu CL, Bouassida J, Boukouaci W, Lansiaux P, Cappelli B, Scigliuolo GM, Rafii H, Kenzey C, Mezouad E, Naamoune S, Chami L, Lejuste F, Farge D, Gluckman E
Publié dans: Front Cell Dev Biol., Numéro 2022 Jul 5;10, 2022, ISSN 1662-5099
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fcell.2022.809686

From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans.

Auteurs: Ahmad J, Ellis C, Leech R, Voytek B, Garces P, Jones E, Buitelaar J, Loth E, Dos Santos FP, Amil AF, Verschure PFMJ, Murphy D, McAlonan G
Publié dans: Transl Psychiatry., Numéro 2022 Nov 8;12(1):, 2022, Page(s) 467, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-022-02218-z

Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology

Auteurs: Mei T, Forde NJ, Floris DL, Dell'Acqua F, Stones R, Ilioska I, Durston S, Moessnang C, Banaschewski T, Holt RJ, Baron-Cohen S, Rausch A, Loth E, Oakley B, Charman T, Ecker C, Murphy DGM; EU-AIMS LEAP group; Beckmann CF, Llera A, Buitelaar JK.
Publié dans: Biol Psychiatry Cogn Neurosci Neuroimaging, Numéro 2022 Sep 6:S2451-9022(22), 2022, Page(s) 00212-9, ISSN 2451-9022
Éditeur: Elsevier Inc. Al
DOI: 10.1016/j.bpsc.2022.08.011

SHANK3 Antibody Validation: Differential Performance in Western Blotting, Immunocyto- and Immunohistochemistry.

Auteurs: Anne-Kathrin Lutz; Helen Friedericke Bauer; Valentin Ioannidis; Michael Schön; Tobias M. Boeckers
Publié dans: Front Synaptic Neurosci ., Numéro 3, 2022, ISSN 1663-3563
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnsyn.2022.890231

Patterns of connectome variability in autism across five functional activation tasks: findings from the LEAP project

Auteurs: Looden T, Floris DL, Llera A, Chauvin RJ, Charman T, Banaschewski T, Murphy D, Marquand AF, Buitelaar JK, Beckmann CF; AIMS-2-TRIALS group
Publié dans: Mol Autism, Numéro 2022 Dec 27;13(1), 2022, Page(s) 53, ISSN 2040-2392
Éditeur: BioMed Central
DOI: 10.1186/s13229-022-00529

Qualitative differences in the spatiotemporal brain states supporting configural face processing emerge in adolescence in autism

Auteurs: Haartsen R, Mason L, Garces P, Gui A, Charman T, Tillmann J, Johnson MH, Buitelaar JK, Loth E, Murphy D, Jones EJH; EU-AIMS LEAP group.
Publié dans: Cortex, Numéro 2022 Oct;155, 2022, Page(s) 13-29, ISSN 0010-9452
Éditeur: Masson Publishing
DOI: 10.1016/j.cortex.2022.06.010

Local Molecular and Global Connectomic Contributions to Cross-Disorder Cortical Abnormalities

Auteurs: Hansen JY, Shafiei G, Vogel JW, Smart K, Bearden CE, Hoogman M, Franke B, van Rooij D, Buitelaar J, McDonald CR, Sisodiya SM, Schmaal L, Veltman DJ, van den Heuvel OA, Stein DJ, van Erp TGM, Ching CRK, Andreassen OA, Hajek T, Opel N, Modinos G, Aleman A, van der Werf Y, Jahanshad N, Thomopoulos SI, Thompson PM, Carson RE, Dagher A, Misic B.
Publié dans: Nat Commun, Numéro 2022 Aug 10;13(1):, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-32420-y

SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(−/−) Mice

Auteurs: Lutz, Anne-Kathrin; Pérez Arévalo, Andrea; Ioannidis, Valentin; Stirmlinger, Nadine; Demestre, Maria; Delorme, Richard; Bourgeron, Thomas; Boeckers, Tobias M.
Publié dans: Frontiers in Molecular Neuroscience, Numéro 3, 2021, ISSN 1662-5099
Éditeur: Frontiers Research Foundation
DOI: 10.18725/oparu-40117

Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications

Auteurs: Delling JP, Boeckers TM
Publié dans: J Neurodev Disord, Numéro 2021 Nov 16;13(1), 2021, Page(s) 55, ISSN 1866-1955
Éditeur: Springer Nature
DOI: 10.1186/s11689-021-09397-8

Deletion of the Autism-Associated Protein SHANK3 Abolishes Structural Synaptic Plasticity after Brain Trauma.

Auteurs: Urrutia-Ruiz, Carolina; Rombach, Daniel; Cursano, Silvia; Gerlach-Arbeiter, Susanne; Schoen, Michael; Bockmann, Juergen; Demestre, Maria; Boeckers, Tobias M.; Pérez-Mediavilla, Alberto
Publié dans: International Journal of Molecular Sciences; Volume 23; Numéro 11; Pages: 6081, Numéro 3, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23116081

Low-grade inflammation as mediator between diet and behavioral disinhibition: A UK Biobank study.

Auteurs: Shi H, Schweren LJS, Ter Horst R, Bloemendaal M, van Rooij D, Vasquez AA, Hartman CA, Buitelaar JK
Publié dans: Brain Behav Immun, Numéro 2022 Nov;106, 2022, Page(s) 100-110., ISSN 0889-1591
Éditeur: Academic Press
DOI: 10.1016/j.bbi.2022.07.165

Parental Experiences with Early Identification and Initial Care for their Child with Autism: Tailored Improvement Strategies

Auteurs: Snijder MIJ, Langerak IPC, Kaijadoe SPT, Buruma ME, Verschuur R, Dietz C, Buitelaar JK, Oosterling IJ. J
Publié dans: Autism Dev Disord., Numéro 2022 Aug;52(8), 2022, ISSN 0162-3257
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10803-021-05226-y

Immune activation during pregnancy exacerbates ASD-related alterations in Shank3-deficient mice.

Auteurs: Ekaterina Atanasova; Andrea Pérez Arévalo; Ines Graf; Rong Zhang; Juergen Bockmann; Anne-Kathrin Lutz; Tobias M. Boeckers
Publié dans: Mol Autism, Numéro 1, 2023, ISSN 2040-2392
Éditeur: BioMed Central
DOI: 10.1186/s13229-022-00532-3

The Link between Autism and Sex-Related Neuroanatomy, and Associated Cognition and Gene Expression

Auteurs: Floris DL, Peng H, Warrier V, Lombardo MV, Pretzsch CM, Moreau C, Tsompanidis A, Gong W, Mennes M, Llera A, van Rooij D, Oldehinkel M, Forde NJ, Charman T, Tillmann J, Banaschewski T, Moessnang C, Durston S, Holt RJ, Ecker C, Dell'Acqua F, Loth E, Bourgeron T, Murphy DGM, Marquand AF, Lai MC, Buitelaar JK, Baron-Cohen S, Beckmann CF; APEX Group; EU-AIMS LEAP Group.
Publié dans: Am J Psychiatry, Numéro 2022 Nov 23, 2022, ISSN 0002-953X
Éditeur: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220194

Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders.

Auteurs: Garrido D, Beretta S, Grabrucker S, Bauer HF, Bayer D, Sala C, Verpelli C, Roselli F, Bockmann J, Proepper C, Catanese A, Boeckers TM.
Publié dans: Mol Psychiatry, Numéro 2022 Dec;27(12), 2022, Page(s) 4994-5006, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-022-01756-8

The gut microbiome as mediator between diet and its impact on immune function

Auteurs: Shi H, Ter Horst R, Nielen S, Bloemendaal M, Jaeger M, Joosten I, Koenen H, Joosten LAB, Schweren LJS, Vasquez AA, Netea MG, Buitelaar J
Publié dans: Sci Rep, Numéro 2022 Mar 25;12(1), 2022, Page(s) 5149, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-08544-y

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