Comorbid Analysis of Neurodevelopmental Disorders and Epilepsy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Report on developmental trajectories in PTCHD1 genetic mouse model

Report on developmental trajectories of co-morbidity phenotype expression in PTCHD1 genetic mouse model

Report on prototype of tablet based translational test battery for pre-schoolers

Prototype of tablet based translational test battery for pre-schoolers

Report on developmental trajectories in NRNX1 and SHANK3 genetic mouse models

Report on developmental trajectories of comorbidity phenotype expression in NRNX1 and SHANK3 genetic mouse models

Communication toolbox
Report on the critical developmental windows for treatment intervention

Report on the critical developmental windows for treatment intervention based on the expression of pathogenic pathways.

First collection of training materials
Internet-based discussion forum set up

Internetbased discussion forum set up

CANDY public website and social media channels

Publications

Autistic and nonautistic adolescents do not differ in adaptation to gaze direction

Auteurs: Emma K. Ward, Jan K. Buitelaar, Sabine Hunnius
Publié dans: Autism Research, Numéro 17, 2024, Page(s) 1001-1015, ISSN 1939-3806
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/aur.3118

Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms.

Auteurs: Joanna Szopinska-Tokov; Sarita Dam; Jilly Naaijen; Prokopis Konstanti; Nanda Rommelse; Clara Belzer; Jan Buitelaar; Barbara Franke; Mirjam Bloemendaal; Esther Aarts; Alejandro Arias Vasquez
Publié dans: Microorganisms, Numéro 3, 2020, ISSN 2076-2607
Éditeur: MDPI
DOI: 10.3390/microorganisms8030406

Cerebellar atypicalities in autism?

Auteurs: Charles Laidi; Dorothea L. Floris; Julian Tillmann; Yannis Elandaloussi; Mariam Zabihi; Tony Charman; Thomas Wolfers; Sarah Durston; Carolin Moessnang; Flavio Dell’Acqua; Christine Ecker; Eva Loth; Declan Murphy; Simon Baron-Cohen; Jan K. Buitelaar; Andre F. Marquand; Christian F. Beckmann; Vincent Frouin; Marion Leboyer; Edouard Duchesnay; Pierrick Coupé; Josselin Houenou; null Tobias Banasche
Publié dans: Biological Psychiatry, 92, 674 - 682, Numéro 3, 2022, ISSN 0006-3223
Éditeur: Elsevier BV
DOI: 10.1016/j.biopsych.2022.05.020

Global motion processing in infants’ visual cortex and the emergence of autism

Auteurs: Irzam Hardiansyah, Pär Nyström, Mark J. Taylor, Sven Bölte, Angelica Ronald, Terje Falck-Ytter
Publié dans: Communications Biology, Numéro 6, 2023, ISSN 2399-3642
Éditeur: Nature Portfolio
DOI: 10.1038/s42003-023-04707-3

Disrupted extracellular matrix and cell cycle genes in autism-associated Shank3 deficiency are targeted by lithium

Auteurs: Valentin Ioannidis, Rakshita Pandey, Helen Friedericke Bauer, Michael Schön, Jürgen Bockmann, Tobias M. Boeckers, Anne-Kathrin Lutz
Publié dans: Molecular Psychiatry, Numéro 29, 2024, Page(s) 704-717, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-023-02362-y

Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research

Auteurs: Na Cai, Brad Verhulst, Ole A. Andreassen, Jan Buitelaar, Howard J. Edenberg, John M. Hettema, Michael Gandal, Andrew Grotzinger, Katherine Jonas, Phil Lee, Travis T. Mallard, Manuel Mattheisen, Michael C. Neale, John I. Nurnberger, Wouter J. Peyrot, Elliot M. Tucker-Drob, Jordan W. Smoller, Kenneth S. Kendler
Publié dans: Molecular Psychiatry, Numéro 30, 2025, Page(s) 1627-1638, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-024-02878-x

Suppression of Cofilin function in the somatosensory cortex alters social contact behavior in the BTBR mouse inbred line

Auteurs: Iris W Riemersma, Kevin G O Ike, Thomas Sollie, Elroy L Meijer, Robbert Havekes, Martien J H Kas
Publié dans: Cerebral Cortex, Numéro 34, 2024, ISSN 1047-3211
Éditeur: Oxford University Press
DOI: 10.1093/cercor/bhae136

SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system

Auteurs: Mariagiovanna Malara; Anne-Kathrin Lutz; Berra Incearap; Helen Friedericke Bauer; Silvia Cursano; Katrin Volbracht; Joanna Janina Lerner; Rakshita Pandey; Jan Philipp Delling; Valentin Ioannidis; Andrea Pérez Arévalo; Jaime Eugenin von Bernhardi; Michael Schön; Jürgen Bockmann; Leda Dimou; Tobias M. Boeckers
Publié dans: Cell Mol Life Sci, Numéro 3, 2022, ISSN 1420-682X
Éditeur: Birkhauser Verlag
DOI: 10.1007/s00018-022-04400-4

Coordinated Cortical Thickness Alterations Across Six Neurodevelopmental and Psychiatric Disorders

Auteurs: Hettwer MD, Larivière S, Park BY, van den Heuvel OA, Schmaal L, Andreassen OA, Ching CRK, Hoogman M, Buitelaar J, van Rooij D, Veltman DJ, Stein DJ, Franke B, van Erp TGM; ENIGMA ADHD Working Group; ENIGMA Autism Working Group; ENIGMA Bipolar Disorder Working Group; ENIGMA Major Depression Working Group; ENIGMA OCD Working Group; ENIGMA Schizophrenia Working Group; Jahanshad N, Thompson PM, Thomo
Publié dans: Nat Commun, Numéro 2022 Nov 11;13(1), 2022, Page(s) 6851, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-34367-6

Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis

Auteurs: Maja Rudling, Pär Nyström, Sven Bölte, Terje Falck‐Ytter
Publié dans: Journal of Child Psychology and Psychiatry, 2021, ISSN 0021-9630
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.13520

Evaluation of data imputation strategies in complex, deeply-phenotyped data sets: the case of the EU-AIMS Longitudinal European Autism Project.

Auteurs: Llera, A; Brammer, M; Oakley, B; Tillmann, J; Zabihi, M; Amelink, J S; Mei, T; Charman, T; Ecker, C; Dell'Acqua, F; Banaschewski, T; Moessnang, C; Baron-Cohen, S; Holt, R; Durston, S; Murphy, D; Loth, E; Buitelaar, J K; Floris, D L; Beckmann, C F
Publié dans: BMC Med Res Methodol, Numéro 3, 2022, ISSN 1471-2288
Éditeur: BioMed Central
DOI: 10.1186/s12874-022-01656-z

Spatial and Temporal Gene Function Studies in Rodents: Towards Gene-Based Therapies for Autism Spectrum Disorder

Auteurs: Riemersma IW, Havekes R, Kas MJH
Publié dans: Genes, Numéro 2021 Dec 23;13(1), 2021, Page(s) 28, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13010028

Infant responses to direct gaze and associations to autism: A live eye-tracking study

Auteurs: Maja Rudling, Pär Nyström, Giorgia Bussu, Sven Bölte, Terje Falck-Ytter
Publié dans: Autism, Numéro 28, 2024, Page(s) 1677-1689, ISSN 1362-3613
Éditeur: SAGE Publications
DOI: 10.1177/13623613231203037

Age-related brain deviations and aggression

Auteurs: Holz NE, Floris DL, Llera A, Aggensteiner PM, Kia SM, Wolfers T, Baumeister S, Böttinger B, Glennon JC, Hoekstra PJ, Dietrich A, Saam MC, Schulze UME, Lythgoe DJ, Williams SCR, Santosh P, Rosa-Justicia M, Bargallo N, Castro-Fornieles J, Arango C, Penzol MJ, Walitza S, Meyer-Lindenberg A, Zwiers M, Franke B, Buitelaar J, Naaijen J, Brandeis D, Beckmann C, Banaschewski T, Marquand AF.
Publié dans: Psychol Med, Numéro 2022 Apr 22, 2022, Page(s) 1-10, ISSN 0033-2917
Éditeur: Cambridge University Press
DOI: 10.1017/s003329172200068x

Neurobiological Correlates of Change in Adaptive Behavior in Autism

Auteurs: Pretzsch CM, Schäfer T, Lombardo MV, Warrier V, Mann C, Bletsch A, Chatham CH, Floris DL, Tillmann J, Yousaf A, Jones E, […] Beckmann CF, Banaschewski T, Durston S, Freitag CM; EU-AIMS LEAP Group; Murphy DGM, Ecker C..
Publié dans: Am J Psychiatry, Numéro 2022 May;179(5), 2022, Page(s) 336-349, ISSN 0002-953X
Éditeur: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.21070711

What are you looking at? Gaze following with and without target objects in ASD and typical development.

Auteurs: Thorup E, Nyström P, Bölte S, Falck-Ytter T
Publié dans: Autism, Numéro 2022 Oct;26(7), 2022, Page(s) 1668-1680, ISSN 1362-3613
Éditeur: SAGE Publications
DOI: 10.1177/13623613211061940

Gray matter covariations in autism: out-of-sample replication using the ENIGMA autism cohort

Auteurs: Ting Mei, Alberto Llera, Natalie J. Forde, Daan van Rooij, Dorothea L. Floris, Christian F. Beckmann, Jan K. Buitelaar
Publié dans: Molecular Autism, Numéro 15, 2024, ISSN 2040-2392
Éditeur: BioMed Central
DOI: 10.1186/s13229-024-00583-8

Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review

Auteurs: Tamouza R, Volt F, Richard JR, Wu CL, Bouassida J, Boukouaci W, Lansiaux P, Cappelli B, Scigliuolo GM, Rafii H, Kenzey C, Mezouad E, Naamoune S, Chami L, Lejuste F, Farge D, Gluckman E
Publié dans: Front Cell Dev Biol., Numéro 2022 Jul 5;10, 2022, ISSN 1662-5099
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fcell.2022.809686

From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans.

Auteurs: Ahmad J, Ellis C, Leech R, Voytek B, Garces P, Jones E, Buitelaar J, Loth E, Dos Santos FP, Amil AF, Verschure PFMJ, Murphy D, McAlonan G
Publié dans: Transl Psychiatry., Numéro 2022 Nov 8;12(1):, 2022, Page(s) 467, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-022-02218-z

Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology

Auteurs: Mei T, Forde NJ, Floris DL, Dell'Acqua F, Stones R, Ilioska I, Durston S, Moessnang C, Banaschewski T, Holt RJ, Baron-Cohen S, Rausch A, Loth E, Oakley B, Charman T, Ecker C, Murphy DGM; EU-AIMS LEAP group; Beckmann CF, Llera A, Buitelaar JK.
Publié dans: Biol Psychiatry Cogn Neurosci Neuroimaging, Numéro 2022 Sep 6:S2451-9022(22), 2022, Page(s) 00212-9, ISSN 2451-9022
Éditeur: Elsevier Inc. Al
DOI: 10.1016/j.bpsc.2022.08.011

Expression profiles of the autism-related SHANK proteins in the human brain

Auteurs: Sarah Woelfle, Maria T. Pedro, Jan Wagner, Michael Schön, Tobias M. Boeckers
Publié dans: BMC Biology, Numéro 21, 2023, ISSN 1741-7007
Éditeur: BioMed Central
DOI: 10.1186/s12915-023-01712-0

Large‐scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents

Auteurs: F. Kurth, D. Schijven, O. A. van den Heuvel, M. Hoogman, D. van Rooij, D. J. Stein, J. K. Buitelaar, S. Bölte, G. Auzias, A. Kushki, G. Venkatasubramanian, K. Rubia, S. Bollmann, J. Isaksson, F. Jaspers‐Fayer, R. Marsh, M. C. Batistuzzo, P. D. Arnold, R. A. Bressan, S. E. Stewart, P. Gruner, L. Sorensen, P. M. Pan, T. J. Silk, R. C. Gur, A. I. Cubillo, J. Haavik, R. L. O'Gorman Tuura, C. A. Har
Publié dans: Human Brain Mapping, Numéro 45, 2025, ISSN 1065-9471
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/hbm.26754

Brain‐age prediction: Systematic evaluation of site effects, and sample age range and size

Auteurs: Yuetong Yu, Hao‐Qi Cui, Shalaila S. Haas, Faye New, Nicole Sanford, Kevin Yu, Denghuang Zhan, Guoyuan Yang, Jia‐Hong Gao, Dongtao Wei, Jiang Qiu, Nerisa Banaj, Dorret I. Boomsma, Alan Breier, Henry Brodaty, Randy L. Buckner, Jan K. Buitelaar, Dara M. Cannon, Xavier Caseras, Vincent P. Clark, Patricia J. Conrod, Fabrice Crivello, Eveline A. Crone, Udo Dannlowski, Christopher G. Davey, Lieuwe de
Publié dans: Human Brain Mapping, Numéro 45, 2024, ISSN 1065-9471
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/hbm.26768

SHANK3 Antibody Validation: Differential Performance in Western Blotting, Immunocyto- and Immunohistochemistry.

Auteurs: Anne-Kathrin Lutz; Helen Friedericke Bauer; Valentin Ioannidis; Michael Schön; Tobias M. Boeckers
Publié dans: Front Synaptic Neurosci ., Numéro 3, 2022, ISSN 1663-3563
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnsyn.2022.890231

The breakdown of social looking

Auteurs: Terje Falck-Ytter
Publié dans: Neuroscience & Biobehavioral Reviews, Numéro 161, 2024, Page(s) 105689, ISSN 0149-7634
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2024.105689

Development of sex- and genotype-specific behavioral phenotypes in a Shank3 mouse model for neurodevelopmental disorders

Auteurs: Helen Friedericke Bauer, Jan Philipp Delling, Jürgen Bockmann, Tobias M. Boeckers, Michael Schön
Publié dans: Frontiers in Behavioral Neuroscience, Numéro 16, 2023, ISSN 1662-5153
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2022.1051175

Phenotypic effects of genetic variants associated with autism

Auteurs: Thomas Rolland, Freddy Cliquet, Richard J. L. Anney, Clara Moreau, Nicolas Traut, Alexandre Mathieu, Guillaume Huguet, Jinjie Duan, Varun Warrier, Swan Portalier, Louise Dry, Claire S. Leblond, Elise Douard, Frédérique Amsellem, Simon Malesys, Anna Maruani, Roberto Toro, Anders D. Børglum, Jakob Grove, Simon Baron-Cohen, Alan Packer, Wendy K. Chung, Sébastien Jacquemont, Richard Delorme, Thoma
Publié dans: Nature Medicine, Numéro 29, 2023, Page(s) 1671-1680, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-023-02408-2

Auteurs: Berra Yildiz, Lisa Schiedt, Medhanie Mulaw, Jürgen Bockmann, Sarah Jesse, Anne-Kathrin Lutz, Tobias M. Boeckers
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 11, 2023, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2023.1243299

Patterns of connectome variability in autism across five functional activation tasks: findings from the LEAP project

Auteurs: Looden T, Floris DL, Llera A, Chauvin RJ, Charman T, Banaschewski T, Murphy D, Marquand AF, Buitelaar JK, Beckmann CF; AIMS-2-TRIALS group
Publié dans: Mol Autism, Numéro 2022 Dec 27;13(1), 2022, Page(s) 53, ISSN 2040-2392
Éditeur: BioMed Central
DOI: 10.1186/s13229-022-00529

Cross-sectional and longitudinal neuroanatomical profiles of distinct clinical (adaptive) outcomes in autism

Auteurs: Charlotte M. Pretzsch, Dorothea L. Floris, Tim Schäfer, Anke Bletsch, Caroline Gurr, Michael V. Lombardo, Chris H. Chatham, Julian Tillmann, Tony Charman, Martina Arenella, Emily Jones, Sara Ambrosino, Thomas Bourgeron, Guillaume Dumas, Freddy Cliquet, Claire S. Leblond, Eva Loth, Bethany Oakley, Jan K. Buitelaar, Simon Baron-Cohen, Christian F. Beckmann, Antonio M. Persico, Tobias Banaschewski,
Publié dans: Molecular Psychiatry, Numéro 28, 2023, Page(s) 2158-2169, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-023-02016-z

A multimodal neural signature of face processing in autism within the fusiform gyrus

Auteurs: Dorothea L. Floris, Alberto Llera, Mariam Zabihi, Carolin Moessnang, Emily J. H. Jones, Luke Mason, Rianne Haartsen, Nathalie E. Holz, Ting Mei, Camille Elleaume, Bruno Hebling Vieira, Charlotte M. Pretzsch, Natalie J. Forde, Sarah Baumeister, Flavio Dell’Acqua, Sarah Durston, Tobias Banaschewski, Christine Ecker, Rosemary J. Holt, Simon Baron-Cohen, Thomas Bourgeron, Tony Charman, Eva Loth, Dec
Publié dans: Nature Mental Health, Numéro 3, 2025, Page(s) 31-45, ISSN 2731-6076
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s44220-024-00349-4

Qualitative differences in the spatiotemporal brain states supporting configural face processing emerge in adolescence in autism

Auteurs: Haartsen R, Mason L, Garces P, Gui A, Charman T, Tillmann J, Johnson MH, Buitelaar JK, Loth E, Murphy D, Jones EJH; EU-AIMS LEAP group.
Publié dans: Cortex, Numéro 2022 Oct;155, 2022, Page(s) 13-29, ISSN 0010-9452
Éditeur: Masson Publishing
DOI: 10.1016/j.cortex.2022.06.010

Local Molecular and Global Connectomic Contributions to Cross-Disorder Cortical Abnormalities

Auteurs: Hansen JY, Shafiei G, Vogel JW, Smart K, Bearden CE, Hoogman M, Franke B, van Rooij D, Buitelaar J, McDonald CR, Sisodiya SM, Schmaal L, Veltman DJ, van den Heuvel OA, Stein DJ, van Erp TGM, Ching CRK, Andreassen OA, Hajek T, Opel N, Modinos G, Aleman A, van der Werf Y, Jahanshad N, Thomopoulos SI, Thompson PM, Carson RE, Dagher A, Misic B.
Publié dans: Nat Commun, Numéro 2022 Aug 10;13(1):, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-32420-y

Pre‐pragmatic language use in toddlerhood: Developmental antecedents, aetiological factors, and associations to autism

Auteurs: Maja Rudling, Ana Maria Portugal, Sven Bölte, Terje Falck‐Ytter
Publié dans: JCPP Advances, Numéro 3, 2023, ISSN 2692-9384
Éditeur: Wiley-Blackwell
DOI: 10.1002/jcv2.12135

Does the current state of biomarker discovery in autism reflect the limits of reductionism in precision medicine? Suggestions for an integrative approach that considers dynamic mechanisms between brain, body, and the social environment

Auteurs: Eva Loth
Publié dans: Frontiers in Psychiatry, Numéro 14, 2023, ISSN 1664-0640
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2023.1085445

Attention-deficit/hyperactivity disorder

Auteurs: Stephen V. Faraone, Mark A. Bellgrove, Isabell Brikell, Samuele Cortese, Catharina A. Hartman, Chris Hollis, Jeffrey H. Newcorn, Alexandra Philipsen, Guilherme V. Polanczyk, Katya Rubia, Margaret H. Sibley, Jan K. Buitelaar
Publié dans: Nature Reviews Disease Primers, Numéro 10, 2024, ISSN 2056-676X
Éditeur: Nature Portfolio
DOI: 10.1038/s41572-024-00495-0

SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(−/−) Mice

Auteurs: Lutz, Anne-Kathrin; Pérez Arévalo, Andrea; Ioannidis, Valentin; Stirmlinger, Nadine; Demestre, Maria; Delorme, Richard; Bourgeron, Thomas; Boeckers, Tobias M.
Publié dans: Frontiers in Molecular Neuroscience, Numéro 3, 2021, ISSN 1662-5099
Éditeur: Frontiers Research Foundation
DOI: 10.18725/oparu-40117

Less frequent face looking in infancy is related to autism likelihood status but not diagnosis: A study of parent-infant interaction

Auteurs: Emilia Thorup, Sven Bölte, Terje Falck-Ytter
Publié dans: Research in Autism Spectrum Disorders, Numéro 115, 2024, Page(s) 102422, ISSN 1750-9467
Éditeur: Elsevier BV
DOI: 10.1016/j.rasd.2024.102422

Tracing the paths: a systematic review of mediators of complex trauma and complex post-traumatic stress disorder

Auteurs: Joseph Harris, Eva Loth, Vaheshta Sethna
Publié dans: Frontiers in Psychiatry, Numéro 15, 2024, ISSN 1664-0640
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2024.1331256

How 18-month-olds with Later Autism Look at Other Children Interacting: The Timing of Gaze Allocation

Auteurs: Charlotte Viktorsson, Sven Bölte, Terje Falck-Ytter
Publié dans: Journal of Autism and Developmental Disorders, 2023, ISSN 0162-3257
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10803-023-06118-z

Structural models of genome-wide covariance identify multiple common dimensions in autism

Auteurs: Lucía de Hoyos, Maria T. Barendse, Fenja Schlag, Marjolein M. J. van Donkelaar, Ellen Verhoef, Chin Yang Shapland, Alexander Klassmann, Jan Buitelaar, Brad Verhulst, Simon E. Fisher, Dheeraj Rai, Beate St Pourcain
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-46128-8

Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications

Auteurs: Delling JP, Boeckers TM
Publié dans: J Neurodev Disord, Numéro 2021 Nov 16;13(1), 2021, Page(s) 55, ISSN 1866-1955
Éditeur: Springer Nature
DOI: 10.1186/s11689-021-09397-8

Decomposing the Brain in Autism: Linking Behavioral Domains to Neuroanatomical Variation and Genomic Underpinnings

Auteurs: Hanna Seelemeyer, Caroline Gurr, Johanna Leyhausen, Lisa M. Berg, Charlotte M. Pretzsch, Tim Schäfer, Bassem Hermila, Christine M. Freitag, Eva Loth, Bethany Oakley, Luke Mason, Jan K. Buitelaar, Christian F. Beckmann, Dorothea L. Floris, Tony Charman, Tobias Banaschewski, Emily Jones, Thomas Bourgeron, Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Tobias Banaschewski, Simon Baron-Cohen, Sarah Ba
Publié dans: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2025, ISSN 2451-9022
Éditeur: Elsevier BV
DOI: 10.1016/j.bpsc.2024.12.003

Deletion of the Autism-Associated Protein SHANK3 Abolishes Structural Synaptic Plasticity after Brain Trauma.

Auteurs: Urrutia-Ruiz, Carolina; Rombach, Daniel; Cursano, Silvia; Gerlach-Arbeiter, Susanne; Schoen, Michael; Bockmann, Juergen; Demestre, Maria; Boeckers, Tobias M.; Pérez-Mediavilla, Alberto
Publié dans: International Journal of Molecular Sciences; Volume 23; Numéro 11; Pages: 6081, Numéro 3, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23116081

Low-grade inflammation as mediator between diet and behavioral disinhibition: A UK Biobank study.

Auteurs: Shi H, Schweren LJS, Ter Horst R, Bloemendaal M, van Rooij D, Vasquez AA, Hartman CA, Buitelaar JK
Publié dans: Brain Behav Immun, Numéro 2022 Nov;106, 2022, Page(s) 100-110., ISSN 0889-1591
Éditeur: Academic Press
DOI: 10.1016/j.bbi.2022.07.165

Connectome-wide Mega-analysis Reveals Robust Patterns of Atypical Functional Connectivity in Autism

Auteurs: Iva Ilioska, Marianne Oldehinkel, Alberto Llera, Sidhant Chopra, Tristan Looden, Roselyne Chauvin, Daan Van Rooij, Dorothea L. Floris, Julian Tillmann, Carolin Moessnang, Tobias Banaschewski, Rosemary J. Holt, Eva Loth, Tony Charman, Declan G.M. Murphy, Christine Ecker, Maarten Mennes, Christian F. Beckmann, Alex Fornito, Jan K. Buitelaar
Publié dans: Biological Psychiatry, Numéro 94, 2023, Page(s) 29-39, ISSN 0006-3223
Éditeur: Elsevier BV
DOI: 10.1016/j.biopsych.2022.12.018

The future of child and adolescent clinical psychopharmacology: A systematic review of phase 2, 3, or 4 randomized controlled trials of pharmacologic agents without regulatory approval or for unapproved indications

Auteurs: Samuele Cortese, Katherine McGinn, Mikkel Højlund, Alan Apter, Celso Arango, Immaculada Baeza, Tobias Banaschewski, Jan Buitelaar, Josefina Castro-Fornieles, David Coghill, David Cohen, Edna Grünblatt, Pieter J. Hoekstra, Anthony James, Pia Jeppesen, Péter Nagy, Anne Katrine Pagsberg, Mara Parellada, Antonio M. Persico, Diane Purper-Ouakil, Veit Roessner, Paramala Santosh, Emily Simonoff, Dejan
Publié dans: Neuroscience & Biobehavioral Reviews, Numéro 149, 2023, Page(s) 105149, ISSN 0149-7634
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2023.105149

Parental Experiences with Early Identification and Initial Care for their Child with Autism: Tailored Improvement Strategies

Auteurs: Snijder MIJ, Langerak IPC, Kaijadoe SPT, Buruma ME, Verschuur R, Dietz C, Buitelaar JK, Oosterling IJ. J
Publié dans: Autism Dev Disord., Numéro 2022 Aug;52(8), 2022, ISSN 0162-3257
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10803-021-05226-y

The sensory-first account of autism

Auteurs: Terje Falck-Ytter, Giorgia Bussu
Publié dans: Neuroscience & Biobehavioral Reviews, Numéro 153, 2024, Page(s) 105405, ISSN 0149-7634
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2023.105405

A Genetic Bridge Between Medicine and Neurodiversity for Autism

Auteurs: Claire S. Leblond, Thomas Rolland, Eli Barthome, Zakaria Mougin, Mathis Fleury, Christine Ecker, Stéf Bonnot-Briey, Freddy Cliquet, Anne-Claude Tabet, Anna Maruani, Boris Chaumette, Jonathan Green, Richard Delorme, Thomas Bourgeron
Publié dans: Annual Review of Genetics, Numéro 58, 2024, Page(s) 487-512, ISSN 0066-4197
Éditeur: Annual Reviews, Inc.
DOI: 10.1146/annurev-genet-111523-102614

Fine-grained topographic organization within somatosensory cortex during resting-state and emotional face-matching task and its association with ASD traits

Auteurs: Christina Isakoglou, Koen V. Haak, Thomas Wolfers, Dorothea L. Floris, Alberto Llera, Marianne Oldehinkel, Natalie J. Forde, Bethany F. M. Oakley, Julian Tillmann, Rosemary J. Holt, Carolin Moessnang, Eva Loth, Thomas Bourgeron, Simon Baron-Cohen, Tony Charman, Tobias Banaschewski, Declan G. M. Murphy, Jan K. Buitelaar, Andre F. Marquand, Christian F. Beckmann
Publié dans: Translational Psychiatry, Numéro 13, 2023, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-023-02559-3

Agomelatine in pediatric patients with moderate to severe major depressive disorder: an open-label extension study

Auteurs: Celso Arango, Joerg M. Fegert, Françoise Picarel-Blanchot, Ute Marx, Lucie Truffaut-Chalet, Pierre-François Pénélaud, Jan Buitelaar, null null
Publié dans: European Child & Adolescent Psychiatry, Numéro 34, 2025, Page(s) 1603-1614, ISSN 1018-8827
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00787-024-02587-4

Immune activation during pregnancy exacerbates ASD-related alterations in Shank3-deficient mice.

Auteurs: Ekaterina Atanasova; Andrea Pérez Arévalo; Ines Graf; Rong Zhang; Juergen Bockmann; Anne-Kathrin Lutz; Tobias M. Boeckers
Publié dans: Mol Autism, Numéro 1, 2023, ISSN 2040-2392
Éditeur: BioMed Central
DOI: 10.1186/s13229-022-00532-3

Family history of ADHD associates with stronger problem‐solving skills amongst 2‐ to 3‐year‐olds

Auteurs: Alexandra Hendry, Emily J. H. Jones, Linn Andersson‐Konke, Mary Agyapong, Tessel Bazelmans, Jannath Begum‐Ali, Mutluhan Ersoy, Amy Goodwin, Greg Pasco, Terje Falck‐Ytter, Mark H. Johnson, Tony Charman, null null
Publié dans: JCPP Advances, 2025, ISSN 2692-9384
Éditeur: Wiley
DOI: 10.1002/jcv2.70009

Dissecting the 22q13 region to explore the genetic and phenotypic diversity of patients with Phelan-McDermid syndrome

Auteurs: Aline Vitrac, Claire S. Leblond, Thomas Rolland, Freddy Cliquet, Alexandre Mathieu, Anna Maruani, Richard Delorme, Michael Schön, Andreas M. Grabrucker, Conny van Ravenswaaij-Arts, Katy Phelan, Anne-Claude Tabet, Thomas Bourgeron
Publié dans: European Journal of Medical Genetics, Numéro 66, 2023, Page(s) 104732, ISSN 1769-7212
Éditeur: Elsevier BV
DOI: 10.1016/j.ejmg.2023.104732

A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders

Auteurs: Laura Lombardi, Sigrid Le Clerc, Ching-Lien Wu, Jihène Bouassida, Wahid Boukouaci, Sobika Sugusabesan, Jean-Romain Richard, Mohamed Lajnef, Maxime Tison, Philippe Le Corvoisier, Caroline Barau, Tobias Banaschewski, Rosemary Holt, Sarah Durston, Antonio M. Persico, Bethany Oakley, Eva Loth, Jan Buitelaar, Declan Murphy, Marion Leboyer, Jean-François Zagury, Ryad Tamouza
Publié dans: Translational Psychiatry, Numéro 13, 2023, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-023-02550-y

Combined expansion and STED microscopy reveals altered fingerprints of postsynaptic nanostructure across brain regions in ASD-related SHANK3-deficiency

Auteurs: Jan Philipp Delling, Helen Friedericke Bauer, Susanne Gerlach-Arbeiter, Michael Schön, Christian Jacob, Jan Wagner, Maria Teresa Pedro, Bernd Knöll, Tobias M. Boeckers
Publié dans: Molecular Psychiatry, 2024, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-024-02559-9

Different sensory dimensions in infancy are associated with separable etiological influences and with autistic traits in toddlerhood

Auteurs: Giorgia Bussu, Ana Maria Portugal, Terje Falck‐Ytter
Publié dans: Journal of Child Psychology and Psychiatry, Numéro 66, 2025, Page(s) 1182-1196, ISSN 0021-9630
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.14143

A stable and replicable neural signature of lifespan adversity in the adult brain

Auteurs: Nathalie E. Holz, Mariam Zabihi, Seyed Mostafa Kia, Maximillian Monninger, Pascal-M. Aggensteiner, Sebastian Siehl, Dorothea L. Floris, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Mich
Publié dans: Nature Neuroscience, Numéro 26, 2023, Page(s) 1603-1612, ISSN 1097-6256
Éditeur: Nature Publishing Group
DOI: 10.1038/s41593-023-01410-8

Seven unique frequency profiles for scoring vigilance states in preclinical electrophysiological data

Auteurs: Freja Gam Østergaard, Martien J. H. Kas
Publié dans: Frontiers in Neuroscience, Numéro 19, 2025, ISSN 1662-453X
Éditeur: Frontiers Media SA
DOI: 10.3389/fnins.2025.1488709

The Link between Autism and Sex-Related Neuroanatomy, and Associated Cognition and Gene Expression

Auteurs: Floris DL, Peng H, Warrier V, Lombardo MV, Pretzsch CM, Moreau C, Tsompanidis A, Gong W, Mennes M, Llera A, van Rooij D, Oldehinkel M, Forde NJ, Charman T, Tillmann J, Banaschewski T, Moessnang C, Durston S, Holt RJ, Ecker C, Dell'Acqua F, Loth E, Bourgeron T, Murphy DGM, Marquand AF, Lai MC, Buitelaar JK, Baron-Cohen S, Beckmann CF; APEX Group; EU-AIMS LEAP Group.
Publié dans: Am J Psychiatry, Numéro 2022 Nov 23, 2022, ISSN 0002-953X
Éditeur: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220194

Patterns of Brain Maturation in Autism and Their Molecular Associations

Auteurs: Charlotte M. Pretzsch, Martina Arenella, Jason P. Lerch, Michael V. Lombardo, Christian Beckmann, Tim Schaefer, Johanna Leyhausen, Caroline Gurr, Anke Bletsch, Lisa M. Berg, Hanna Seelemeyer, Dorothea L. Floris, Bethany Oakley, Eva Loth, Thomas Bourgeron, Tony Charman, Jan Buitelaar, Grainne McAlonan, Declan Murphy, Christine Ecker, null null, Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Tobias B
Publié dans: JAMA Psychiatry, Numéro 81, 2024, Page(s) 1253, ISSN 2168-622X
Éditeur: American Medical Association
DOI: 10.1001/jamapsychiatry.2024.3194

CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue

Auteurs: Sarah Woelfle, Dhruva Deshpande, Simone Feldengut, Heiko Braak, Kelly Del Tredici, Francesco Roselli, Karl Deisseroth, Jens Michaelis, Tobias M. Boeckers, Michael Schön
Publié dans: BMC Biology, Numéro 21, 2023, ISSN 1741-7007
Éditeur: BioMed Central
DOI: 10.1186/s12915-023-01582-6

Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders.

Auteurs: Garrido D, Beretta S, Grabrucker S, Bauer HF, Bayer D, Sala C, Verpelli C, Roselli F, Bockmann J, Proepper C, Catanese A, Boeckers TM.
Publié dans: Mol Psychiatry, Numéro 2022 Dec;27(12), 2022, Page(s) 4994-5006, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-022-01756-8

The gut microbiome as mediator between diet and its impact on immune function

Auteurs: Shi H, Ter Horst R, Nielen S, Bloemendaal M, Jaeger M, Joosten I, Koenen H, Joosten LAB, Schweren LJS, Vasquez AA, Netea MG, Buitelaar J
Publié dans: Sci Rep, Numéro 2022 Mar 25;12(1), 2022, Page(s) 5149, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-08544-y

Validation framework for in vivo digital measures

Auteurs: Szczepan W. Baran, Susan E. Bolin, Stefano Gaburro, Marcel M. van Gaalen, Megan R. LaFollette, Chang-Ning Liu, Sean Maguire, Lucas P. J. J. Noldus, Natalie Bratcher-Petersen, Brian R. Berridge
Publié dans: Frontiers in Toxicology, Numéro 6, 2025, ISSN 2673-3080
Éditeur: Frontiers Media SA
DOI: 10.3389/ftox.2024.1484895

Downregulation of the Autism Spectrum Disorder Gene <i>Shank2</i> Decreases Bone Mass in Male Mice

Auteurs: Mubashir Ahmad, Nadine Stirmlinger, Irfana Jan, Ulrich Stifel, Sooyeon Lee, Marcel Weingandt, Ulrike Kelp, Jürgen Bockmann, Anita Ignatius, Tobias M. Böckers, Jan Tuckermann
Publié dans: JBMR Plus, Numéro 7, 2024, ISSN 2473-4039
Éditeur: Oxford Academic
DOI: 10.1002/jbm4.10711

Fast annotation of rodent behaviors with AI assistance: Human observer and SmartAnnotator collaborate through active learning.

Auteurs: Dam, E.A. van; Daniels, T.J.; Ottink, L.; van Gerven, M.A.J.; Noldus, L.P.J.J.
Publié dans: Proceedings of Measuring Behavior 2024, 13th International Conference on Methods and Techniques in Behavioral Research (Aberdeen, UK, 15-17 May 2024), 230-235., 2024
Éditeur: Proceedings of Measuring Behavior

Fast annotation of rodent behaviors with AI assistance: Human observer and SmartAnnotator collaborate through active learning

Auteurs: Dam, E.A. van; Daniels, T.J.; Ottink, L.; van Gerven, M.A.J.; Noldus, L.P.J.J.
Publié dans: Proceedings of Measuring Behavior, 2024
Éditeur: Proceedings of Measuring Behavior
DOI: 10.6084/m9.figshare.25897855

Making sense of autism

Auteurs: null null, Iris Riemersma
Publié dans: 2024
Éditeur: University of Groningen Press
DOI: 10.33612/diss.935803086

Machine Learning Strategies, Behavioral Challenges and Practical Solutions

Auteurs: Elsbeth van Dam
Publié dans: 2025
Éditeur: Radboud University Press
DOI: 10.54195/9789465150864

Making sense of autism: The role of synaptic dysfunction in shaping sensory trajectories

Auteurs: Iris W Riemersma
Publié dans: 2024
Éditeur: Groningen University

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