Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications,antimicrobial drug resistance,and unresponsiveness to therapeutic HIV-1 vaccination

Project Information

MISTRAL

Grant agreement ID: 847943

DOI 10.3030/847943

EC signature date 11 December 2019

Start date 1 January 2020

End date 30 June 2025

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 9 994 383,75

EU contribution € 9 994 383,75

Coordinated by

FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA
Spain

Deliverables

Documents, reports (4)

Dissemination material: compilation of articles, flyers, brochures, posters, etc. for project diffusion v1

Compilation of dissemination material

Report on the completion of RECOVER RCT

The main findings of the RECOVER RCT clinical trial will be reported upon it finalization

Dissemination and communication plan

A communication plan to reach stakeholders of the project will be set out.

Handbook on management

Document to support partners in the administrative aspects related to the project.

Other (1)

EntheraMicrobiome automatized data analysis for 16s and WMGS

Enthera Web producing microbiome automatized data analysis for 16s and WMGS, minimal interface

Open Research Data Pilot (1)

Data management plan

Open Research Data Pilot deliverable. data management plan

Websites, patent fillings, videos etc. (1)

Mistral website

iVIHome will be the main communication tool of the MISTRAL project. The website will be created at the beginning of the project including not only links and documents of interest for the scientific and end user community, but also general information, written in an understandable way for non-specialist public, as well representative data and information. The website will contain both a public section and a stakeholders’ section. The public area will contain general information on the project, partners’ contact details, useful links and information on relevant microbiome portals and resources, events and workshops, project news, a download area for downloading project brochures, videos, and other useful material such as public deliverables. Partners will post news and links to the activities developed by them, as well as publications, events, tools, protocols and software used by or generated by them. Moreover, iVIHome will be an integrated, comprehensive and freely accessible repository of all HIV microbiome data generated during the MISTRAL project. It will also post news and links to the activities developed by the different institution members of the MISTRAL consortium, including publications, workshops and other outreach activities.

Publications

Other (1)

IN_CERT Programme

Author(s): Mercè Pomer; Queralt Morros; Roger Paredes; Cristina Vilaplana; Lourdes Mateu; Manel Guerrero; Jo Milne; Nora Ancarola; Adolf Alcañiz
Published in: Projecte IN_CERT. Art, Ciència i Pensament des de la Pandèmia, Issue 1, 2021
Publisher: Ajuntament d'Alella
DOI: 10.5281/zenodo.5608507

Peer reviewed articles (4)

Vaccination with an HIV T-cell immunogen induces alterations in the mouse gut microbiota

Author(s): Alessandra Borgognone; Aleix Elizalde-Torrent; Maria Casadellà; Luis Romero; Tuixent Escribà; Mariona Parera; Francesc Català-Moll; Marc Noguera-Julian; Christian Brander; Alex Olvera; Roger Paredes
Published in: NPJ Biofilms Microbiomes, Issue 1, 2022, ISSN 2055-5008
Publisher: Nature Publishing Group
DOI: 10.21203/rs.3.rs-1997415/v1

Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial

Author(s): Bailón L, Llano A, Cedeño S et al; and AELIX002 Study Group
Published in: Nature Medicine, 2022, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-022-02060-2

Probiotic effects on immunity and microbiome in HIV-1 discordant patients

Author(s): Carlos Blázquez-Bondia; Mariona Parera; Francesc Català-Moll; Maria Casadellà; Aleix Elizalde-Torrent; Meritxell Aguiló; Jordi Espadaler-Mazo; José Ramon Santos; Roger Paredes; Marc Noguera-Julian
Published in: Frontiers in Immunology, Issue 1, 2022, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2022.1066036

Gut microbiome signatures linked to HIV-1 reservoir size and viremia control

Author(s): Alessandra Borgognone; Bruna Oriol-Tordera; Beatriz Mothe; Roger Paredes; Maria C. Puertas
Published in: Microbiome, Issue 3, 2022, ISSN 2049-2618
Publisher: Springer Nature
DOI: 10.1186/s40168-022-01247-6

Conference proceedings (4)

RECOVER: Immune reconstitution with synbiotics in HIV-1 infected immunodiscordant patients

Author(s): Carlos Blázquez-Bondia, Mariona Parera, Francesc Català-Moll, Maria Casadellà, Aleix Elizalde-Torrent, Meritxell Aguilo, Jordi Espadaler-Mazo, José Ramon Santos, Roger Paredes and Marc Noguera-Julian
Published in: 2022
Publisher: IHMC KOBE 2022

Consensus-based robustness for differential abundance testing in microbiome data analysis

Author(s): Francesc Català-Moll, Roger Paredes, Marc Noguera-Julian
Published in: 2022
Publisher: IHMC KOBE 2022

A placebo-controlled ATI trial of HTI vaccines in early treated HIV infection

Author(s): Bailón L, Llano A, Cedeño S et al; and AELIX002 Study Group
Published in: Topics in Antiviral Medicine. Special Issue: Abstracts from the 21 Virtual Conference on Retroviruses and Opportunistic Infections (CROI), Issue Volume 29, Issue 1, March 2021, 2021, Page(s) Abstract NR 161
Publisher: Abstracts from the 21 Virtual Conference on Retroviruses and Opportunistic Infections (CROI)

Vaccination with an HIV T-cell immunogen induces alterations in the mouse gut microbiota

Author(s): Alessandra Borgognone, Aleix Elizalde-Torrent, Maria Casadellà, Luis Romero, Tuixent Escribà, Mariona Parera, Francesc Català-Moll, Marc Noguera-Julian, Christian Brander, Alex Olvera, and Roger Paredes
Published in: 2022
Publisher: IHMC KOBE 2022