Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications,antimicrobial drug resistance,and unresponsiveness to therapeutic HIV-1 vaccination

Project Information

MISTRAL

Grant agreement ID: 847943

DOI

10.3030/847943

Project closed

EC signature date 11 December 2019

Start date 1 January 2020

End date 31 December 2025

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 9 994 383,75

EU contribution

€ 9 994 383,75

Coordinated by

FUNDACIO PRIVADA INSTITUT DE RECERCA SOBRE IMMUNOPATOLOGIES-CAIXA, IRSICAIXA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (6)

Dissemination material: compilation of articles, flyers, brochures, posters, etc. for project diffusion v1

Compilation of dissemination material

Integrated analysis

Workplan for integrated analysis within group within each focus group

Report on the completion of ADVANZ-4 microbiome RCT

Main findings of the ADVANZ-4 microbiome clinical trial will be reported upon finalization.

Report on the completion of RECOVER RCT

The main findings of the RECOVER RCT clinical trial will be reported upon it finalization

Dissemination and communication plan

A communication plan to reach stakeholders of the project will be set out.

Handbook on management

Document to support partners in the administrative aspects related to the project.

Other (1)

EntheraMicrobiome automatized data analysis for 16s and WMGS

Enthera Web producing microbiome automatized data analysis for 16s and WMGS, minimal interface

Open Research Data Pilot (1)

Data management plan

Open Research Data Pilot deliverable. data management plan

Websites, patent fillings, videos etc. (1)

Mistral website

iVIHome will be the main communication tool of the MISTRAL project. The website will be created at the beginning of the project including not only links and documents of interest for the scientific and end user community, but also general information, written in an understandable way for non-specialist public, as well representative data and information. The website will contain both a public section and a stakeholders’ section. The public area will contain general information on the project, partners’ contact details, useful links and information on relevant microbiome portals and resources, events and workshops, project news, a download area for downloading project brochures, videos, and other useful material such as public deliverables. Partners will post news and links to the activities developed by them, as well as publications, events, tools, protocols and software used by or generated by them. Moreover, iVIHome will be an integrated, comprehensive and freely accessible repository of all HIV microbiome data generated during the MISTRAL project. It will also post news and links to the activities developed by the different institution members of the MISTRAL consortium, including publications, workshops and other outreach activities.

Publications

Peer reviewed articles (19)

Spatial transcriptomics and in situ immune cell profiling of the host ectocervical landscape of HIV infected Kenyan sex working women

Author(s): Mathias Franzén Boger, Vilde Kaldhusdal, Anna Pascual-Reguant, Sandy Kroh, Ralf Uecker, Adam D. Burgener, Julie Lajoie, Kenneth Omollo, Joshua Kimani, Keith R. Fowke, Anja E. Hauser, Annelie Tjernlund, Kristina Broliden
Published in: Frontiers in Immunology, Issue 15, 2024, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1483346

Spatial transcriptomics unveils estrogen-modulated immune responses and structural alterations in the ectocervical mucosa of depot medroxyprogesterone acetate users

Author(s): Vilde Kaldhusdal, Mathias Franzen Boger, Annelie Tjernlund, Adam D. Burgener, Frideborg Bradley, Julie Lajoie, Kenneth Omollo, Joshua Kimani, Keith Fowke, Paulo Czarnewski, Kristina Broliden
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-83775-9

Impact of doxycycline pre-exposure prophylaxis (doxyPrEP) for sexually transmitted infections on the microbiome of men who have sex with men on HIV PrEP

Author(s): Samantha Knodel, Leighanne Main, Marlon DeLeon, Alana Lamont, Joshua Edward, Amit K. Gupta, Laura Noel-Romas, Saira Mohammed, Tessa Tattersall, Jason Wong, Mark Hull, Troy Grennan, Adam D. Burgener
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-61426-5

Vaccination with an HIV T-cell immunogen induces alterations in the mouse gut microbiota

Author(s): Alessandra Borgognone; Aleix Elizalde-Torrent; Maria Casadellà; Luis Romero; Tuixent Escribà; Mariona Parera; Francesc Català-Moll; Marc Noguera-Julian; Christian Brander; Alex Olvera; Roger Paredes
Published in: NPJ Biofilms Microbiomes, Issue 1, 2022, ISSN 2055-5008
Publisher: Nature Publishing Group
DOI: 10.21203/rs.3.rs-1997415/v1

In vitro antibacterial activity of antiretroviral drugs on key commensal bacteria from the human microbiota

Author(s): Elisa Rubio-Garcia, Núria Ferrando, Núria Martin, Clara Ballesté-Delpierre, Jose M Miró, Roger Paredes, Climent Casals-Pascual, Jordi Vila
Published in: Front Cell Infect Microbiol, Issue 8:13:1306430, 2024, ISSN 2235-2988
Publisher: Frontiers Media S. A.
DOI: 10.3389/fcimb.2023.1306430

Impact of ChAdOx1 or DNA Prime Vaccination on Magnitude, Breadth, and Focus of MVA-Boosted Immunogen-Specific T Cell Responses

Author(s): Alex Olvera, Luis Romero-Martin, Bruna Oriol-Tordera, Miriam Rosas-Umbert, Tuixent Escribà, Beatriz Mothe, Christian Brander
Published in: Vaccines, Issue 12(3), 279, 7 March 2024, 2024, Page(s) 1 to 16, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines12030279

Vaccination with an HIV T-Cell Immunogen (HTI) Using DNA Primes Followed by a ChAdOx1-MVA Boost Is Immunogenic in Gut Microbiota-Depleted Mice despite Low IL-22 Serum Levels

Author(s): Aleix Elizalde-Torrent, Alessandra Borgognone, Maria Casadellà, Luis Romero-Martin, Tuixent Escribà, Mariona Parera, Yaiza Rosales-Salgado, Jorge Díaz-Pedroza, Francesc Català-Moll, Marc Noguera-Julian, Christian Brander, Roger Paredes, Alex Olvera
Published in: Vaccines, Issue 11(11), 1663, 30 October 2023, 2023, Page(s) 1 to 17, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11111663

Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial

Author(s): Bailón L, Llano A, Cedeño S et al; and AELIX002 Study Group
Published in: Nature Medicine, 2022, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-022-02060-2

The cervicovaginal microbiome associates with spatially restricted host transcriptional signatures throughout the human ectocervical epithelium and submucosa

Author(s): Vilde Kaldhusdal, Mathias Franzén Boger, Adam D. Burgener, Julie Lajoie, Kenneth Omollo, Joshua Kimani, Annelie Tjernlund, Keith R. Fowke, Douglas S. Kwon, Gabriella Edfeldt, Kristina Broliden
Published in: PLOS Pathogens, Issue 21, 2025, Page(s) e1013677, ISSN 1553-7374
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.ppat.1013677

Probiotic effects on immunity and microbiome in HIV-1 discordant patients

Author(s): Carlos Blázquez-Bondia; Mariona Parera; Francesc Català-Moll; Maria Casadellà; Aleix Elizalde-Torrent; Meritxell Aguiló; Jordi Espadaler-Mazo; José Ramon Santos; Roger Paredes; Marc Noguera-Julian
Published in: Frontiers in Immunology, Issue 1, 2022, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2022.1066036

Dolutegravir restores gut microbiota in late-stage HIV-1 unlike darunavir: an open-label, randomized clinical trial

Author(s): Francesc Català-Moll, Carlos Blázquez-Bondia, Judit Farré-Badia, Ferran Torres, Christian Manzardo, Eva Bonfill, Adrià Curran, Pere Domingo, Daniel Podzamczer, Lluís Force, Vicenç Falcó, Mariona Parera, Maria Casadellà, José Maria Miró, Marc Noguera-Julian, Roger Paredes, null null, null null, Alessandra Borgognone, Nel Marín, Oriol Careta, Valentina Triviño, null null, Anna Cruceta, N
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-026-69846-7

Interactions between gut microbiota, plasma metabolome and brain function in the setting of a HIV cure trial

Author(s): Alessandra Borgognone, Anna Prats, Ashish Arunkumar Sharma, Ignacio Martinez-Zalacaín, Carles Soriano-Mas, Christian Brander, Bonaventura Clotet, José Moltó, Beatriz Mothe, Rafick-Pierre Sekaly, Roger Paredes, Jose A. Muñoz-Moreno
Published in: Frontiers in Cellular and Infection Microbiology, Issue 15, 2025, ISSN 2235-2988
Publisher: Frontiers Media S. A.
DOI: 10.3389/fcimb.2025.1629901

Exploring potential associations between the human microbiota and reservoir of latent HIV

Author(s): Nel Marín-Sánchez, Roger Paredes, Alessandra Borgognone
Published in: Retrovirology, Issue 21, 2024, ISSN 1742-4690
Publisher: BioMed Central
DOI: 10.1186/s12977-024-00655-w

Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome

Author(s): Bruna Oriol-Tordera, Anna Esteve-Codina, María Berdasco, Míriam Rosás-Umbert, Elena Gonçalves, Clara Duran-Castells, Francesc Català-Moll, Anuska Llano, Samandhy Cedeño, Maria C. Puertas, Martin Tolstrup, Ole S. Søgaard, Bonaventura Clotet, Javier Martínez-Picado, Tomáš Hanke, Behazine Combadiere, Roger Paredes, Dennis Hartigan-O'Connor, Manel Esteller, Michael Meulbroek, María Luz Call
Published in: eBioMedicine, Issue 78, 2023, Page(s) 103956, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2022.103956

Host Transcriptome and Microbiota Signatures Prior to Immunization Profile Vaccine Humoral Responsiveness

Author(s): Elena Gonçalves, Yolanda Guillén, Javier R. Lama, Jorge Sanchez, Christian Brander, Roger Paredes, Behazine Combadière
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Lausanne: Frontiers Media S.A
DOI: 10.3389/fimmu.2021.657162

Gut resistome linked to sexual preference and HIV infection

Author(s): Elisa Rubio Garcia, Maria Casadellà, Mariona Parera, Jordi Vila, Roger Paredes, and Marc Noguera-Julian
Published in: BMC Microbiol., Issue 2024; 24: 201, 2024, ISSN 1471-2180
Publisher: BioMed Central
DOI: 10.1186/s12866-024-03335-z

Estradiol-mediated enhancement of the human ectocervical epithelial barrier correlates with desmoglein-1 expression in the follicular menstrual phase

Author(s): Frideborg Bradley, Alexandra Stern, Mathias Franzén Boger, Zaynab Mousavian, Olga Dethlefsen, Vilde Kaldhusdal, Julie Lajoie, Kenneth Omollo, Sofia Bergström, Anna Månberg, Peter Nilsson, Joshua Kimani, Adam D. Burgener, Annelie Tjernlund, Christopher Sundling, Keith R. Fowke, Kristina Broliden
Published in: Frontiers in Endocrinology, Issue 15, 2024, ISSN 1664-2392
Publisher: Frontiers Media SA
DOI: 10.3389/fendo.2024.1454006

Gut microbiome signatures linked to HIV-1 reservoir size and viremia control

Author(s): Alessandra Borgognone; Bruna Oriol-Tordera; Beatriz Mothe; Roger Paredes; Maria C. Puertas
Published in: Microbiome, Issue 3, 2022, ISSN 2049-2618
Publisher: Springer Nature
DOI: 10.1186/s40168-022-01247-6

Immune reconstitution in very advanced HIV patients treated with dolutegravir vs. darunavir-based triple antiretroviral therapy: the Advanz-4 randomized clinical trial

Author(s): Jose M. Miro, Ferran Torres, Christian Manzardo, Eva Bonfill, Adrià Curran, Pere Domingo, Daniel Podzamczer, Roger Paredes, Lluis Force, Vicenç Falco, Mar Gutierrez, Maria Saumoy, Anna Castelli, Alexy Inciarte, Cristina Rovira, Anna Cruceta, Carmen Hurtado, Núria Climent, Francisco Lozano, Montserrat Plana, Jose M. Miro, Ferran Torres, Christian Manzardo, Eva Bonfill, Anna Cruceta, Núria Clime
Published in: Clinical Microbiology and Infection, Issue 32, 2026, Page(s) 169-176, ISSN 1198-743X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2025.09.026

Other (4)

B-Cell Gene Expression and Microbiota Prior Immunization Profile Vaccine Humoral Responsiveness

Author(s): Elena Gonçalves, Yolanda Guillén, Javier R Lama, Jorge Sanchez, Christian Brander, Roger Paredes, Behazine Combadière
Published in: 2021
Publisher: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-46833/v1

IN_CERT Programme

Author(s): Mercè Pomer; Queralt Morros; Roger Paredes; Cristina Vilaplana; Lourdes Mateu; Manel Guerrero; Jo Milne; Nora Ancarola; Adolf Alcañiz
Published in: Projecte IN_CERT. Art, Ciència i Pensament des de la Pandèmia, Issue 1, 2021
Publisher: Ajuntament d'Alella
DOI: 10.5281/zenodo.5608507

Probiotic effects on immunity and microbiome in HIV-1 discordant patients

Author(s): Blázquez-Bondia, Carlos; Parera, Mariona; Català-Moll, Francesc; Casadellà, Maria; Elizalde-Torrent, Aleix; Aguiló, Meritxell; Espadaler Mazo, Jordi; Santos, José Ramon; Paredes, Roger; Noguera-Julian, Marc; Universitat Autònoma de Barcelona
Published in: Issue 3, 2022
Publisher: https://ddd.uab.cat/record/281731

Vaccination with an HIV T-Cell Immunogen (HTI) Using DNA Primes Followed by a ChAdOx1-MVA Boost Is Immunogenic in Gut Microbiota-Depleted Mice despite Low IL-22 Serum Levels

Author(s): Elizalde-Torrent, Aleix; Borgognone, Alessandra; Casadellà, Maria; Romero-Martín, Luis; Escribà, Tuixent; Parera, Mariona; Rosales-Salgado, Yaiza; Díaz-Pedroza, Jorge; Català-Moll, Francesc; Noguera-Julian, Marc; Brander, Christian; Paredes, Roger; Olvera, Alex; Universitat Autònoma de Barcelona
Published in: https://ddd.uab.cat/record/294075, Issue 2, 2023
Publisher: https://ddd.uab.cat/record/294075

Conference proceedings (5)

RECOVER: Immune reconstitution with synbiotics in HIV-1 infected immunodiscordant patients

Author(s): Carlos Blázquez-Bondia, Mariona Parera, Francesc Català-Moll, Maria Casadellà, Aleix Elizalde-Torrent, Meritxell Aguilo, Jordi Espadaler-Mazo, José Ramon Santos, Roger Paredes and Marc Noguera-Julian
Published in: 2022
Publisher: IHMC KOBE 2022

Repurposing Elvitegravir as a novel antibiotic against multidrug-resistant Gram-positive bacteria

Author(s): Núria Martín et al
Published in: Flash sessions ECCMID 2024 BCN, 2024
Publisher: ECCMID 2024 BCN

Consensus-based robustness for differential abundance testing in microbiome data analysis

Author(s): Francesc Català-Moll, Roger Paredes, Marc Noguera-Julian
Published in: 2022
Publisher: IHMC KOBE 2022

A placebo-controlled ATI trial of HTI vaccines in early treated HIV infection

Author(s): Bailón L, Llano A, Cedeño S et al; and AELIX002 Study Group
Published in: Topics in Antiviral Medicine. Special Issue: Abstracts from the 21 Virtual Conference on Retroviruses and Opportunistic Infections (CROI), Issue Volume 29, Issue 1, March 2021, 2021, Page(s) Abstract NR 161
Publisher: Abstracts from the 21 Virtual Conference on Retroviruses and Opportunistic Infections (CROI)

Vaccination with an HIV T-cell immunogen induces alterations in the mouse gut microbiota

Author(s): Alessandra Borgognone, Aleix Elizalde-Torrent, Maria Casadellà, Luis Romero, Tuixent Escribà, Mariona Parera, Francesc Català-Moll, Marc Noguera-Julian, Christian Brander, Alex Olvera, and Roger Paredes
Published in: 2022
Publisher: IHMC KOBE 2022