Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications,antimicrobial drug resistance,and unresponsiveness to therapeutic HIV-1 vaccination

Project description

Gut microbiome for tackling HIV infection

Although the microbiome has been the subject of intense research over recent decades, very few publications have addressed its potential role in HIV/AIDS - and most of these have focused on the genital microbiome. Increasing evidence supports a role for the gut microbiome in immune system disorders, chronic inflammation and accelerated ageing, all hallmarks of HIV-1 infection. The EU-funded MISTRAL project is exploring the gut microbiota in relation to HIV-1, seeking microbiome biomarkers to support development of interventions that mitigate infection and enhance response to vaccines and therapies. In addition, the creation of a publicly accessible database will aid inpatient screening and stratification. A cloud-based tool will also facilitate microbiome interpretation for reseach and clinical purposes.

Fields of science

• medical and health sciences › health sciences › infectious disease › RNA virus › hiv
• medical and health sciences › basic medicine › pharmacology and pharmacy › drug resistance

Programme(s)

• H2020-EU.3.1.3. - Treating and managing disease

Topic(s)

• SC1-BHC-14-2019 - Stratified host-directed approaches to improve prevention, treatment and/or cure of infectious diseases

Call for proposal

H2020-SC1-2019-Two-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA

Address

Carretera De Canyet
08916 Barcelona
Spain

Activity type

Research Organisations

EU contribution

€ 3 967 500

Participants (10)

UNIVERSITE D'AIX MARSEILLE

France

EU contribution

€ 730 470

Address

Boulevard Charles Livon 58
13284 Marseille

Activity type

Higher or Secondary Education Establishments

REGION HOVEDSTADEN

Denmark

EU contribution

€ 1 017 611,25

Address

Kongens Vaenge 2
3400 Hillerod

Activity type

Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)

CASE WESTERN RESERVE UNIVERSITY CORPORATION

United States

EU contribution

€ 727 787,50

Address

Euclid Avenue 10900
44106 7037 Cleveland Ohio

Activity type

Higher or Secondary Education Establishments

KAROLINSKA INSTITUTET

Sweden

EU contribution

€ 1 490 833,75

Address

Nobels Vag 5
17177 Stockholm

Activity type

Higher or Secondary Education Establishments

PROJECTE DELS NOMS - HISPANOSIDA ASOCIACION

Spain

EU contribution

€ 236 737,50

Address

Comte Borrell 164 166 Baixos
08015 Barcelona

Activity type

Other

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Spain

EU contribution

€ 351 762,50

Address

Calle Rossello 149 Puerta Bjs
08036 Barcelona

Activity type

Other

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA

Spain

EU contribution

€ 448 021,25

Address

C Rossello 132 Planta 05
08036 Barcelona

Activity type

Research Organisations

ASPHALION SL

Spain

EU contribution

€ 316 187,50

Address

Calle Tarragona, Numeros 151-157, Planta 10, Bloqu
08014 Barcelona

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

AELIX THERAPEUTICS SL

Spain

EU contribution

€ 534 978,75

Address

Calle Baldiri Reixac, 4-8
08028 Barcelona

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

VEDANTA BIOSCIENCES INC

United States

EU contribution

€ 172 493,75

Address

Corporation Trust Center 1209 Orange Street
19801 Wilmington

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)