Project description
Host-directed interventions to cure hepatitis B infections
The objective of the EU-funded IP-cure-B project is to develop novel curative concepts for chronic hepatitis B (CHB). The project aims to improve the cure rate of CHB by boosting innate immunity with immune modulators and stimulating adaptive immune responses with a novel therapeutic vaccine. Researchers will also identify immune and viral biomarkers for patient stratification and treatment response monitoring. Integration of biological and clinical data will enable models for the best combination treatment and effectiveness of novel curative therapies with respect to disease spectrum and patient heterogeneity. The preclinical platform will be evaluated in humanised mice, combining immune-modulatory strategies to stimulate innate immunity, rescue exhausted HBV-specific T cells and generate anti-HBV adaptive responses. Proof of concept will be obtained in a clinical trial of a combination of novel compounds stimulating innate immunity.
Fields of science
- medical and health scienceshealth sciencespublic health
- natural sciencesbiological sciencesgeneticsmutationvirus mutation
- medical and health scienceshealth sciencesinfectious diseasesDNA viruseshepatitis B
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
75654 Paris
France
See on map
Participants (15)
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
38058 Grenoble
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
33404 Talence
See on map
1011 Lausanne
See on map
17177 Stockholm
See on map
75724 Paris Cedex 15
See on map
43100 Parma
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
43100 Parma
See on map
20122 Milano
See on map
79106 Freiburg
See on map
10561 Athina
See on map
08035 Barcelona
See on map
94404 Foster City Ca
See on map
1040 Bruxelles
See on map
75013 Paris
See on map
69002 Lyon
See on map