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Immune profiling to guide host-directed interventions to cure HBV infections

Project description

Host-directed interventions to cure hepatitis B infections

The objective of the EU-funded IP-cure-B project is to develop novel curative concepts for chronic hepatitis B (CHB). The project aims to improve the cure rate of CHB by boosting innate immunity with immune modulators and stimulating adaptive immune responses with a novel therapeutic vaccine. Researchers will also identify immune and viral biomarkers for patient stratification and treatment response monitoring. Integration of biological and clinical data will enable models for the best combination treatment and effectiveness of novel curative therapies with respect to disease spectrum and patient heterogeneity. The preclinical platform will be evaluated in humanised mice, combining immune-modulatory strategies to stimulate innate immunity, rescue exhausted HBV-specific T cells and generate anti-HBV adaptive responses. Proof of concept will be obtained in a clinical trial of a combination of novel compounds stimulating innate immunity.

Call for proposal

H2020-SC1-2019-Two-Stage-RTD
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Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 4 094 578

Participants (13)

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Switzerland
EU contribution
€ 690 048
Address
Rue Du Bugnon 21
1011 Lausanne
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 299 550
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
INSTITUT PASTEUR
France
EU contribution
€ 1 593 800
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
UNIVERSITA DEGLI STUDI DI PARMA
Italy
EU contribution
€ 1 030 053
Address
Via Universita 12
43100 Parma
Activity type
Higher or Secondary Education Establishments
FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO
Italy
EU contribution
€ 250 000
Address
Via Francesco Sforza 28
20122 Milano
Activity type
Other
UNIVERSITAETSKLINIKUM FREIBURG
Germany
EU contribution
€ 850 000
Address
Hugstetter Strasse 49
79106 Freiburg
Activity type
Higher or Secondary Education Establishments
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 250 000
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
EU contribution
€ 250 000
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona
Activity type
Research Organisations
GILEAD SCIENCES INC
United States
EU contribution
€ 0
Address
Lakeside Drive 333
94404 Foster City Ca
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SPRING BANK PHARMACEUTICALS INC.
United States
EU contribution
€ 0
Address
Corporation Trust Center 1209 Orange St
19801 Wilmington
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EUROPEAN LIVER PATIENTS ASSOCIATION
Belgium
EU contribution
€ 175 000
Address
Rue De La Loi 235/27
1040 Bruxelles
Activity type
Other
INSERM TRANSFERT SA
France
EU contribution
€ 300 000
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HOSPICES CIVILS DE LYON
France
EU contribution
€ 200 000
Address
Quai Des Celestins 3
69002 Lyon
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)