Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications,antimicrobial drug resistance,and unresponsiveness to therapeutic HIV-1 vaccination

Informations projet

MISTRAL

N° de convention de subvention: 847943

DOI

10.3030/847943

Date de signature de la CE 11 Decembre 2019

Date de début 1 Janvier 2020

Date de fin 31 Decembre 2025

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 9 994 383,75

Contribution de l’UE

€ 9 994 383,75

Coordonné par

FUNDACIO PRIVADA INSTITUT DE RECERCA SOBRE IMMUNOPATOLOGIES-CAIXA, IRSICAIXA
Spain

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (6)

Dissemination material: compilation of articles, flyers, brochures, posters, etc. for project diffusion v1

Compilation of dissemination material

Integrated analysis

Workplan for integrated analysis within group within each focus group

Report on the completion of ADVANZ-4 microbiome RCT

Main findings of the ADVANZ-4 microbiome clinical trial will be reported upon finalization.

Report on the completion of RECOVER RCT

The main findings of the RECOVER RCT clinical trial will be reported upon it finalization

Dissemination and communication plan

A communication plan to reach stakeholders of the project will be set out.

Handbook on management

Document to support partners in the administrative aspects related to the project.

Other (1)

EntheraMicrobiome automatized data analysis for 16s and WMGS

Enthera Web producing microbiome automatized data analysis for 16s and WMGS, minimal interface

Open Research Data Pilot (1)

Data management plan

Open Research Data Pilot deliverable. data management plan

Websites, patent fillings, videos etc. (1)

Mistral website

iVIHome will be the main communication tool of the MISTRAL project. The website will be created at the beginning of the project including not only links and documents of interest for the scientific and end user community, but also general information, written in an understandable way for non-specialist public, as well representative data and information. The website will contain both a public section and a stakeholders’ section. The public area will contain general information on the project, partners’ contact details, useful links and information on relevant microbiome portals and resources, events and workshops, project news, a download area for downloading project brochures, videos, and other useful material such as public deliverables. Partners will post news and links to the activities developed by them, as well as publications, events, tools, protocols and software used by or generated by them. Moreover, iVIHome will be an integrated, comprehensive and freely accessible repository of all HIV microbiome data generated during the MISTRAL project. It will also post news and links to the activities developed by the different institution members of the MISTRAL consortium, including publications, workshops and other outreach activities.

Publications

Other (1)

IN_CERT Programme

Auteurs: Mercè Pomer; Queralt Morros; Roger Paredes; Cristina Vilaplana; Lourdes Mateu; Manel Guerrero; Jo Milne; Nora Ancarola; Adolf Alcañiz
Publié dans: Projecte IN_CERT. Art, Ciència i Pensament des de la Pandèmia, Numéro 1, 2021
Éditeur: Ajuntament d'Alella
DOI: 10.5281/zenodo.5608507

Peer reviewed articles (10)

Vaccination with an HIV T-cell immunogen induces alterations in the mouse gut microbiota

Auteurs: Alessandra Borgognone; Aleix Elizalde-Torrent; Maria Casadellà; Luis Romero; Tuixent Escribà; Mariona Parera; Francesc Català-Moll; Marc Noguera-Julian; Christian Brander; Alex Olvera; Roger Paredes
Publié dans: NPJ Biofilms Microbiomes, Numéro 1, 2022, ISSN 2055-5008
Éditeur: Nature Publishing Group
DOI: 10.21203/rs.3.rs-1997415/v1

In vitro antibacterial activity of antiretroviral drugs on key commensal bacteria from the human microbiota

Auteurs: Elisa Rubio-Garcia, Núria Ferrando, Núria Martin, Clara Ballesté-Delpierre, Jose M Miró, Roger Paredes, Climent Casals-Pascual, Jordi Vila
Publié dans: Front Cell Infect Microbiol, Numéro 8:13:1306430, 2024, ISSN 2235-2988
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fcimb.2023.1306430

Impact of ChAdOx1 or DNA Prime Vaccination on Magnitude, Breadth, and Focus of MVA-Boosted Immunogen-Specific T Cell Responses

Auteurs: Alex Olvera, Luis Romero-Martin, Bruna Oriol-Tordera, Miriam Rosas-Umbert, Tuixent Escribà, Beatriz Mothe, Christian Brander
Publié dans: Vaccines, Numéro 12(3), 279, 7 March 2024, 2024, Page(s) 1 to 16, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines12030279

Vaccination with an HIV T-Cell Immunogen (HTI) Using DNA Primes Followed by a ChAdOx1-MVA Boost Is Immunogenic in Gut Microbiota-Depleted Mice despite Low IL-22 Serum Levels

Auteurs: Aleix Elizalde-Torrent, Alessandra Borgognone, Maria Casadellà, Luis Romero-Martin, Tuixent Escribà, Mariona Parera, Yaiza Rosales-Salgado, Jorge Díaz-Pedroza, Francesc Català-Moll, Marc Noguera-Julian, Christian Brander, Roger Paredes, Alex Olvera
Publié dans: Vaccines, Numéro 11(11), 1663, 30 October 2023, 2023, Page(s) 1 to 17, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11111663

Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial

Auteurs: Bailón L, Llano A, Cedeño S et al; and AELIX002 Study Group
Publié dans: Nature Medicine, 2022, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-022-02060-2

Probiotic effects on immunity and microbiome in HIV-1 discordant patients

Auteurs: Carlos Blázquez-Bondia; Mariona Parera; Francesc Català-Moll; Maria Casadellà; Aleix Elizalde-Torrent; Meritxell Aguiló; Jordi Espadaler-Mazo; José Ramon Santos; Roger Paredes; Marc Noguera-Julian
Publié dans: Frontiers in Immunology, Numéro 1, 2022, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2022.1066036

Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome

Auteurs: Bruna Oriol-Tordera, Anna Esteve-Codina, María Berdasco, Míriam Rosás-Umbert, Elena Gonçalves, Clara Duran-Castells, Francesc Català-Moll, Anuska Llano, Samandhy Cedeño, Maria C. Puertas, Martin Tolstrup, Ole S. Søgaard, Bonaventura Clotet, Javier Martínez-Picado, Tomáš Hanke, Behazine Combadiere, Roger Paredes, Dennis Hartigan-O'Connor, Manel Esteller, Michael Meulbroek, María Luz Call
Publié dans: eBioMedicine, Numéro 78, 2023, Page(s) 103956, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2022.103956

Host Transcriptome and Microbiota Signatures Prior to Immunization Profile Vaccine Humoral Responsiveness

Auteurs: Elena Gonçalves, Yolanda Guillén, Javier R. Lama, Jorge Sanchez, Christian Brander, Roger Paredes, Behazine Combadière
Publié dans: Frontiers in Immunology, Numéro 12, 2021, ISSN 1664-3224
Éditeur: Lausanne: Frontiers Media S.A
DOI: 10.3389/fimmu.2021.657162

Gut resistome linked to sexual preference and HIV infection

Auteurs: Elisa Rubio Garcia, Maria Casadellà, Mariona Parera, Jordi Vila, Roger Paredes, and Marc Noguera-Julian
Publié dans: BMC Microbiol., Numéro 2024; 24: 201, 2024, ISSN 1471-2180
Éditeur: BioMed Central
DOI: 10.1186/s12866-024-03335-z

Gut microbiome signatures linked to HIV-1 reservoir size and viremia control

Auteurs: Alessandra Borgognone; Bruna Oriol-Tordera; Beatriz Mothe; Roger Paredes; Maria C. Puertas
Publié dans: Microbiome, Numéro 3, 2022, ISSN 2049-2618
Éditeur: Springer Nature
DOI: 10.1186/s40168-022-01247-6

Conference proceedings (5)

RECOVER: Immune reconstitution with synbiotics in HIV-1 infected immunodiscordant patients

Auteurs: Carlos Blázquez-Bondia, Mariona Parera, Francesc Català-Moll, Maria Casadellà, Aleix Elizalde-Torrent, Meritxell Aguilo, Jordi Espadaler-Mazo, José Ramon Santos, Roger Paredes and Marc Noguera-Julian
Publié dans: 2022
Éditeur: IHMC KOBE 2022

Repurposing Elvitegravir as a novel antibiotic against multidrug-resistant Gram-positive bacteria

Auteurs: Núria Martín et al
Publié dans: Flash sessions ECCMID 2024 BCN, 2024
Éditeur: ECCMID 2024 BCN

Consensus-based robustness for differential abundance testing in microbiome data analysis

Auteurs: Francesc Català-Moll, Roger Paredes, Marc Noguera-Julian
Publié dans: 2022
Éditeur: IHMC KOBE 2022

A placebo-controlled ATI trial of HTI vaccines in early treated HIV infection

Auteurs: Bailón L, Llano A, Cedeño S et al; and AELIX002 Study Group
Publié dans: Topics in Antiviral Medicine. Special Numéro: Abstracts from the 21 Virtual Conference on Retroviruses and Opportunistic Infections (CROI), Numéro Volume 29, Numéro 1, March 2021, 2021, Page(s) Abstract NR 161
Éditeur: Abstracts from the 21 Virtual Conference on Retroviruses and Opportunistic Infections (CROI)

Vaccination with an HIV T-cell immunogen induces alterations in the mouse gut microbiota

Auteurs: Alessandra Borgognone, Aleix Elizalde-Torrent, Maria Casadellà, Luis Romero, Tuixent Escribà, Mariona Parera, Francesc Català-Moll, Marc Noguera-Julian, Christian Brander, Alex Olvera, and Roger Paredes
Publié dans: 2022
Éditeur: IHMC KOBE 2022