DECOMPENSATED CIRRHOSIS: IDENTIFICATION OF NEW COMBINATORIAL THERAPIES BASED ON SYSTEMS APPROACHES

Project Information

DECISION

Grant agreement ID: 847949

DOI

10.3030/847949

EC signature date 5 December 2019

Start date 1 April 2020

End date 31 March 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 6 000 007,13

EU contribution

€ 6 000 000,00

Coordinated by

EUROPEAN FOUNDATION FOR THE STUDY OF CHRONIC LIVER FAILURE (EF-CLIF)
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (3)

Second patient and layman event

ELPA will organize an event aimed at patients and the general public to increase awareness of patients and the general public for cirrhosis and related complications and potential new therapies

Go-online of the public project website

The DECISION website will go live with information on the project on the partners on the disease and it will offer public results for download and references to publications

First patient and layman event

ELPA will organize an event aimed at patients and the general public to increase awareness of patients and the general public for cirrhosis and related complications and potential new therapies

Documents, reports (6)

Public engagement strategy to design DECISION along with the need of patients

This document will define the DECISION public engagement strategy in an ethically and legally sound way and build the basis for D72

Codes of conduct applicable and research integrity policy including publications in journals

Definition of the DECISION Code of conduct and research integrity policy for research undertaken in DECISION and publication of results

Checklist for participants to assure informed consent / other mechanisms for those unable to give a written consent

Checklist for informed consent procedures for people unable to give written consent

First written draft of a model describing typical treatment paths in decompensated cirrhosis

Health economic model for treatment paths in decompensated cirrhosis

Project brochure and professional templates

The project flyer will give information on the project and contact details for distribution at conferences A professionally designed poster and PPt template will guarantee growing recognition of the project

Generation of rat models of acute decompensation of cirrhosis developing ACLF

Performing the described models of cirrhosis with the respective triggers of ACLF

Data sets, microdata, etc (2)

Deposit of genotyping data (n=2200) to European Variation Archive (EVA) (EMBL)

Deposit of the raw data of DNA genotyping in an open-based publicly-owned database.

Deposit of transcriptomics data (n=1400) to Gene Expression Omnibus (GEO) (NCBI)

Deposit of the raw data of RNAseq transcripts in open-based publicly-owned database.

Publications

Peer reviewed articles (42)

Prognosis algorithms for acute decompensation of cirrhosis and <scp>ACLF</scp>

Author(s): Shantha R. Valainathan, Qing Xie, Vicente Arroyo, Pierre‐Emmanuel Rautou
Published in: Liver International, 2024, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.15927

Acute and non‐acute decompensation of liver cirrhosis (47/130)

Author(s): Martin S. Schulz, Paolo Angeli, Jonel Trebicka
Published in: Liver International, 2024, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.15861

Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction.

Author(s): Engelmann C, Clària J, Szabo G, Bosch J, Bernardi M.
Published in: J Hepatol., 2021, ISSN 1600-0641
Publisher: Elsevier
DOI: 10.1016/j.jhep.2021.01.002

Mechanisms of immunity in acutely decompensated cirrhosis and acute‐on‐chronic liver failure

Author(s): Cornelius Engelmann, Ingrid W. Zhang, Joan Clària
Published in: Liver International, 2023, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.15644

Roles of systemic inflammatory and metabolic responses in the pathophysiology of acute-on-chronic liver failure

Author(s): Joan Clària, Vicente Arroyo, Richard Moreau
Published in: JHEP Reports, Issue 5, 2024, Page(s) 100807, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2023.100807

Preoperative TIPS prevents the development of postoperative acute-on-chronic liver failure in patients with high CLIF-C AD score.

Author(s): Chang J, Höfer P, Böhling N, et al.
Published in: JHEP Rep., 2022, ISSN 2589-5559
Publisher: BMJ Journals
DOI: 10.1016/j.jhepr.2022.100442

Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure.

Author(s): Zhang IW, Curto A, López-Vicario C, et al.
Published in: J Hepatol., 2022, ISSN 1600-0641
Publisher: Elsevier
DOI: 10.1016/j.jhep.2021.08.009

Untargeted lipidomics uncovers lipid signatures that distinguish severe from moderate forms of acutely decompensated cirrhosis

Author(s): Clària J, Curto A, Moreau R, et al.
Published in: J Hepatol., 2021, ISSN 1600-0641
Publisher: Elsevier
DOI: 10.1016/j.jhep.2021.06.043

To TIPS or Not to TIPS in High Risk of Variceal Rebleeding and Acute-on-Chronic Liver Failure

Author(s): Wenyi Gu, Markus Kimmann, Wim Laleman, Michael Praktiknjo, Jonel Trebicka
Published in: Seminars in Liver Disease, Issue 43, 2023, Page(s) 189-205, ISSN 0272-8087
Publisher: Thieme Medical Publishers
DOI: 10.1055/a-2107-0576

Trends and the course of liver cirrhosis and its complications in Germany: Nationwide population-based study (2005 to 2018).

Author(s): Gu W, Hortlik H, Erasmus HP, et al.
Published in: Lancet Reg Health Eur., 2021, ISSN 2666-7762
Publisher: Elsevier
DOI: 10.1016/j.lanepe.2021.100240

Baveno VII Faculty. Baveno VII - Renewing consensus in portal hypertension

Author(s): de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C;
Published in: J Hepatol., 2022, ISSN 1600-0641
Publisher: Elsevier
DOI: 10.1016/j.jhep.2021.12.022

Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure

Author(s): Robert Schierwagen, Wenyi Gu, Angela Brieger, Bernhard Brüne, Sandra Ciesek, Ivan Đikić, Stefanie Dimmeler, Gerd Geisslinger, Florian R. Greten, Eva Hermann, Eberhard Hildt, Volkhard A. J. Kempf, Sabine Klein, Ina Koch, Heiko Mühl, Volker Müller, Kai-Henrik Peiffer, Roxane-Isabelle Kestner, Albrecht Piiper, Gernot Rohde, Klaus Scholich, Marcel H. Schulz, Holger Storf, Tuna Toptan, Mariuca Vas
Published in: American Journal of Physiology-Cell Physiology, Issue 325, 2024, Page(s) C129-C140, ISSN 0363-6143
Publisher: American Physiological Society
DOI: 10.1152/ajpcell.00101.2023

Leveraging omics to understand the molecular basis of acute-on-chronic liver failure

Author(s): Joan Clària
Published in: instname:Universidad de Barcelona, Issue 1, 2021, ISSN 2628-491X
Publisher: De Gruyter
DOI: 10.1515/almed-2021-0023

Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease.

Author(s): Trebicka J, Gu W, de Ledinghen V, et al.
Published in: Gut, 2022, ISSN 1468-3288
Publisher: BMJ
DOI: 10.1136/gutjnl-2020-323419

Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study

Author(s): Buch S, Innes H, Lutz PL, et al.
Published in: Gut, 2023, ISSN 1468-3288
Publisher: BMJ Journals
DOI: 10.1136/gutjnl-2022-327196

The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis

Author(s): Innes H, Nischalke HD, Guha IN, et al.
Published in: Hepatol Commun., 2022, ISSN 2471-254X
Publisher: Wolters Kluwer
DOI: 10.1002/hep4.1886

Essential role for albumin in preserving liver cells from TNFα-induced mitochondrial injury

Author(s): Duran-Güell M, Garrabou G, Flores-Costa R, et al.
Published in: FASEB J, 2023, ISSN 1530-6860
Publisher: Wiley
DOI: 10.1096/fj.202201526r

Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators.

Author(s): Sánchez-Rodríguez MB, Téllez É, Casulleras M, et al.
Published in: Front Immunol., 2022, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.842996

A robust clustering strategy for stratification unveils unique patient subgroups in acutely decompensated cirrhosis

Author(s): Sara Palomino-Echeverria, Estefania Huergo, Asier Ortega-Legarreta, Eva M. Uson Raposo, Ferran Aguilar, Carlos de la Peña-Ramirez, Cristina López-Vicario, Carlo Alessandria, Wim Laleman, Alberto Queiroz Farias, Richard Moreau, Javier Fernandez, Vicente Arroyo, Paolo Caraceni, Vincenzo Lagani, Cristina Sánchez-Garrido, Joan Clària, Jesper Tegner, Jonel Trebicka, Narsis A. Kiani, Nuria Planell,
Published in: Journal of Translational Medicine, Issue 22, 2024, ISSN 1479-5876
Publisher: BioMed Central
DOI: 10.1186/s12967-024-05386-2

Stratifying the risk of NAFLD in patients with HIV under combination antiretroviral therapy (cART).

Author(s): Bischoff J, Gu W, Schwarze-Zander C, et al.
Published in: EClinicalMedicine., 2021, ISSN 2589-5370
Publisher: Elsevier
DOI: 10.1016/j.eclinm.2021.101116

redicting bleeding after liver biopsy using comprehensive clinical and laboratory investigations: A prospective analysis of 302 procedures

Author(s): Bissonnette J, Riescher-Tuczkiewicz A, Gigante E, et al.
Published in: J Thromb Haemost., 2022, ISSN 1538-7836
Publisher: John Wiley
DOI: 10.1111/jth.15888

Restoration of the gut microbiota is associated with a decreased risk of hepatic encephalopathy after TIPS

Author(s): Li M, Li K, Tang S, et al.
Published in: JHEP Rep., 2022, ISSN 2589-5559
Publisher: ELSEVIER
DOI: 10.1016/j.jhepr.2022.100448

Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure

Author(s): Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U. Macías-Rodríguez, Astrid Ruiz-Margáin, Robert Schierwagen, Hui Liu, Chen Shao, Chunlei Fan, Rilu Feng, Xiaodong Yuan, Sai Wang, Franziska Wandrer, Christoph Meyer, Ralf Wimmer, Roman Liebe, Jens Kroll, Long Zhang, Tobias Schiergens, Peter ten Dijke, Andreas Teufel, Alexander Marx, Peter R. Mertens, Hua Wang, Matthias P.A. Ebert,
Published in: Hepatology, 2022, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.32119

Leukocytes, Systemic Inflammation and Immunopathology in Acute-on-Chronic Liver Failure

Author(s): Mireia Casulleras, Ingrid W. Zhang, Cristina López-Vicario, Joan Clària
Published in: Cells, Issue 9, 2024, Page(s) 2632, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9122632

Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction

Author(s): Tilman Sauerbruch, Martin Hennenberg, Jonel Trebicka, Ulrich Beuers
Published in: Frontiers in Physiology, Issue 12, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.718783

Proresolving lipid mediators and liver disease.

Author(s): Clària J, Flores-Costa R, Duran-Güell M, López-Vicario C.
Published in: Biochim Biophys Acta Mol Cell Biol Lipids., 2021, ISSN 1879-2618
Publisher: Frontiers
DOI: 10.1016/j.bbalip.2021.159023

Early transplantation maximizes survival in severe acute-on-chronic liver failure: Results of a Markov decision process model.

Author(s): Zhang S, Suen SC, Gong CL, et al.
Published in: JHEP Rep., 2021, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2021.100367

Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis.

Author(s): Reiniš J, Petrenko O, Simbrunner B, et al.
Published in: J Hepatol., 2023, ISSN 1600-0641
Publisher: Elsevier
DOI: 10.1016/j.jhep.2022.09.012

Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis.

Author(s): Tantai X, Liu Y, Yeo YH, et al.
Published in: J Hepatol., Issue Elsevier, 2022, Page(s) N/A, ISSN 1600-0641
Publisher: Elsevier
DOI: 10.1016/j.jhep.2021.11.006

Albumin protects the liver from tumor necrosis factor α-induced immunopathology.

Author(s): Duran-Güell, M, Flores-Costa, R, Casulleras, M, et al.
Published in: The FASEB Journal, 2021, ISSN 1530-6860
Publisher: Wiley
DOI: 10.1096/fj.202001615rrr

Editorial: Acute-on-chronic liver failure: systemic inflammation and immunosuppression

Author(s): Olaf Tyc, Yu Shi, Yu-Chen Fan, Jonel Trebicka, Xiaogang Xiang
Published in: Frontiers in Immunology, Issue 14, 2023, ISSN 1664-3224
Publisher: International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2023.1260749

Management of splanchnic vein thrombosis.

Author(s): Elkrief L, Payancé A, Plessier A, et al.
Published in: JHEP Rep., 2023, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2022.100667

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction-associated fatty liver disease.

Author(s): López-Vicario C, Sebastián D, Casulleras M, et al.
Published in: Hepatology, 2023, ISSN 1527-3350
Publisher: AALSD
DOI: 10.1002/hep.32647

Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis

Author(s): Adrià Juanola, Ann Thu Ma, Koos de Wit, Kohilan Gananandan, Olivier Roux, Giacomo Zaccherini, César Jiménez, Marta Tonon, Cristina Solé, Clara Villaseca, Frank E Uschner, Isabel Graupera, Elisa Pose, Maria José Moreta, Daniela Campion, Ulrich Beuers, Rajeshawar P Mookerjee, Claire Francoz, Francois Durand, Victor Vargas, Salvatore Piano, Sonia Alonso, Jonel Trebicka, Wim Laleman, Sumeet K Asr
Published in: Gut, Issue 73, 2024, Page(s) 156-165, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-329923

Controversies regarding albumin therapy in cirrhosis

Author(s): Jonel Trebicka, Guadalupe Garcia-Tsao
Published in: Hepatology, 2024, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000521

Mitochondrial Dysfunction in Advanced Liver Disease: Emerging Concepts.

Author(s): Zhang IW, López-Vicario C, Duran-Güell M, Clària J.
Published in: Front Mol Biosci., 2021, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2021.772174

Recent advances in the prevention and treatment of decompensated cirrhosis and acute-on-chronic liver failure (ACLF) and the role of biomarkers

Author(s): Jonel Trebicka, Ruben Hernaez, Debbie Lindsay Shawcross, Alexander L Gerbes
Published in: Gut, Issue 73, 2024, Page(s) 1015-1024, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-330584

Editorial: Portal Hypertension in Cirrhosis: From Pathogenesis to Novel Treatments

Author(s): Herath CB, Angus PW, Trebicka J.
Published in: Front Physiol., 2022, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.864083

Acute-On-Chronic Liver Failure: Current Interventional Treatment Options and Future Challenges

Author(s): Markus Kimmann, Jonel Trebicka
Published in: Journal of Personalized Medicine, Issue 13, 2024, Page(s) 1052, ISSN 2075-4426
Publisher: MPDI
DOI: 10.3390/jpm13071052

Autophagy-Related Activation of Hepatic Stellate Cells Reduces Cellular miR-29a by Promoting Its Vesicular Secretion.

Author(s): Yu X, Elfimova N, Müller M, et al.
Published in: Cell Mol Gastroenterol Hepatol., 2022, ISSN 2352-345X
Publisher: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2022.02.013

Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models.

Author(s): Johannes Chang; Jonathan Meinke; Moritz Geck; Marc Hebest; Nina Böhling; Ramona Dolscheid-Pommerich; Birgit Stoffel-Wagner; Glen Kristiansen; Marcus Overhaus; Leon O. Peyman; Sabine Klein; Frank E. Uschner; Maximilian J. Brol; Tim O. Vilz; Philipp Lingohr; Jörg C. Kalff; Christian Jansen; Christian P. Strassburg; Sven Wehner; Jonel Trebicka; Jonel Trebicka; Michael Praktiknjo
Published in: Frontiers in Physiology, Issue 1, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.720898

Acute-on-chronic liver failure: a global disease

Author(s): Schulz M, Trebicka J.
Published in: Gut, 2021, ISSN 1468-3288
Publisher: BMJ
DOI: 10.1136/gutjnl-2020-323973

Monographic books (1)

Guidelines for reviewing health research and innovation that use emergent technologies and personal data

Author(s): De Lecuona, I
Published in: 2020, ISBN 978-84-9168-646-0
Publisher: Edicions de la Universitat de Barcelona