Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications,antimicrobial drug resistance,and unresponsiveness to therapeutic HIV-1 vaccination

Información del proyecto

MISTRAL

Identificador del acuerdo de subvención: 847943

DOI

10.3030/847943

Proyecto cerrado

Fecha de la firma de la CE 11 Diciembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 9 994 383,75

Aportación de la UE

€ 9 994 383,75

Coordinado por

FUNDACIO PRIVADA INSTITUT DE RECERCA SOBRE IMMUNOPATOLOGIES-CAIXA, IRSICAIXA
Spain

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (6)

Dissemination material: compilation of articles, flyers, brochures, posters, etc. for project diffusion v1

Compilation of dissemination material

Integrated analysis

Workplan for integrated analysis within group within each focus group

Report on the completion of ADVANZ-4 microbiome RCT

Main findings of the ADVANZ-4 microbiome clinical trial will be reported upon finalization.

Report on the completion of RECOVER RCT

The main findings of the RECOVER RCT clinical trial will be reported upon it finalization

Dissemination and communication plan

A communication plan to reach stakeholders of the project will be set out.

Handbook on management

Document to support partners in the administrative aspects related to the project.

Other (1)

EntheraMicrobiome automatized data analysis for 16s and WMGS

Enthera Web producing microbiome automatized data analysis for 16s and WMGS, minimal interface

Open Research Data Pilot (1)

Data management plan

Open Research Data Pilot deliverable. data management plan

Websites, patent fillings, videos etc. (1)

Mistral website

iVIHome will be the main communication tool of the MISTRAL project. The website will be created at the beginning of the project including not only links and documents of interest for the scientific and end user community, but also general information, written in an understandable way for non-specialist public, as well representative data and information. The website will contain both a public section and a stakeholders’ section. The public area will contain general information on the project, partners’ contact details, useful links and information on relevant microbiome portals and resources, events and workshops, project news, a download area for downloading project brochures, videos, and other useful material such as public deliverables. Partners will post news and links to the activities developed by them, as well as publications, events, tools, protocols and software used by or generated by them. Moreover, iVIHome will be an integrated, comprehensive and freely accessible repository of all HIV microbiome data generated during the MISTRAL project. It will also post news and links to the activities developed by the different institution members of the MISTRAL consortium, including publications, workshops and other outreach activities.

Publicaciones

Peer reviewed articles (19)

Spatial transcriptomics and in situ immune cell profiling of the host ectocervical landscape of HIV infected Kenyan sex working women

Autores: Mathias Franzén Boger, Vilde Kaldhusdal, Anna Pascual-Reguant, Sandy Kroh, Ralf Uecker, Adam D. Burgener, Julie Lajoie, Kenneth Omollo, Joshua Kimani, Keith R. Fowke, Anja E. Hauser, Annelie Tjernlund, Kristina Broliden
Publicado en: Frontiers in Immunology, Edición 15, 2024, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1483346

Spatial transcriptomics unveils estrogen-modulated immune responses and structural alterations in the ectocervical mucosa of depot medroxyprogesterone acetate users

Autores: Vilde Kaldhusdal, Mathias Franzen Boger, Annelie Tjernlund, Adam D. Burgener, Frideborg Bradley, Julie Lajoie, Kenneth Omollo, Joshua Kimani, Keith Fowke, Paulo Czarnewski, Kristina Broliden
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-83775-9

Impact of doxycycline pre-exposure prophylaxis (doxyPrEP) for sexually transmitted infections on the microbiome of men who have sex with men on HIV PrEP

Autores: Samantha Knodel, Leighanne Main, Marlon DeLeon, Alana Lamont, Joshua Edward, Amit K. Gupta, Laura Noel-Romas, Saira Mohammed, Tessa Tattersall, Jason Wong, Mark Hull, Troy Grennan, Adam D. Burgener
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-61426-5

Vaccination with an HIV T-cell immunogen induces alterations in the mouse gut microbiota

Autores: Alessandra Borgognone; Aleix Elizalde-Torrent; Maria Casadellà; Luis Romero; Tuixent Escribà; Mariona Parera; Francesc Català-Moll; Marc Noguera-Julian; Christian Brander; Alex Olvera; Roger Paredes
Publicado en: NPJ Biofilms Microbiomes, Edición 1, 2022, ISSN 2055-5008
Editor: Nature Publishing Group
DOI: 10.21203/rs.3.rs-1997415/v1

In vitro antibacterial activity of antiretroviral drugs on key commensal bacteria from the human microbiota

Autores: Elisa Rubio-Garcia, Núria Ferrando, Núria Martin, Clara Ballesté-Delpierre, Jose M Miró, Roger Paredes, Climent Casals-Pascual, Jordi Vila
Publicado en: Front Cell Infect Microbiol, Edición 8:13:1306430, 2024, ISSN 2235-2988
Editor: Frontiers Media S. A.
DOI: 10.3389/fcimb.2023.1306430

Impact of ChAdOx1 or DNA Prime Vaccination on Magnitude, Breadth, and Focus of MVA-Boosted Immunogen-Specific T Cell Responses

Autores: Alex Olvera, Luis Romero-Martin, Bruna Oriol-Tordera, Miriam Rosas-Umbert, Tuixent Escribà, Beatriz Mothe, Christian Brander
Publicado en: Vaccines, Edición 12(3), 279, 7 March 2024, 2024, Página(s) 1 to 16, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines12030279

Vaccination with an HIV T-Cell Immunogen (HTI) Using DNA Primes Followed by a ChAdOx1-MVA Boost Is Immunogenic in Gut Microbiota-Depleted Mice despite Low IL-22 Serum Levels

Autores: Aleix Elizalde-Torrent, Alessandra Borgognone, Maria Casadellà, Luis Romero-Martin, Tuixent Escribà, Mariona Parera, Yaiza Rosales-Salgado, Jorge Díaz-Pedroza, Francesc Català-Moll, Marc Noguera-Julian, Christian Brander, Roger Paredes, Alex Olvera
Publicado en: Vaccines, Edición 11(11), 1663, 30 October 2023, 2023, Página(s) 1 to 17, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11111663

Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial

Autores: Bailón L, Llano A, Cedeño S et al; and AELIX002 Study Group
Publicado en: Nature Medicine, 2022, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-022-02060-2

The cervicovaginal microbiome associates with spatially restricted host transcriptional signatures throughout the human ectocervical epithelium and submucosa

Autores: Vilde Kaldhusdal, Mathias Franzén Boger, Adam D. Burgener, Julie Lajoie, Kenneth Omollo, Joshua Kimani, Annelie Tjernlund, Keith R. Fowke, Douglas S. Kwon, Gabriella Edfeldt, Kristina Broliden
Publicado en: PLOS Pathogens, Edición 21, 2025, Página(s) e1013677, ISSN 1553-7374
Editor: Public Library of Science (PLoS)
DOI: 10.1371/journal.ppat.1013677

Probiotic effects on immunity and microbiome in HIV-1 discordant patients

Autores: Carlos Blázquez-Bondia; Mariona Parera; Francesc Català-Moll; Maria Casadellà; Aleix Elizalde-Torrent; Meritxell Aguiló; Jordi Espadaler-Mazo; José Ramon Santos; Roger Paredes; Marc Noguera-Julian
Publicado en: Frontiers in Immunology, Edición 1, 2022, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2022.1066036

Dolutegravir restores gut microbiota in late-stage HIV-1 unlike darunavir: an open-label, randomized clinical trial

Autores: Francesc Català-Moll, Carlos Blázquez-Bondia, Judit Farré-Badia, Ferran Torres, Christian Manzardo, Eva Bonfill, Adrià Curran, Pere Domingo, Daniel Podzamczer, Lluís Force, Vicenç Falcó, Mariona Parera, Maria Casadellà, José Maria Miró, Marc Noguera-Julian, Roger Paredes, null null, null null, Alessandra Borgognone, Nel Marín, Oriol Careta, Valentina Triviño, null null, Anna Cruceta, N
Publicado en: Nature Communications, Edición 17, 2026, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-026-69846-7

Interactions between gut microbiota, plasma metabolome and brain function in the setting of a HIV cure trial

Autores: Alessandra Borgognone, Anna Prats, Ashish Arunkumar Sharma, Ignacio Martinez-Zalacaín, Carles Soriano-Mas, Christian Brander, Bonaventura Clotet, José Moltó, Beatriz Mothe, Rafick-Pierre Sekaly, Roger Paredes, Jose A. Muñoz-Moreno
Publicado en: Frontiers in Cellular and Infection Microbiology, Edición 15, 2025, ISSN 2235-2988
Editor: Frontiers Media S. A.
DOI: 10.3389/fcimb.2025.1629901

Exploring potential associations between the human microbiota and reservoir of latent HIV

Autores: Nel Marín-Sánchez, Roger Paredes, Alessandra Borgognone
Publicado en: Retrovirology, Edición 21, 2024, ISSN 1742-4690
Editor: BioMed Central
DOI: 10.1186/s12977-024-00655-w

Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome

Autores: Bruna Oriol-Tordera, Anna Esteve-Codina, María Berdasco, Míriam Rosás-Umbert, Elena Gonçalves, Clara Duran-Castells, Francesc Català-Moll, Anuska Llano, Samandhy Cedeño, Maria C. Puertas, Martin Tolstrup, Ole S. Søgaard, Bonaventura Clotet, Javier Martínez-Picado, Tomáš Hanke, Behazine Combadiere, Roger Paredes, Dennis Hartigan-O'Connor, Manel Esteller, Michael Meulbroek, María Luz Call
Publicado en: eBioMedicine, Edición 78, 2023, Página(s) 103956, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2022.103956

Host Transcriptome and Microbiota Signatures Prior to Immunization Profile Vaccine Humoral Responsiveness

Autores: Elena Gonçalves, Yolanda Guillén, Javier R. Lama, Jorge Sanchez, Christian Brander, Roger Paredes, Behazine Combadière
Publicado en: Frontiers in Immunology, Edición 12, 2021, ISSN 1664-3224
Editor: Lausanne: Frontiers Media S.A
DOI: 10.3389/fimmu.2021.657162

Gut resistome linked to sexual preference and HIV infection

Autores: Elisa Rubio Garcia, Maria Casadellà, Mariona Parera, Jordi Vila, Roger Paredes, and Marc Noguera-Julian
Publicado en: BMC Microbiol., Edición 2024; 24: 201, 2024, ISSN 1471-2180
Editor: BioMed Central
DOI: 10.1186/s12866-024-03335-z

Estradiol-mediated enhancement of the human ectocervical epithelial barrier correlates with desmoglein-1 expression in the follicular menstrual phase

Autores: Frideborg Bradley, Alexandra Stern, Mathias Franzén Boger, Zaynab Mousavian, Olga Dethlefsen, Vilde Kaldhusdal, Julie Lajoie, Kenneth Omollo, Sofia Bergström, Anna Månberg, Peter Nilsson, Joshua Kimani, Adam D. Burgener, Annelie Tjernlund, Christopher Sundling, Keith R. Fowke, Kristina Broliden
Publicado en: Frontiers in Endocrinology, Edición 15, 2024, ISSN 1664-2392
Editor: Frontiers Media SA
DOI: 10.3389/fendo.2024.1454006

Gut microbiome signatures linked to HIV-1 reservoir size and viremia control

Autores: Alessandra Borgognone; Bruna Oriol-Tordera; Beatriz Mothe; Roger Paredes; Maria C. Puertas
Publicado en: Microbiome, Edición 3, 2022, ISSN 2049-2618
Editor: Springer Nature
DOI: 10.1186/s40168-022-01247-6

Immune reconstitution in very advanced HIV patients treated with dolutegravir vs. darunavir-based triple antiretroviral therapy: the Advanz-4 randomized clinical trial

Autores: Jose M. Miro, Ferran Torres, Christian Manzardo, Eva Bonfill, Adrià Curran, Pere Domingo, Daniel Podzamczer, Roger Paredes, Lluis Force, Vicenç Falco, Mar Gutierrez, Maria Saumoy, Anna Castelli, Alexy Inciarte, Cristina Rovira, Anna Cruceta, Carmen Hurtado, Núria Climent, Francisco Lozano, Montserrat Plana, Jose M. Miro, Ferran Torres, Christian Manzardo, Eva Bonfill, Anna Cruceta, Núria Clime
Publicado en: Clinical Microbiology and Infection, Edición 32, 2026, Página(s) 169-176, ISSN 1198-743X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2025.09.026

Other (4)

B-Cell Gene Expression and Microbiota Prior Immunization Profile Vaccine Humoral Responsiveness

Autores: Elena Gonçalves, Yolanda Guillén, Javier R Lama, Jorge Sanchez, Christian Brander, Roger Paredes, Behazine Combadière
Publicado en: 2021
Editor: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-46833/v1

IN_CERT Programme

Autores: Mercè Pomer; Queralt Morros; Roger Paredes; Cristina Vilaplana; Lourdes Mateu; Manel Guerrero; Jo Milne; Nora Ancarola; Adolf Alcañiz
Publicado en: Projecte IN_CERT. Art, Ciència i Pensament des de la Pandèmia, Edición 1, 2021
Editor: Ajuntament d'Alella
DOI: 10.5281/zenodo.5608507

Probiotic effects on immunity and microbiome in HIV-1 discordant patients

Autores: Blázquez-Bondia, Carlos; Parera, Mariona; Català-Moll, Francesc; Casadellà, Maria; Elizalde-Torrent, Aleix; Aguiló, Meritxell; Espadaler Mazo, Jordi; Santos, José Ramon; Paredes, Roger; Noguera-Julian, Marc; Universitat Autònoma de Barcelona
Publicado en: Edición 3, 2022
Editor: https://ddd.uab.cat/record/281731

Vaccination with an HIV T-Cell Immunogen (HTI) Using DNA Primes Followed by a ChAdOx1-MVA Boost Is Immunogenic in Gut Microbiota-Depleted Mice despite Low IL-22 Serum Levels

Autores: Elizalde-Torrent, Aleix; Borgognone, Alessandra; Casadellà, Maria; Romero-Martín, Luis; Escribà, Tuixent; Parera, Mariona; Rosales-Salgado, Yaiza; Díaz-Pedroza, Jorge; Català-Moll, Francesc; Noguera-Julian, Marc; Brander, Christian; Paredes, Roger; Olvera, Alex; Universitat Autònoma de Barcelona
Publicado en: https://ddd.uab.cat/record/294075, Edición 2, 2023
Editor: https://ddd.uab.cat/record/294075

Conference proceedings (5)

RECOVER: Immune reconstitution with synbiotics in HIV-1 infected immunodiscordant patients

Autores: Carlos Blázquez-Bondia, Mariona Parera, Francesc Català-Moll, Maria Casadellà, Aleix Elizalde-Torrent, Meritxell Aguilo, Jordi Espadaler-Mazo, José Ramon Santos, Roger Paredes and Marc Noguera-Julian
Publicado en: 2022
Editor: IHMC KOBE 2022

Repurposing Elvitegravir as a novel antibiotic against multidrug-resistant Gram-positive bacteria

Autores: Núria Martín et al
Publicado en: Flash sessions ECCMID 2024 BCN, 2024
Editor: ECCMID 2024 BCN

Consensus-based robustness for differential abundance testing in microbiome data analysis

Autores: Francesc Català-Moll, Roger Paredes, Marc Noguera-Julian
Publicado en: 2022
Editor: IHMC KOBE 2022

A placebo-controlled ATI trial of HTI vaccines in early treated HIV infection

Autores: Bailón L, Llano A, Cedeño S et al; and AELIX002 Study Group
Publicado en: Topics in Antiviral Medicine. Special Edición: Abstracts from the 21 Virtual Conference on Retroviruses and Opportunistic Infections (CROI), Edición Volume 29, Edición 1, March 2021, 2021, Página(s) Abstract NR 161
Editor: Abstracts from the 21 Virtual Conference on Retroviruses and Opportunistic Infections (CROI)

Vaccination with an HIV T-cell immunogen induces alterations in the mouse gut microbiota

Autores: Alessandra Borgognone, Aleix Elizalde-Torrent, Maria Casadellà, Luis Romero, Tuixent Escribà, Mariona Parera, Francesc Català-Moll, Marc Noguera-Julian, Christian Brander, Alex Olvera, and Roger Paredes
Publicado en: 2022
Editor: IHMC KOBE 2022