DECOMPENSATED CIRRHOSIS: IDENTIFICATION OF NEW COMBINATORIAL THERAPIES BASED ON SYSTEMS APPROACHES

Informations projet

DECISION

N° de convention de subvention: 847949

DOI

10.3030/847949

Date de signature de la CE 5 Decembre 2019

Date de début 1 Avril 2020

Date de fin 31 Mars 2026

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 6 000 007,13

Contribution de l’UE

€ 6 000 000,00

Coordonné par

EUROPEAN FOUNDATION FOR THE STUDY OF CHRONIC LIVER FAILURE (EF-CLIF)
Spain

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (3)

Second patient and layman event

ELPA will organize an event aimed at patients and the general public to increase awareness of patients and the general public for cirrhosis and related complications and potential new therapies

Go-online of the public project website

The DECISION website will go live with information on the project on the partners on the disease and it will offer public results for download and references to publications

First patient and layman event

ELPA will organize an event aimed at patients and the general public to increase awareness of patients and the general public for cirrhosis and related complications and potential new therapies

Documents, reports (6)

Public engagement strategy to design DECISION along with the need of patients

This document will define the DECISION public engagement strategy in an ethically and legally sound way and build the basis for D72

Codes of conduct applicable and research integrity policy including publications in journals

Definition of the DECISION Code of conduct and research integrity policy for research undertaken in DECISION and publication of results

Checklist for participants to assure informed consent / other mechanisms for those unable to give a written consent

Checklist for informed consent procedures for people unable to give written consent

First written draft of a model describing typical treatment paths in decompensated cirrhosis

Health economic model for treatment paths in decompensated cirrhosis

Project brochure and professional templates

The project flyer will give information on the project and contact details for distribution at conferences A professionally designed poster and PPt template will guarantee growing recognition of the project

Generation of rat models of acute decompensation of cirrhosis developing ACLF

Performing the described models of cirrhosis with the respective triggers of ACLF

Data sets, microdata, etc (2)

Deposit of genotyping data (n=2200) to European Variation Archive (EVA) (EMBL)

Deposit of the raw data of DNA genotyping in an open-based publicly-owned database.

Deposit of transcriptomics data (n=1400) to Gene Expression Omnibus (GEO) (NCBI)

Deposit of the raw data of RNAseq transcripts in open-based publicly-owned database.

Publications

Peer reviewed articles (42)

Prognosis algorithms for acute decompensation of cirrhosis and <scp>ACLF</scp>

Auteurs: Shantha R. Valainathan, Qing Xie, Vicente Arroyo, Pierre‐Emmanuel Rautou
Publié dans: Liver International, 2024, ISSN 1478-3223
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/liv.15927

Acute and non‐acute decompensation of liver cirrhosis (47/130)

Auteurs: Martin S. Schulz, Paolo Angeli, Jonel Trebicka
Publié dans: Liver International, 2024, ISSN 1478-3223
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/liv.15861

Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction.

Auteurs: Engelmann C, Clària J, Szabo G, Bosch J, Bernardi M.
Publié dans: J Hepatol., 2021, ISSN 1600-0641
Éditeur: Elsevier
DOI: 10.1016/j.jhep.2021.01.002

Mechanisms of immunity in acutely decompensated cirrhosis and acute‐on‐chronic liver failure

Auteurs: Cornelius Engelmann, Ingrid W. Zhang, Joan Clària
Publié dans: Liver International, 2023, ISSN 1478-3223
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/liv.15644

Roles of systemic inflammatory and metabolic responses in the pathophysiology of acute-on-chronic liver failure

Auteurs: Joan Clària, Vicente Arroyo, Richard Moreau
Publié dans: JHEP Reports, Numéro 5, 2024, Page(s) 100807, ISSN 2589-5559
Éditeur: Elsevier
DOI: 10.1016/j.jhepr.2023.100807

Preoperative TIPS prevents the development of postoperative acute-on-chronic liver failure in patients with high CLIF-C AD score.

Auteurs: Chang J, Höfer P, Böhling N, et al.
Publié dans: JHEP Rep., 2022, ISSN 2589-5559
Éditeur: BMJ Journals
DOI: 10.1016/j.jhepr.2022.100442

Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure.

Auteurs: Zhang IW, Curto A, López-Vicario C, et al.
Publié dans: J Hepatol., 2022, ISSN 1600-0641
Éditeur: Elsevier
DOI: 10.1016/j.jhep.2021.08.009

Untargeted lipidomics uncovers lipid signatures that distinguish severe from moderate forms of acutely decompensated cirrhosis

Auteurs: Clària J, Curto A, Moreau R, et al.
Publié dans: J Hepatol., 2021, ISSN 1600-0641
Éditeur: Elsevier
DOI: 10.1016/j.jhep.2021.06.043

To TIPS or Not to TIPS in High Risk of Variceal Rebleeding and Acute-on-Chronic Liver Failure

Auteurs: Wenyi Gu, Markus Kimmann, Wim Laleman, Michael Praktiknjo, Jonel Trebicka
Publié dans: Seminars in Liver Disease, Numéro 43, 2023, Page(s) 189-205, ISSN 0272-8087
Éditeur: Thieme Medical Publishers
DOI: 10.1055/a-2107-0576

Trends and the course of liver cirrhosis and its complications in Germany: Nationwide population-based study (2005 to 2018).

Auteurs: Gu W, Hortlik H, Erasmus HP, et al.
Publié dans: Lancet Reg Health Eur., 2021, ISSN 2666-7762
Éditeur: Elsevier
DOI: 10.1016/j.lanepe.2021.100240

Baveno VII Faculty. Baveno VII - Renewing consensus in portal hypertension

Auteurs: de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C;
Publié dans: J Hepatol., 2022, ISSN 1600-0641
Éditeur: Elsevier
DOI: 10.1016/j.jhep.2021.12.022

Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure

Auteurs: Robert Schierwagen, Wenyi Gu, Angela Brieger, Bernhard Brüne, Sandra Ciesek, Ivan Đikić, Stefanie Dimmeler, Gerd Geisslinger, Florian R. Greten, Eva Hermann, Eberhard Hildt, Volkhard A. J. Kempf, Sabine Klein, Ina Koch, Heiko Mühl, Volker Müller, Kai-Henrik Peiffer, Roxane-Isabelle Kestner, Albrecht Piiper, Gernot Rohde, Klaus Scholich, Marcel H. Schulz, Holger Storf, Tuna Toptan, Mariuca Vas
Publié dans: American Journal of Physiology-Cell Physiology, Numéro 325, 2024, Page(s) C129-C140, ISSN 0363-6143
Éditeur: American Physiological Society
DOI: 10.1152/ajpcell.00101.2023

Leveraging omics to understand the molecular basis of acute-on-chronic liver failure

Auteurs: Joan Clària
Publié dans: instname:Universidad de Barcelona, Numéro 1, 2021, ISSN 2628-491X
Éditeur: De Gruyter
DOI: 10.1515/almed-2021-0023

Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease.

Auteurs: Trebicka J, Gu W, de Ledinghen V, et al.
Publié dans: Gut, 2022, ISSN 1468-3288
Éditeur: BMJ
DOI: 10.1136/gutjnl-2020-323419

Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study

Auteurs: Buch S, Innes H, Lutz PL, et al.
Publié dans: Gut, 2023, ISSN 1468-3288
Éditeur: BMJ Journals
DOI: 10.1136/gutjnl-2022-327196

The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis

Auteurs: Innes H, Nischalke HD, Guha IN, et al.
Publié dans: Hepatol Commun., 2022, ISSN 2471-254X
Éditeur: Wolters Kluwer
DOI: 10.1002/hep4.1886

Essential role for albumin in preserving liver cells from TNFα-induced mitochondrial injury

Auteurs: Duran-Güell M, Garrabou G, Flores-Costa R, et al.
Publié dans: FASEB J, 2023, ISSN 1530-6860
Éditeur: Wiley
DOI: 10.1096/fj.202201526r

Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators.

Auteurs: Sánchez-Rodríguez MB, Téllez É, Casulleras M, et al.
Publié dans: Front Immunol., 2022, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2022.842996

A robust clustering strategy for stratification unveils unique patient subgroups in acutely decompensated cirrhosis

Auteurs: Sara Palomino-Echeverria, Estefania Huergo, Asier Ortega-Legarreta, Eva M. Uson Raposo, Ferran Aguilar, Carlos de la Peña-Ramirez, Cristina López-Vicario, Carlo Alessandria, Wim Laleman, Alberto Queiroz Farias, Richard Moreau, Javier Fernandez, Vicente Arroyo, Paolo Caraceni, Vincenzo Lagani, Cristina Sánchez-Garrido, Joan Clària, Jesper Tegner, Jonel Trebicka, Narsis A. Kiani, Nuria Planell,
Publié dans: Journal of Translational Medicine, Numéro 22, 2024, ISSN 1479-5876
Éditeur: BioMed Central
DOI: 10.1186/s12967-024-05386-2

Stratifying the risk of NAFLD in patients with HIV under combination antiretroviral therapy (cART).

Auteurs: Bischoff J, Gu W, Schwarze-Zander C, et al.
Publié dans: EClinicalMedicine., 2021, ISSN 2589-5370
Éditeur: Elsevier
DOI: 10.1016/j.eclinm.2021.101116

redicting bleeding after liver biopsy using comprehensive clinical and laboratory investigations: A prospective analysis of 302 procedures

Auteurs: Bissonnette J, Riescher-Tuczkiewicz A, Gigante E, et al.
Publié dans: J Thromb Haemost., 2022, ISSN 1538-7836
Éditeur: John Wiley
DOI: 10.1111/jth.15888

Restoration of the gut microbiota is associated with a decreased risk of hepatic encephalopathy after TIPS

Auteurs: Li M, Li K, Tang S, et al.
Publié dans: JHEP Rep., 2022, ISSN 2589-5559
Éditeur: ELSEVIER
DOI: 10.1016/j.jhepr.2022.100448

Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure

Auteurs: Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U. Macías-Rodríguez, Astrid Ruiz-Margáin, Robert Schierwagen, Hui Liu, Chen Shao, Chunlei Fan, Rilu Feng, Xiaodong Yuan, Sai Wang, Franziska Wandrer, Christoph Meyer, Ralf Wimmer, Roman Liebe, Jens Kroll, Long Zhang, Tobias Schiergens, Peter ten Dijke, Andreas Teufel, Alexander Marx, Peter R. Mertens, Hua Wang, Matthias P.A. Ebert,
Publié dans: Hepatology, 2022, ISSN 0270-9139
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/hep.32119

Leukocytes, Systemic Inflammation and Immunopathology in Acute-on-Chronic Liver Failure

Auteurs: Mireia Casulleras, Ingrid W. Zhang, Cristina López-Vicario, Joan Clària
Publié dans: Cells, Numéro 9, 2024, Page(s) 2632, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells9122632

Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction

Auteurs: Tilman Sauerbruch, Martin Hennenberg, Jonel Trebicka, Ulrich Beuers
Publié dans: Frontiers in Physiology, Numéro 12, 2021, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.718783

Proresolving lipid mediators and liver disease.

Auteurs: Clària J, Flores-Costa R, Duran-Güell M, López-Vicario C.
Publié dans: Biochim Biophys Acta Mol Cell Biol Lipids., 2021, ISSN 1879-2618
Éditeur: Frontiers
DOI: 10.1016/j.bbalip.2021.159023

Early transplantation maximizes survival in severe acute-on-chronic liver failure: Results of a Markov decision process model.

Auteurs: Zhang S, Suen SC, Gong CL, et al.
Publié dans: JHEP Rep., 2021, ISSN 2589-5559
Éditeur: Elsevier
DOI: 10.1016/j.jhepr.2021.100367

Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis.

Auteurs: Reiniš J, Petrenko O, Simbrunner B, et al.
Publié dans: J Hepatol., 2023, ISSN 1600-0641
Éditeur: Elsevier
DOI: 10.1016/j.jhep.2022.09.012

Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis.

Auteurs: Tantai X, Liu Y, Yeo YH, et al.
Publié dans: J Hepatol., Numéro Elsevier, 2022, Page(s) N/A, ISSN 1600-0641
Éditeur: Elsevier
DOI: 10.1016/j.jhep.2021.11.006

Albumin protects the liver from tumor necrosis factor α-induced immunopathology.

Auteurs: Duran-Güell, M, Flores-Costa, R, Casulleras, M, et al.
Publié dans: The FASEB Journal, 2021, ISSN 1530-6860
Éditeur: Wiley
DOI: 10.1096/fj.202001615rrr

Editorial: Acute-on-chronic liver failure: systemic inflammation and immunosuppression

Auteurs: Olaf Tyc, Yu Shi, Yu-Chen Fan, Jonel Trebicka, Xiaogang Xiang
Publié dans: Frontiers in Immunology, Numéro 14, 2023, ISSN 1664-3224
Éditeur: International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2023.1260749

Management of splanchnic vein thrombosis.

Auteurs: Elkrief L, Payancé A, Plessier A, et al.
Publié dans: JHEP Rep., 2023, ISSN 2589-5559
Éditeur: Elsevier
DOI: 10.1016/j.jhepr.2022.100667

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction-associated fatty liver disease.

Auteurs: López-Vicario C, Sebastián D, Casulleras M, et al.
Publié dans: Hepatology, 2023, ISSN 1527-3350
Éditeur: AALSD
DOI: 10.1002/hep.32647

Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis

Auteurs: Adrià Juanola, Ann Thu Ma, Koos de Wit, Kohilan Gananandan, Olivier Roux, Giacomo Zaccherini, César Jiménez, Marta Tonon, Cristina Solé, Clara Villaseca, Frank E Uschner, Isabel Graupera, Elisa Pose, Maria José Moreta, Daniela Campion, Ulrich Beuers, Rajeshawar P Mookerjee, Claire Francoz, Francois Durand, Victor Vargas, Salvatore Piano, Sonia Alonso, Jonel Trebicka, Wim Laleman, Sumeet K Asr
Publié dans: Gut, Numéro 73, 2024, Page(s) 156-165, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-329923

Controversies regarding albumin therapy in cirrhosis

Auteurs: Jonel Trebicka, Guadalupe Garcia-Tsao
Publié dans: Hepatology, 2024, ISSN 0270-9139
Éditeur: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000521

Mitochondrial Dysfunction in Advanced Liver Disease: Emerging Concepts.

Auteurs: Zhang IW, López-Vicario C, Duran-Güell M, Clària J.
Publié dans: Front Mol Biosci., 2021, ISSN 2296-889X
Éditeur: Frontiers
DOI: 10.3389/fmolb.2021.772174

Recent advances in the prevention and treatment of decompensated cirrhosis and acute-on-chronic liver failure (ACLF) and the role of biomarkers

Auteurs: Jonel Trebicka, Ruben Hernaez, Debbie Lindsay Shawcross, Alexander L Gerbes
Publié dans: Gut, Numéro 73, 2024, Page(s) 1015-1024, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-330584

Editorial: Portal Hypertension in Cirrhosis: From Pathogenesis to Novel Treatments

Auteurs: Herath CB, Angus PW, Trebicka J.
Publié dans: Front Physiol., 2022, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.864083

Acute-On-Chronic Liver Failure: Current Interventional Treatment Options and Future Challenges

Auteurs: Markus Kimmann, Jonel Trebicka
Publié dans: Journal of Personalized Medicine, Numéro 13, 2024, Page(s) 1052, ISSN 2075-4426
Éditeur: MPDI
DOI: 10.3390/jpm13071052

Autophagy-Related Activation of Hepatic Stellate Cells Reduces Cellular miR-29a by Promoting Its Vesicular Secretion.

Auteurs: Yu X, Elfimova N, Müller M, et al.
Publié dans: Cell Mol Gastroenterol Hepatol., 2022, ISSN 2352-345X
Éditeur: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2022.02.013

Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models.

Auteurs: Johannes Chang; Jonathan Meinke; Moritz Geck; Marc Hebest; Nina Böhling; Ramona Dolscheid-Pommerich; Birgit Stoffel-Wagner; Glen Kristiansen; Marcus Overhaus; Leon O. Peyman; Sabine Klein; Frank E. Uschner; Maximilian J. Brol; Tim O. Vilz; Philipp Lingohr; Jörg C. Kalff; Christian Jansen; Christian P. Strassburg; Sven Wehner; Jonel Trebicka; Jonel Trebicka; Michael Praktiknjo
Publié dans: Frontiers in Physiology, Numéro 1, 2021, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.720898

Acute-on-chronic liver failure: a global disease

Auteurs: Schulz M, Trebicka J.
Publié dans: Gut, 2021, ISSN 1468-3288
Éditeur: BMJ
DOI: 10.1136/gutjnl-2020-323973

Monographic books (1)

Guidelines for reviewing health research and innovation that use emergent technologies and personal data

Auteurs: De Lecuona, I
Publié dans: 2020, ISBN 978-84-9168-646-0
Éditeur: Edicions de la Universitat de Barcelona