Associative mechanisms linking a defective minipuberty to the appearance of mental and nonmental disorders: infantile NO replenishment as a new therapeutic possibility

Informazioni relative al progetto

miniNO

ID dell’accordo di sovvenzione: 847941

DOI

10.3030/847941

Data della firma CE 5 Dicembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 31 Ottobre 2026

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 6 487 770,00

Contributo UE

€ 6 487 770,00

Coordinato da

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

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I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (1)

Novel transgenic mouse model

Websites, patent fillings, videos etc. (1)

Project website and communication tools

Project visual identity: Logo, templates, .... and project leaflet

Pubblicazioni

Peer reviewed articles (18)

Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra's seminal work

Autori: Greg M Anderson, Jennifer W Hill, Ursula B Kaiser, Victor M Navarro, Ken K Ong , John R B Perry, Vincent Prevot, Manuel Tena-Sempere, Carol F Elias
Pubblicato in: Nature Review Endocrinology, 2024, ISSN 1759-5037
Editore: Nature
DOI: 10.1038/s41574-023-00919-z

Dominant monoallelic variant in the PAK2 gene causes Knobloch syndrome type 2

Autori: Stylianos E Antonarakis, Ales Holoubek, Melivoia Rapti, Jesse Rademaker, Jenny Meylan, Justyna Iwaszkiewicz, Vincent Zoete, Callum Wilson, Juliet Taylor, Muhammad Ansar, Christelle Borel, Olivier Menzel, Kateřina Kuželová, Federico A Santoni
Pubblicato in: Human Molecular Genetics, 2021, Pagina/e in press, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddab026

The KiNG of reproduction: Kisspeptin/ nNOS interactions shaping hypothalamic GnRH release

Autori: Virginia Delli, Mauro S.B. Silva, Vincent Prévot, Konstantina Chachlaki
Pubblicato in: Molecular and Cellular Endocrinology, Numero 532, 2021, Pagina/e 111302, ISSN 0303-7207
Editore: Elsevier BV
DOI: 10.1016/j.mce.2021.111302

Novel insights into minipuberty and GnRH: Implications on neurodevelopment, cognition, and COVID-19 therapeutics

Autori: Chachlaki K*, Le Duc K, Storme L, Prevot V*
Pubblicato in: Journal of Neuroendocrinology, 2024, ISSN 1365-2826
Editore: Wiley
DOI: 10.1111/jne.13387

pyTWMR: transcriptome-wide Mendelian randomization in python

Autori: Sergey Oreshkov, Kaido Lepik, Federico Santoni
Pubblicato in: Bioinformatics, Numero 40, 2024, Pagina/e online, ISSN 1367-4811
Editore: Oxford University Press (OUP)
DOI: 10.1093/bioinformatics/btae505

[Minipuberty: A critical period for brain functional development]

Autori: """ Konstantina Chachlaki, Kevin Le Duc, Laurent Storme, Vincent Prévot"""
Pubblicato in: Med Sci (Paris), 2023, ISSN 0767-0974
Editore: Editions E D K
DOI: 10.1051/medsci/2023113

A role for GnRH in olfaction and cognition: Implications for veterinary medicine

Autori: Vincent Prévot, Anne Duittoz
Pubblicato in: Reprod Domest Anim, 2023, ISSN 0936-6768
Editore: Blackwell Publishing Inc.
DOI: 10.1111/rda.14411

Male minipuberty involves the gonad-independent activation of preoptic nNOS neurons

Autori: Virginia Dellia Julien Dehame Delphine Franssen S.Rasika Anne-Simone Parent Vincent Prevot Konstantina Chachlaki
Pubblicato in: Free Radical Biology and Medicine, 2022, Pagina/e ALL, ISSN 0891-5849
Editore: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2022.11.040

Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans

Autori: Edouard G. Mills, Mauro S.B. Silva, Virginia Delli, Laurine Decoster, Gaetan Ternier, Jovanna Tsoutsouki, Layla Thurston, Maria Phylactou, Bijal Patel, Lisa Yang, Sophie A. Clarke, Megan Young, Emma C. Alexander, Sandhi Nyunt, Arthur C. Yeung, Muhammad Choudhury, Anastasia Newman, Paul Bech, Ali Abbara, Magda Swedrowska, Ben Forbes, Vincent Prévot, Konstantina Chachlaki, Paolo Giacobini, Alexande
Pubblicato in: eBioMedicine, Numero 115, 2025, Pagina/e 105689, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105689

Defective Nitric oxide pathway signalling - a link between premature birth and altered mini-puberty?

Autori: Jordan Read, Virginia Delli, Leo Dunkel, Federico Santoni, Vincent Prevot, Leonardo Guasti, Konstantina Chachlaki, Sasha Howard
Pubblicato in: Endocrine Abstracts, 2025, ISSN 1479-6848
Editore: Bioscientifica
DOI: 10.1530/endoabs.110.p919

CoverageMaster: comprehensive CNV detection and visualization from NGS short reads for genetic medicine applications

Autori: Melivoia Rapti, Yassine Zouaghi, Jenny Meylan, Emmanuelle Ranza, Stylianos E Antonarakis, Federico A Santoni 
Pubblicato in: Briefings in Bioinformatics, 2019, ISSN 1467-5463
Editore: Oxford University Press
DOI: 10.1093/bib/bbac049

Risk Factors for Hearing Loss Are Comparable in Preterm Versus Term Children: A Systematic Review

Autori: Pauline Roehrs, Anna‐Katharina Rohlfs, Reinhard Vonthein, Camilla Simon, Juliane Spiegler
Pubblicato in: Acta Paediatrica, Numero 114, 2025, Pagina/e 2763-2782, ISSN 0803-5253
Editore: Taylor & Francis
DOI: 10.1111/apa.70222

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

Autori: """ Florent Sauve*, Sreekala Nampoothiri*, Sophie A Clarke*, Daniela Fernandois*, Caio Fernando Ferreira Coêlho*, Julie Dewisme, Edouard G Mills, Gaetan Ternier , Ludovica Cotellessa, Cristina Iglesias-Garcia, Helge Mueller-Fielitz, Thibaud Lebouvier, Romain Perbet, Vincent Florent, Marc Baroncini, Ariane Sharif, June Ereño-Orbea, Maria Mercado-Gómez, Asis Palazon, Virginie Mattot, Florence Pasqu"
Pubblicato in: EBioMedicine, 2024, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104784

Preventing and correcting polycystic ovary syndrome by targeting anti-Müllerian hormone signaling in minipuberty and adulthood in mice

Autori: Ludovica Cotellessa, Veronica Sobrino, Mauro S.B. Silva, Maxime Delit, Hélène Maitre, Emilie Caron, Gaëtan Ternier, Natalia da Silva Lima, Tori Lhomme, Frank Giton, Andrea Sorrentino, Laura Carraresi, Giovanna Di Nardo, Ruben Nogueiras, Manuel Tena-Sempere, Vincent Prevot, Paolo Giacobini
Pubblicato in: Cell Metabolism, Numero 37, 2026, Pagina/e 1260-1276.e8, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2025.03.013

Whole genome sequencing and single-cell transcriptomics identify KMT2D inactivation as a potential new driver for pituitary tumors: a case report

Autori: Maxime Brunner, Jenny Meylan-Merlini, Maude Muriset, Sergey Oreshkov, Andrea Messina, Mahmoud Messerer, Roy Daniel, Ekkehard Hewer, Jean Phillipe Brouland, Federico Santoni
Pubblicato in: BJC Reports, Numero 3, 2025, Pagina/e online, ISSN 2731-9377
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44276-025-00155-0

Treatment With Inhaled Nitric Oxide and General Intelligence in Preterm Children in Two European Cohorts

Autori: Nicole Tsalacopoulos, Valérie Benhammou, Laetitia Marchand‐Martin, Véronique Pierrat, Pierre‐Yves Ancel, Armita Shahesmaeilinejad, Viktoria Rücker, Vincent Prevot, Konstantina Chachlaki, Christoph Härtel, Wolfgang Göpel, Juliane Spiegler, null null
Pubblicato in: Acta Paediatrica, Numero 114, 2026, Pagina/e 2346-2356, ISSN 0803-5253
Editore: Taylor & Francis
DOI: 10.1111/apa.70118

NOS1 mutations in humans cause hypogonadotropic hypogonadism with sensory and intellectual comorbidities, reversible experimentally by NO treatment at minipuberty

Autori: Konstantina Chachlaki, Andrea Messina Virginia Delli Valerie Leysen Csilla Maurnyi Chieko Huber Gaëtan Ternier Katalin Skrapits Georgios Papadakis Sonal Shruti Maria Kapanidou Xu Cheng James Acierno Jesse Rademaker Sowmyalakshmi Rasika Richard Quinton Marek Niedziela Dagmar L’allemand Duarte Pignatelli Mirjam Dirlewander Mariarosaria Lang-Muritano Patrick Kempf Sophie Catteau
Pubblicato in: Science Translational Medicine, Numero Vol. 14, 2022, Pagina/e all, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abh2369

New Horizons: Gonadotropin-Releasing Hormone and Cognition

Autori: """Vincent Prévot , Manuel Tena-Sempere, Nelly Pitteloud """
Pubblicato in: J Clin Endocrol Metab, 2023, ISSN 0021-972X
Editore: The Endocrine Society
DOI: 10.1210/clinem/dgad319

Non-peer reviewed articles (1)

Seeing through the fog: a neuroendocrine explanation for post-covid cognitive deficit

Autori: S Rasika, Ruben Nogueiras, Markus Schwaninger, Vincent Prevot
Pubblicato in: Nature Review Endocrinology, 2024, ISSN 1759-5037
Editore: Nature
DOI: 10.1038/s41574-024-00955-3

Book chapters (1)

Volume Transmission of Neurotransmitters and Neuropeptides in the Brain

Autori: Betty Rodriguez Cortes, Konstantina Chachlaki, Vincent Prevot
Pubblicato in: Masterclass in Neuroendocrinology, Evolutionary and Comparative Neuroendocrinology, 2025, Pagina/e 71-100, ISSN 2662-20682662-2076
Editore: Springer Nature Switzerland
DOI: 10.1007/978-3-031-80209-6_3