Skip to main content

Immune profiling to guide host-directed interventions to cure HBV infections

Project description

Host-directed interventions to cure hepatitis B infections

The objective of the EU-funded IP-cure-B project is to develop novel curative concepts for chronic hepatitis B (CHB). The project aims to improve the cure rate of CHB by boosting innate immunity with immune modulators and stimulating adaptive immune responses with a novel therapeutic vaccine. Researchers will also identify immune and viral biomarkers for patient stratification and treatment response monitoring. Integration of biological and clinical data will enable models for the best combination treatment and effectiveness of novel curative therapies with respect to disease spectrum and patient heterogeneity. The preclinical platform will be evaluated in humanised mice, combining immune-modulatory strategies to stimulate innate immunity, rescue exhausted HBV-specific T cells and generate anti-HBV adaptive responses. Proof of concept will be obtained in a clinical trial of a combination of novel compounds stimulating innate immunity.

Call for proposal

H2020-SC1-BHC-2018-2020

See other projects for this call

Sub call

H2020-SC1-2019-Two-Stage-RTD

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution
€ 3 992 425,50
Address
Rue De Tolbiac 101
75654 Paris
France

See on map

Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (15)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITE GRENOBLE ALPES
France
Net EU contribution
€ 15 027,50
Address
621 Avenue Centrale
38058 Grenoble

See on map

Region
Auvergne-Rhône-Alpes Rhône-Alpes Isère
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

CHU HOPITAUX DE BORDEAUX
France
Net EU contribution
€ 87 125,00
Address
Rue Dubernat 12
33404 Talence

See on map

Region
Nouvelle-Aquitaine Aquitaine Gironde
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Switzerland
Net EU contribution
€ 690 048,00
Address
Rue Du Bugnon 21
1011 Lausanne

See on map

Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,75
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 299 550,00
Address
Nobels Vag 5
17177 Stockholm

See on map

Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUT PASTEUR
France
Net EU contribution
€ 1 593 800,00
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15

See on map

Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI PARMA
Italy
Net EU contribution
€ 970 053,00
Address
Via Universita 12
43100 Parma

See on map

Region
Nord-Est Emilia-Romagna Parma
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,75
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

AZIENDA OSPEDALIERO-UNIVERSITARIA DI PARMA
Italy
Net EU contribution
€ 60 000,00
Address
Via Gramsci 14
43100 Parma

See on map

Region
Nord-Est Emilia-Romagna Parma
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO
Italy
Net EU contribution
€ 250 000,00
Address
Via Francesco Sforza 28
20122 Milano

See on map

Region
Nord-Ovest Lombardia Milano
Activity type
Other
Non-EU contribution
€ 0,00
UNIVERSITAETSKLINIKUM FREIBURG
Germany
Net EU contribution
€ 850 000,00
Address
Hugstetter Strasse 49
79106 Freiburg

See on map

Region
Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
Net EU contribution
€ 250 000,00
Address
6 Christou Lada Str
10561 Athina

See on map

Region
Κεντρικός Τομέας Αθηνών Aττική Αττική
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
Net EU contribution
€ 250 000,00
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona

See on map

Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
GILEAD SCIENCES INC
United States
Net EU contribution
€ 0,00
Address
Lakeside Drive 333
94404 Foster City Ca

See on map

Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 360 000,00
EUROPEAN LIVER PATIENTS ASSOCIATION
Belgium
Net EU contribution
€ 175 000,00
Address
Rue De La Loi 235/27
1040 Bruxelles

See on map

Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Other
Non-EU contribution
€ 0,00
INSERM TRANSFERT SA
France
Net EU contribution
€ 300 000,00
Address
Rue Watt 7
75013 Paris

See on map

Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
HOSPICES CIVILS DE LYON
France
Net EU contribution
€ 200 000,00
Address
Quai Des Celestins 3
69002 Lyon

See on map

Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00