DECOMPENSATED CIRRHOSIS: IDENTIFICATION OF NEW COMBINATORIAL THERAPIES BASED ON SYSTEMS APPROACHES

Resultado final

ELPA will organize an event aimed at patients and the general public to increase awareness of patients and the general public for cirrhosis and related complications and potential new therapies

Go-online of the public project website

The DECISION website will go live with information on the project on the partners on the disease and it will offer public results for download and references to publications

First patient and layman event

ELPA will organize an event aimed at patients and the general public to increase awareness of patients and the general public for cirrhosis and related complications and potential new therapies

Public engagement strategy to design DECISION along with the need of patients

This document will define the DECISION public engagement strategy in an ethically and legally sound way and build the basis for D72

Codes of conduct applicable and research integrity policy including publications in journals

Definition of the DECISION Code of conduct and research integrity policy for research undertaken in DECISION and publication of results

Checklist for participants to assure informed consent / other mechanisms for those unable to give a written consent

Checklist for informed consent procedures for people unable to give written consent

First written draft of a model describing typical treatment paths in decompensated cirrhosis

Health economic model for treatment paths in decompensated cirrhosis

Project brochure and professional templates

The project flyer will give information on the project and contact details for distribution at conferences A professionally designed poster and PPt template will guarantee growing recognition of the project

Generation of rat models of acute decompensation of cirrhosis developing ACLF

Performing the described models of cirrhosis with the respective triggers of ACLF

Publicaciones

Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction.

Autores: Engelmann C, Clària J, Szabo G, Bosch J, Bernardi M.
Publicado en: J Hepatol., 2021, ISSN 1600-0641
Editor: Elsevier
DOI: 10.1016/j.jhep.2021.01.002

Preoperative TIPS prevents the development of postoperative acute-on-chronic liver failure in patients with high CLIF-C AD score.

Autores: Chang J, Höfer P, Böhling N, et al.
Publicado en: JHEP Rep., 2022, ISSN 2589-5559
Editor: BMJ Journals
DOI: 10.1016/j.jhepr.2022.100442

Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)

Autores: Weiss E, de la Peña-Ramirez C, Aguilar F, et al.
Publicado en: Gut, 2023, ISSN 1468-3288
Editor: BMJ
DOI: 10.1136/gutjnl-2022-328708

Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure.

Autores: Zhang IW, Curto A, López-Vicario C, et al.
Publicado en: J Hepatol., 2022, ISSN 1600-0641
Editor: Elsevier
DOI: 10.1016/j.jhep.2021.08.009

Untargeted lipidomics uncovers lipid signatures that distinguish severe from moderate forms of acutely decompensated cirrhosis

Autores: Clària J, Curto A, Moreau R, et al.
Publicado en: J Hepatol., 2021, ISSN 1600-0641
Editor: Elsevier
DOI: 10.1016/j.jhep.2021.06.043

Trends and the course of liver cirrhosis and its complications in Germany: Nationwide population-based study (2005 to 2018).

Autores: Gu W, Hortlik H, Erasmus HP, et al.
Publicado en: Lancet Reg Health Eur., 2021, ISSN 2666-7762
Editor: Elsevier
DOI: 10.1016/j.lanepe.2021.100240

Baveno VII Faculty. Baveno VII - Renewing consensus in portal hypertension

Autores: de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C;
Publicado en: J Hepatol., 2022, ISSN 1600-0641
Editor: Elsevier
DOI: 10.1016/j.jhep.2021.12.022

Leveraging omics to understand the molecular basis of acute-on-chronic liver failure

Autores: Joan Clària
Publicado en: instname:Universidad de Barcelona, Edición 1, 2021, ISSN 2628-491X
Editor: De Gruyter
DOI: 10.1515/almed-2021-0023

Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease.

Autores: Trebicka J, Gu W, de Ledinghen V, et al.
Publicado en: Gut, 2022, ISSN 1468-3288
Editor: BMJ
DOI: 10.1136/gutjnl-2020-323419

Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study

Autores: Buch S, Innes H, Lutz PL, et al.
Publicado en: Gut, 2023, ISSN 1468-3288
Editor: BMJ Journals
DOI: 10.1136/gutjnl-2022-327196

The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis

Autores: Innes H, Nischalke HD, Guha IN, et al.
Publicado en: Hepatol Commun., 2022, ISSN 2471-254X
Editor: Wolters Kluwer
DOI: 10.1002/hep4.1886

Essential role for albumin in preserving liver cells from TNFα-induced mitochondrial injury

Autores: Duran-Güell M, Garrabou G, Flores-Costa R, et al.
Publicado en: FASEB J, 2023, ISSN 1530-6860
Editor: Wiley
DOI: 10.1096/fj.202201526r

Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators.

Autores: Sánchez-Rodríguez MB, Téllez É, Casulleras M, et al.
Publicado en: Front Immunol., 2022, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2022.842996

Stratifying the risk of NAFLD in patients with HIV under combination antiretroviral therapy (cART).

Autores: Bischoff J, Gu W, Schwarze-Zander C, et al.
Publicado en: EClinicalMedicine., 2021, ISSN 2589-5370
Editor: Elsevier
DOI: 10.1016/j.eclinm.2021.101116

redicting bleeding after liver biopsy using comprehensive clinical and laboratory investigations: A prospective analysis of 302 procedures

Autores: Bissonnette J, Riescher-Tuczkiewicz A, Gigante E, et al.
Publicado en: J Thromb Haemost., 2022, ISSN 1538-7836
Editor: John Wiley
DOI: 10.1111/jth.15888

Restoration of the gut microbiota is associated with a decreased risk of hepatic encephalopathy after TIPS

Autores: Li M, Li K, Tang S, et al.
Publicado en: JHEP Rep., 2022, ISSN 2589-5559
Editor: ELSEVIER
DOI: 10.1016/j.jhepr.2022.100448

Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure

Autores: Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U. Macías-Rodríguez, Astrid Ruiz-Margáin, Robert Schierwagen, Hui Liu, Chen Shao, Chunlei Fan, Rilu Feng, Xiaodong Yuan, Sai Wang, Franziska Wandrer, Christoph Meyer, Ralf Wimmer, Roman Liebe, Jens Kroll, Long Zhang, Tobias Schiergens, Peter ten Dijke, Andreas Teufel, Alexander Marx, Peter R. Mertens, Hua Wang, Matthias P.A. Ebert,
Publicado en: Hepatology, 2022, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.32119

Proresolving lipid mediators and liver disease.

Autores: Clària J, Flores-Costa R, Duran-Güell M, López-Vicario C.
Publicado en: Biochim Biophys Acta Mol Cell Biol Lipids., 2021, ISSN 1879-2618
Editor: Frontiers
DOI: 10.1016/j.bbalip.2021.159023

Early transplantation maximizes survival in severe acute-on-chronic liver failure: Results of a Markov decision process model.

Autores: Zhang S, Suen SC, Gong CL, et al.
Publicado en: JHEP Rep., 2021, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2021.100367

Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis.

Autores: Reiniš J, Petrenko O, Simbrunner B, et al.
Publicado en: J Hepatol., 2023, ISSN 1600-0641
Editor: Elsevier
DOI: 10.1016/j.jhep.2022.09.012

Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis.

Autores: Tantai X, Liu Y, Yeo YH, et al.
Publicado en: J Hepatol., Edición Elsevier, 2022, Página(s) N/A, ISSN 1600-0641
Editor: Elsevier
DOI: 10.1016/j.jhep.2021.11.006

Albumin protects the liver from tumor necrosis factor α-induced immunopathology.

Autores: Duran-Güell, M, Flores-Costa, R, Casulleras, M, et al.
Publicado en: The FASEB Journal, 2021, ISSN 1530-6860
Editor: Wiley
DOI: 10.1096/fj.202001615rrr

Management of splanchnic vein thrombosis.

Autores: Elkrief L, Payancé A, Plessier A, et al.
Publicado en: JHEP Rep., 2023, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2022.100667

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction-associated fatty liver disease.

Autores: López-Vicario C, Sebastián D, Casulleras M, et al.
Publicado en: Hepatology, 2023, ISSN 1527-3350
Editor: AALSD
DOI: 10.1002/hep.32647

Mitochondrial Dysfunction in Advanced Liver Disease: Emerging Concepts.

Autores: Zhang IW, López-Vicario C, Duran-Güell M, Clària J.
Publicado en: Front Mol Biosci., 2021, ISSN 2296-889X
Editor: Frontiers
DOI: 10.3389/fmolb.2021.772174

Editorial: Portal Hypertension in Cirrhosis: From Pathogenesis to Novel Treatments

Autores: Herath CB, Angus PW, Trebicka J.
Publicado en: Front Physiol., 2022, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.864083

Autores: Yu X, Elfimova N, Müller M, et al.
Publicado en: Cell Mol Gastroenterol Hepatol., 2022, ISSN 2352-345X
Editor: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2022.02.013

Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models.

Autores: Johannes Chang; Jonathan Meinke; Moritz Geck; Marc Hebest; Nina Böhling; Ramona Dolscheid-Pommerich; Birgit Stoffel-Wagner; Glen Kristiansen; Marcus Overhaus; Leon O. Peyman; Sabine Klein; Frank E. Uschner; Maximilian J. Brol; Tim O. Vilz; Philipp Lingohr; Jörg C. Kalff; Christian Jansen; Christian P. Strassburg; Sven Wehner; Jonel Trebicka; Jonel Trebicka; Michael Praktiknjo
Publicado en: Frontiers in Physiology, Edición 1, 2021, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.720898

Acute-on-chronic liver failure: a global disease

Autores: Schulz M, Trebicka J.
Publicado en: Gut, 2021, ISSN 1468-3288
Editor: BMJ
DOI: 10.1136/gutjnl-2020-323973

Guidelines for reviewing health research and innovation that use emergent technologies and personal data

Autores: De Lecuona, I
Publicado en: 2020, ISBN 978-84-9168-646-0
Editor: Edicions de la Universitat de Barcelona

Resultado final

Publicaciones

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