Associative mechanisms linking a defective minipuberty to the appearance of mental and nonmental disorders: infantile NO replenishment as a new therapeutic possibility

Información del proyecto

miniNO

Identificador del acuerdo de subvención: 847941

DOI

10.3030/847941

Fecha de la firma de la CE 5 Diciembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Octubre 2026

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 6 487 770,00

Aportación de la UE

€ 6 487 770,00

Coordinado por

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

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Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Other (1)

Novel transgenic mouse model

Websites, patent fillings, videos etc. (1)

Project website and communication tools

Project visual identity: Logo, templates, .... and project leaflet

Publicaciones

Peer reviewed articles (18)

Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra's seminal work

Autores: Greg M Anderson, Jennifer W Hill, Ursula B Kaiser, Victor M Navarro, Ken K Ong , John R B Perry, Vincent Prevot, Manuel Tena-Sempere, Carol F Elias
Publicado en: Nature Review Endocrinology, 2024, ISSN 1759-5037
Editor: Nature
DOI: 10.1038/s41574-023-00919-z

Dominant monoallelic variant in the PAK2 gene causes Knobloch syndrome type 2

Autores: Stylianos E Antonarakis, Ales Holoubek, Melivoia Rapti, Jesse Rademaker, Jenny Meylan, Justyna Iwaszkiewicz, Vincent Zoete, Callum Wilson, Juliet Taylor, Muhammad Ansar, Christelle Borel, Olivier Menzel, Kateřina Kuželová, Federico A Santoni
Publicado en: Human Molecular Genetics, 2021, Página(s) in press, ISSN 0964-6906
Editor: Oxford University Press
DOI: 10.1093/hmg/ddab026

The KiNG of reproduction: Kisspeptin/ nNOS interactions shaping hypothalamic GnRH release

Autores: Virginia Delli, Mauro S.B. Silva, Vincent Prévot, Konstantina Chachlaki
Publicado en: Molecular and Cellular Endocrinology, Edición 532, 2021, Página(s) 111302, ISSN 0303-7207
Editor: Elsevier BV
DOI: 10.1016/j.mce.2021.111302

Novel insights into minipuberty and GnRH: Implications on neurodevelopment, cognition, and COVID-19 therapeutics

Autores: Chachlaki K*, Le Duc K, Storme L, Prevot V*
Publicado en: Journal of Neuroendocrinology, 2024, ISSN 1365-2826
Editor: Wiley
DOI: 10.1111/jne.13387

pyTWMR: transcriptome-wide Mendelian randomization in python

Autores: Sergey Oreshkov, Kaido Lepik, Federico Santoni
Publicado en: Bioinformatics, Edición 40, 2024, Página(s) online, ISSN 1367-4811
Editor: Oxford University Press (OUP)
DOI: 10.1093/bioinformatics/btae505

[Minipuberty: A critical period for brain functional development]

Autores: """ Konstantina Chachlaki, Kevin Le Duc, Laurent Storme, Vincent Prévot"""
Publicado en: Med Sci (Paris), 2023, ISSN 0767-0974
Editor: Editions E D K
DOI: 10.1051/medsci/2023113

A role for GnRH in olfaction and cognition: Implications for veterinary medicine

Autores: Vincent Prévot, Anne Duittoz
Publicado en: Reprod Domest Anim, 2023, ISSN 0936-6768
Editor: Blackwell Publishing Inc.
DOI: 10.1111/rda.14411

Male minipuberty involves the gonad-independent activation of preoptic nNOS neurons

Autores: Virginia Dellia Julien Dehame Delphine Franssen S.Rasika Anne-Simone Parent Vincent Prevot Konstantina Chachlaki
Publicado en: Free Radical Biology and Medicine, 2022, Página(s) ALL, ISSN 0891-5849
Editor: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2022.11.040

Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans

Autores: Edouard G. Mills, Mauro S.B. Silva, Virginia Delli, Laurine Decoster, Gaetan Ternier, Jovanna Tsoutsouki, Layla Thurston, Maria Phylactou, Bijal Patel, Lisa Yang, Sophie A. Clarke, Megan Young, Emma C. Alexander, Sandhi Nyunt, Arthur C. Yeung, Muhammad Choudhury, Anastasia Newman, Paul Bech, Ali Abbara, Magda Swedrowska, Ben Forbes, Vincent Prévot, Konstantina Chachlaki, Paolo Giacobini, Alexande
Publicado en: eBioMedicine, Edición 115, 2025, Página(s) 105689, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105689

Defective Nitric oxide pathway signalling - a link between premature birth and altered mini-puberty?

Autores: Jordan Read, Virginia Delli, Leo Dunkel, Federico Santoni, Vincent Prevot, Leonardo Guasti, Konstantina Chachlaki, Sasha Howard
Publicado en: Endocrine Abstracts, 2025, ISSN 1479-6848
Editor: Bioscientifica
DOI: 10.1530/endoabs.110.p919

CoverageMaster: comprehensive CNV detection and visualization from NGS short reads for genetic medicine applications

Autores: Melivoia Rapti, Yassine Zouaghi, Jenny Meylan, Emmanuelle Ranza, Stylianos E Antonarakis, Federico A Santoni 
Publicado en: Briefings in Bioinformatics, 2019, ISSN 1467-5463
Editor: Oxford University Press
DOI: 10.1093/bib/bbac049

Risk Factors for Hearing Loss Are Comparable in Preterm Versus Term Children: A Systematic Review

Autores: Pauline Roehrs, Anna‐Katharina Rohlfs, Reinhard Vonthein, Camilla Simon, Juliane Spiegler
Publicado en: Acta Paediatrica, Edición 114, 2025, Página(s) 2763-2782, ISSN 0803-5253
Editor: Taylor & Francis
DOI: 10.1111/apa.70222

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

Autores: """ Florent Sauve*, Sreekala Nampoothiri*, Sophie A Clarke*, Daniela Fernandois*, Caio Fernando Ferreira Coêlho*, Julie Dewisme, Edouard G Mills, Gaetan Ternier , Ludovica Cotellessa, Cristina Iglesias-Garcia, Helge Mueller-Fielitz, Thibaud Lebouvier, Romain Perbet, Vincent Florent, Marc Baroncini, Ariane Sharif, June Ereño-Orbea, Maria Mercado-Gómez, Asis Palazon, Virginie Mattot, Florence Pasqu"
Publicado en: EBioMedicine, 2024, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104784

Preventing and correcting polycystic ovary syndrome by targeting anti-Müllerian hormone signaling in minipuberty and adulthood in mice

Autores: Ludovica Cotellessa, Veronica Sobrino, Mauro S.B. Silva, Maxime Delit, Hélène Maitre, Emilie Caron, Gaëtan Ternier, Natalia da Silva Lima, Tori Lhomme, Frank Giton, Andrea Sorrentino, Laura Carraresi, Giovanna Di Nardo, Ruben Nogueiras, Manuel Tena-Sempere, Vincent Prevot, Paolo Giacobini
Publicado en: Cell Metabolism, Edición 37, 2026, Página(s) 1260-1276.e8, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2025.03.013

Whole genome sequencing and single-cell transcriptomics identify KMT2D inactivation as a potential new driver for pituitary tumors: a case report

Autores: Maxime Brunner, Jenny Meylan-Merlini, Maude Muriset, Sergey Oreshkov, Andrea Messina, Mahmoud Messerer, Roy Daniel, Ekkehard Hewer, Jean Phillipe Brouland, Federico Santoni
Publicado en: BJC Reports, Edición 3, 2025, Página(s) online, ISSN 2731-9377
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44276-025-00155-0

Treatment With Inhaled Nitric Oxide and General Intelligence in Preterm Children in Two European Cohorts

Autores: Nicole Tsalacopoulos, Valérie Benhammou, Laetitia Marchand‐Martin, Véronique Pierrat, Pierre‐Yves Ancel, Armita Shahesmaeilinejad, Viktoria Rücker, Vincent Prevot, Konstantina Chachlaki, Christoph Härtel, Wolfgang Göpel, Juliane Spiegler, null null
Publicado en: Acta Paediatrica, Edición 114, 2026, Página(s) 2346-2356, ISSN 0803-5253
Editor: Taylor & Francis
DOI: 10.1111/apa.70118

NOS1 mutations in humans cause hypogonadotropic hypogonadism with sensory and intellectual comorbidities, reversible experimentally by NO treatment at minipuberty

Autores: Konstantina Chachlaki, Andrea Messina Virginia Delli Valerie Leysen Csilla Maurnyi Chieko Huber Gaëtan Ternier Katalin Skrapits Georgios Papadakis Sonal Shruti Maria Kapanidou Xu Cheng James Acierno Jesse Rademaker Sowmyalakshmi Rasika Richard Quinton Marek Niedziela Dagmar L’allemand Duarte Pignatelli Mirjam Dirlewander Mariarosaria Lang-Muritano Patrick Kempf Sophie Catteau
Publicado en: Science Translational Medicine, Edición Vol. 14, 2022, Página(s) all, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abh2369

New Horizons: Gonadotropin-Releasing Hormone and Cognition

Autores: """Vincent Prévot , Manuel Tena-Sempere, Nelly Pitteloud """
Publicado en: J Clin Endocrol Metab, 2023, ISSN 0021-972X
Editor: The Endocrine Society
DOI: 10.1210/clinem/dgad319

Non-peer reviewed articles (1)

Seeing through the fog: a neuroendocrine explanation for post-covid cognitive deficit

Autores: S Rasika, Ruben Nogueiras, Markus Schwaninger, Vincent Prevot
Publicado en: Nature Review Endocrinology, 2024, ISSN 1759-5037
Editor: Nature
DOI: 10.1038/s41574-024-00955-3

Book chapters (1)

Volume Transmission of Neurotransmitters and Neuropeptides in the Brain

Autores: Betty Rodriguez Cortes, Konstantina Chachlaki, Vincent Prevot
Publicado en: Masterclass in Neuroendocrinology, Evolutionary and Comparative Neuroendocrinology, 2025, Página(s) 71-100, ISSN 2662-20682662-2076
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-80209-6_3